Health‐Promoting Properties of <i>Eucommia ulmoides</i>: A Review

Hussain, Tarique; Tan, Bin; Liu, Gang; Oso, A.O.; Rahu, Najma; Tossou, Myrlene Carine B.; Yin, Yulong

doi:10.1155/2016/5202908

Cited by 76 publications

(58 citation statements)

References 64 publications

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“…Eucommia ulmoides (EU) (also known as “Du Zhong” in Chinese) contains enriched chemical components such as lignins, iridoids, phenolics, steroids, and flavonoids and, therefore, presents various medicinal properties as a Chinese traditional medicine [8, 10]. The leaf of EU also contains abundant secondary metabolites, such as flavonoids [8, 11, 12].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Antioxidant and Anti‐Inflammatory Effects of Eucommia ulmoides Flavones Using Diquat‐Challenged Piglet Models

Yuan

Hussain

Tan

et al. 2017

Oxidative Medicine and Cellular Longevity

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This study was designed to evaluate the antioxidant and anti-inflammatory effects of Eucommia ulmoides flavones (EUF) using diquat-challenged piglet models. A total of 96 weaned piglets were randomly allotted to 1 of 3 treatments with 8 replication pens per treatment and 4 piglets per pen. The treatments were basal diet, basal diet + diquat, and 100 mg/kg EUF diet + diquat. On day 7 after the initiation of treatment, the piglets were injected intraperitoneally with diquat at 8 mg/kg BW or the same amount of sterilized saline. The experiment was conducted for 21 days. EUF supplementation improved the growth performance of diquat-treated piglets from day 14 to 21. Diquat also induced oxidative stress and inflammatory responses and then impaired intestinal morphology. But EUF addition alleviated these negative effects induced by diquat that showed decreasing serum concentrations of proinflammatory cytokines but increasing antioxidant indexes and anti-inflammatory cytokines on day 14. Supplementation of EUF also increased villi height and villous height, crypt depth, but decreased the histopathological score and MPO activity compared with those of diquat-challenged pigs fed with the basal diet on day 14. Results indicated that EUF attenuated the inflammation and oxidative stress of piglets caused by diquat injection.

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Section: Introductionmentioning

confidence: 99%

The Evaluation of Antioxidant and Anti‐Inflammatory Effects of Eucommia ulmoides Flavones Using Diquat‐Challenged Piglet Models

Yuan

Hussain

Tan

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…But supplementation with functional bioactive substances increased the serum GSH concentration, SOD and CAT activities. Functional bioactive substance directly inhibited ROS production or protect against antioxidant defenses to inhibit ROS formation (Hussain, Tan, Liu, Oladele, & Yin, 2016). For example, the Table 5.…”

Section: Discussionmentioning

confidence: 99%

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

Wang

Tan

Liao

et al. 2020

Food and Agricultural Immunology

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This study was conducted to investigate the effects of composited functional bioactive substances on the growth performance and immune function of growth retardation (GR) pigs. Twenty-four 42day-old GR pigs were fed with basal diet containing 0 or 0.5% composited functional bioactive substances package (FP) for 21 days. The results showed that dietary supplementation with FP decreased feed:gain ratio, increased the relative and absolute weight of the liver (P < 0.05). Supplementation with FP decreased serum alkaline phosphatase and malondialdehyde, but increased aspartic acid, cysteine, arginine, proline and taurine concentrations, as well as serum superoxide dismutase and catalase activities (p < 0.05). FP treatment increased all determined cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, GM-CSF, IFN-γ, TGF-β1, TNF-α) concentrations in serum compared with the control treatment (p < 0.05). These findings indicate that functional bioactive substances can improve feed conversion rate, serum anti-oxidant capacity and immunity and can be as effective growth promoter in the GR piglets.

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“…The herb Eucommia ulmoides Oliver (Du-Zhong) has been used in various clinical situations (16,17); traditionally, it was used for strengthening muscles and pulmonary function, reducing blood pressure and preventing miscarriages. Numerous active components have been identified from Eucommia ulmoides Oliver, including lignans, polyphenolics, triterpenes and flavonoids (18). Among the active components, the main bioactive components, Eucommia lignans, have protective effects against hypertensive renal injury (19).…”

Section: (+)-Pinoresinol-o-β-d-glucopyranoside From Eucommia Ulmoidesmentioning

confidence: 99%

(+)‑pinoresinol‑O‑β‑D‑glucopyranoside from Eucommia�ulmoides Oliver and its anti‑inflammatory and antiviral effects against influenza�A (H1N1) virus infection

Liang

Zhou

et al. 2018

Mol Med Report

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Eucommia ulmoides Oliver (Du-Zhong) is an ancient Chinese herbal remedy used for the treatment of various diseases. To date, the effects of its constituent lignans on influenza viruses remain to be elucidated. In the present study, a lignan glycoside was isolated and purified from Eucommia ulmoides Oliver. Its structures were identified via extensive spectroscopic analysis, and its antiviral and anti-inflammatory activities, specifically against influenza viruses, were determined via a cytopathic effect (CPE) assay, plaque-reduction assays, a progeny virus yield reduction assay, reverse transcription-quantitative polymerase chain reaction analysis and a Luminex assay. Additionally, western blot analysis was performed to investigate the underlying mechanisms of its effects against influenza viruses. The chemical and spectroscopic methods determined the structure of lignan glycoside to be (+)-pinoresinol-O-β-D-glucopyranoside. The CPE assay showed that (+)-pinoresinol-O-β-D-glucopyrano side exerted inhibitory activities with 50% inhibition concentration values of 408.81±5.24 and 176.24±4.41 µg/ml against the influenza A/PR/8/34 (H1N1) and A/Guangzhou/GIRD07/09 (H1N1) strains, respectively. Its antiviral properties were confirmed by plaque reduction and progeny virus yield reduction assays. Additional mechanistic analyses indicated that the anti-H1N1 virus-induced effects of (+)-pinoresinol-O-β-D-gl ucopyranoside were likely due to inactivation of the nuclear factor-κB, p38 mitogen-activated protein kinase and AKT signaling pathways. Furthermore, (+)-pinoresinol-O-β-D-glu copyranoside exhibited pronounced inhibitory effects on the expression of influenza H1N1 virus-induced pro-inflammatory mediators, including tumor necrosis factor-α, interleukin (IL)-6, IL-8 and monocyte chemoattractant protein 1. The data obtained suggest that (+)-pinoresinol-O-β-D-glucopyra noside may be a candidate drug for treating influenza H1N1 virus infection.

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Health‐Promoting Properties of Eucommia ulmoides: A Review

Cited by 76 publications

References 64 publications

The Evaluation of Antioxidant and Anti‐Inflammatory Effects of Eucommia ulmoides Flavones Using Diquat‐Challenged Piglet Models

The Evaluation of Antioxidant and Anti‐Inflammatory Effects of Eucommia ulmoides Flavones Using Diquat‐Challenged Piglet Models

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

(+)‑pinoresinol‑O‑β‑D‑glucopyranoside from Eucommia�ulmoides Oliver and its anti‑inflammatory and antiviral effects against influenza�A (H1N1) virus infection

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