Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Abstract

Background Highly Active Antiretroviral Therapy (HAART) is a standard of HIV management to suppress viral load and delay progression to AIDS. However, questions have been raised about the use of antiretroviral therapy and how it affects quality of life (QoL) of people living with HIV/ AIDS (PLWHA). The study hence aimed to assess the QoL of PLWHA who were taking HAART at Mizan-Tepi University Teaching Hospital (MTUTH) and identify factors associated with QoL. Methods A cross sectional study was conducted among PLWHA receiving HAART at MTUTH from March 04-April 1, 2018. Patients were recruited consecutively and interviewed with structured questionnaire. A data abstraction tool was used to extract data from patient medical records. Quality of life was assessed using the World Health Organization Quality of Life HIV-BREF (WHOQOL-HIV-BREF) standard tool. Data was entered to Epi-Info version 3.5.3 and analyzed using SPSS version 22 for windows. A multivariable logistic regression analysis was fitted to identify factors associated with QoL. A statistical significance was established at a p value <0.05. Results A total of 240 participants with the mean age of 35.11 (SD = 9.08) years were included in the study. This study found that 57.1% of the patients had high global score of QoL. Patients with normal current health (AOR = 3.38, 95% CI = 1.56-7.31)) and having family support (AOR = 3.12, 95% CI = 1.51-6.46) were positively associated with high global score of QoL, while patients with low HAART adherence (AOR = 0.40, 95%, CI = 0.19-0.86) were negatively associated with high global score of QoL.

Quality of life of HIV-infected individuals: insights from a study of patients in Kermanshah, Iran

“…HIV is one of the major health problems in the worldwide [ 1 – 8 ]. Most HIV infected people live in developing countries [ 9 ]. Although, governments and health organizations invest a lot to improve the health conditions of PLWH [ 1 , 10 – 12 ], the QOL of PLWH still needs a special attention [ 12 ].…”

The Correlation of Antiretroviral Consumption Adherence on the Quality of Life of HIV Patients: A Systematic Review

“…A study from Desta (2020) revealed that more than half of participants adhering to ARVs were related to having better global scoresfrom life quality (Desta et (Lahai et al, 2020), (Primeira et al, 2020), (Xiao et al, 2019), (Nyongesa et al, 2018), (Reis et al, 2020), (Sabino et al, 2020). Quality of life globally (Reis et al, 2020), (Xiao et al, 2019), (Desta et al, 2020), (Bulali et al, 2018) Sexual function / sex (Sabino et al, 2020), (Primeira et al, 2020) Virus suppression (Kagee et al, 2016), (Tran et al, 2018) Viral load was decreased, CD 4, lymphocytewere increased, disease progression was decreased, the opportunistic infection was decreased, body immune was increased. (Kagee et al, 2016), (Primeira et al, 2020), (Xiao et al, 2019), (Reis et al, 2020).…”

“…A total of 15 articles selected in the line review published between 2016 and 2020 are international journals originating from the country (Brazil = 2); (Betancur et al, 2017), (Sabino et al, 2021), (Africa = 3); (Nyongesa et al, 2018), (Bulali et al, 2018), (Kagee et al, 2016), (China = 2); (Xiao et al, 2019), (Tran et al, 2018), (Indonesian = 2) (Suryana et al, 2019), (Khotimah et al, 2018), (Eutopia = 2) (Asrat et al, 2020), (Desta et al, 2020), (Indian = 1) (Sarkar et al, 2019), (USA = 3), (Lahai et al, 2020), (Reis et al, 2019), (Primeira et al, 2020). The total number of respondents in this review were 5,416 respondents, with a total population involved between 83 and 1395 participants.…”

“…A systematic review of this review was all studies that had been synthesized and then grouped into 3 groups, based on: The correlation adherence of antiretroviral (ARVs) drugs consumption to the enhancement of the quality of life of HIV AIDS patients (Desta et al, 2020), (Xiao et al, 2019), (Reis et al, 2019), (Nyongesa et al, 2018), (Lahai et al, 2020), (Sabino et al, 2021), (Primeira et al, 2020), (Kagee et al, 2016), (Tran et al, 2018). Factors affecting the adherence to antiretroviral (ARV) therapy in HIV patients (Asrat et al, 2020), (Reis et al, 2019), (Nyongesa et al, 2018), (Betancur et al, 2017), (Lahai et al, 2020), (Suryana et al, 2019), (Desta et al, 2020), (Bulali et al, 2018), (Sabino et al, 2021), (Mohebi et al, 2018), (Kagee et al, 2016), (Khotimah et al, 2018), (Tran et al, 2018) and other factors that influenced Quality of Life (QoL) besides ARV in HIV patients (Asrat et al, 2020), (Nyongesa et al, 2018), (Xiao et al, 2019), (Betancur et al, 2017), (Lahai et al, 2020), (Desta et al, 2020), (Sabino et al, 2021), (Primeira et al, 2020), (Mohebi et al, 2018), (Kagee et al, 2016).…”

“…The recommended combination of antiretroviral drugs is capable to aggressively suppress the development of the virus in the body. Therefore, it results in preventing HIV progression to AIDS to enhance the improvement of patient survival and quality of life (Desta et al, 2020). One of the formidable challenges faced by HIV patients is the impaired quality of life due to the negative impact on their physical and mental health (Xiao et al, 2019).…”