Health-related quality of life after adjuvant and salvage postoperative radiotherapy for prostate cancer – A prospective analysis

Treatment-related toxicity and symptom-related bother followingpostoperative radiotherapy for prostate cancer

“…Extreme unhappiness was reported by 42.7%, and is consistent with the finding that 55.6 % maintained a moderate to very high the level of sexual interest, but 88.3% experienced impaired function. This level of impairment is similar to that reported by Moinpour and colleagues 28 and Pinkawa and colleagues 30 following combined therapy, which was 80% and 93%, respectively. The pre-radiotherapy impairment rate of 79.5% in this series is consistent with other reports of sexual dysfunction following surgery alone, although nerve-sparing surgery was not routine in our patients.…”

“…13,29,30 Hu and colleagues demonstrated a greater decrement in bowel and bladder functioning 12 to 18 months after combined therapy compared to surgery alone. 13 Pearse and colleagues 29 and Pinkawa and colleagues 30 only investigated the effects of combined treatment, and concluded that the long-term effects on quality of life were small after the acute radiation period had passed.…”

Image-guided radiotherapy for prostate cancer

“…A satisfactory bladder filling additionally reduces treatment-related toxicity in definitive or postoperative radiotherapy for prostate cancer [17][18][19]. No negative effects result concerning the target motion variability in comparison to a treatment with an empty bladder [15].…”

Salvage versus adjuvant radiotherapy after radical prostatectomy: argument for adjuvant radiotherapy

“…Health-related quality of life was compared prospectively by Pinkawa and colleagues 23 after ART and SRT in 101 patients. The authors noted that mild bowel symptoms did require longer to recover than urinary symptoms, although 1 year after radiotherapy there were only minor health-related quality of life changes.…”