Health related quality of life in people with advanced chronic liver disease

Orr, James; Homer, Tara; Ternent, Laura; Newton, Julia L.; McNeil, Calum J.; Hudson, Mark; Jones, David

doi:10.1016/j.jhep.2014.06.034

Cited by 123 publications

(111 citation statements)

References 59 publications

(89 reference statements)

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“…Chronic liver disease alters sexual function, thereby reducing quality of life . At the endocrine level, the partial improvement in sexual function after LT observed in the current work may be explained by improvement in the hypothalamic–pituitary–gonadal axis and sex hormone transport.…”

Section: Discussionmentioning

confidence: 56%

Effects of liver transplantation on endocrine function: a systematic review

Gariani

Toso

Philippe

et al. 2016

Liver International

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Patients with chronic liver disease (CLD) often experience secondary endocrine dysfunction. Therefore, because the liver plays a major role in endocrine function, liver transplantation (LT) may also be beneficial for the restoration of hormonal regulation. This systematic review collects and interprets the available literature on the effect of LT on endocrine and sexual function in adult patients. A systematic review was conducted by searching Pubmed (including Medline) and EMBASE for studies published from database inception until November 2015. We collected all relevant studies that discussed changes in hormonal and sexual function after LT. Studies were included if they assessed the effect of LT on sexual function or one of the following components of the hormone/endocrine axis: the hypothalamus-pituitary-gonadal axis, growth hormone (GH), insulin-like growth factor-1 (IGF-1) or thyroid function. The results are reported according to the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. Twenty-one studies with a total of 1274 patients were included. The results collected from the included studies suggested that LT improves the hormonal perturbation associated with CLD by restoring physiological levels of circulating GH, IGF-1, testosterone, estradiol, prolactin, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Thyroid function was not affected by LT, and sexual function was partially improved after LT. This systematic review suggests that LT is associated with an improvement in endocrine and sexual function in patients with CLD. This information should encourage clinicians who treat CLD patients to identify endocrine disturbances in this population, inform their patients of the effects of LT and assess post-transplantation improvements. Keywords endocrine dysfunction -hormone -liver transplantationThe liver plays a key role in a myriad of metabolic processes, including regulation of the endocrine system, which consists of a fine-tuned network of cells, glands and organs that secrete hormones directly into the blood to control physiological and behavioural activities (1, 2). Liver dysfunction often results in endocrine perturbations through the abolition of the balanced crosstalk between the endocrine system and the hepatic microenvironment (1, 3). Patients with advanced liver failure experience various hormonal alterations, which Abbreviations

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Section: Discussionmentioning

confidence: 56%

Effects of liver transplantation on endocrine function: a systematic review

Gariani

Toso

Philippe

et al. 2016

Liver International

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“…Overt hepatic encephalopathy (HE) requiring hospital admission is a common complication of cirrhosis that is associated with high resource utilization and a significant in-hospital mortality [1,2]. HE patients have a significantly lower survival compared with patients without HE at all severities of liver disease [3,4].…”

Section: Introductionmentioning

confidence: 99%

Modification in CSF specific gravity in acutely decompensated cirrhosis and acute on chronic liver failure independent of encephalopathy, evidences for an early blood-CSF barrier dysfunction in cirrhosis

et al. 2016

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“…They can be applied in specific populations with certain pathological conditions, and offer the advantage of a more detailed analysis of the impact and limitations caused by the disease in the lives of individuals, identifying particularities of the situation. The highlights among specific instruments for patients with liver disease are the Chronic Liver Disease Questionnaire (CLDQ), the Liver Disease Symptom Index (LDSI) and the Liver Disease Quality of Life (LDQOL) (5) . During the literature search on studies assessing the quality of life in patients undergoing liver transplant, studies using specific instruments were scarce.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in liver transplant recipients and the influence of sociodemographic factors

Aguiar

Braga

Garcia

et al. 2016

Rev. esc. enferm. USP

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Objective:To verify the influence of sociodemographic factors on the quality of life of patients after liver transplant. Method: Cross-sectional study with 150 patients who underwent liver transplant at a referral center. A sociodemographic instrument and the Liver Disease Quality of Life questionnaire were applied. The analysis of variance (ANOVA) was performed, as well as multiple comparisons by the Tukey test and GamesHowell tests when p <0.05. Results: Old age had influence on domains of symptoms of liver disease (p = 0.049), sleep (p = 0.023) and sexual function (p = 0.03). Men showed better significant mean values than women for the loneliness dimension (p = 0.037). Patients with higher educational level had higher values for the domain of stigma of liver disease (p = 0.014). There was interference of income in the domains of quality of social interaction (p = 0.033) and stigma of the disease (p = 0.046). Conclusion: In half of the quality of life domains, there was influence of some sociodemographic variable. DESCRIPTORS

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Health related quality of life in people with advanced chronic liver disease

Cited by 123 publications

References 59 publications

Effects of liver transplantation on endocrine function: a systematic review

Effects of liver transplantation on endocrine function: a systematic review

Modification in CSF specific gravity in acutely decompensated cirrhosis and acute on chronic liver failure independent of encephalopathy, evidences for an early blood-CSF barrier dysfunction in cirrhosis

Quality of life in liver transplant recipients and the influence of sociodemographic factors

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