Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study

Verveen, Anouk; Wynberg, Elke; Willigen, Hugo D.G. van; Davidovich, Udi; Lok, Anja; Charante, Eric P. Moll van; Jong, Menno D. de; Bree, Godelieve de; Prins, Maria; Knoop, Hans; Nieuwkerk, Pythia T.; Agard, Ivette; Ayal, Jane; Cavdar, Floor; Craanen, Marianne; Deuring, Annemarieke; Dijk, Annelies van; Ersan, Ertan; Grande, Laura del; Hartman, Joost; Koedoot, Nelleke; Leenstra, Tjalling; Lebbink, Romy; Loomans, Dominique; Makowska, Agata; Maine, Tom du; Man, Ilja de; Matser, Amy; Meij, Lizenka van der; Polanen, Marleen van; Oud, Maria; Reid, Clark; Storey, Leeann; Wijk, Marc van; Aardweg, Joost van den; Assem, Joyce van; Beek, Marijne van; Blankert, Thyra; Dijkstra, Maartje; Figaroa, Orlane J.A.; Frenkel, Leah; Gils, Marit J. van; Haga, Jelle van; Han, Xiaochuan Alvin; Harskamp-Holwerda, Agnes; Hazenberg, Mette D.; Hidad, Soemeja; Jong, Nina de; Kootstra, Neeltje A.; Kuijt, Lara; Russell, Colin A.; Straten, Karlijn van der; Veen, Annelou van der; Verkaik, Bas; Visser, Gerben-Rienk

doi:10.1186/s12916-022-02615-7

Cited by 21 publications

(20 citation statements)

References 27 publications

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“…43 Patients with more comorbidities (including hypertension, diabetes, chronic lung disease) and higher BMI had a poorer QOL post-infection, in particular, lower PCS scores. 42,44,45 Similar to the present study, previous studies showed that patients with impaired DLCO had a worse QOL regardless of the disease severity. 24,46 Hence, patients with these risk factors should be identi ed early and followed up closely.…”

Section: Impact Of Covid-19 On Qolsupporting

confidence: 89%

Post-COVID-19 long term impact on lung function and quality of life: who should be concerned?

Toh

Teo

Poh

et al. 2023

Preprint

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Post-COVID-19 pulmonary sequalae are well-recognized early in the pandemic. Survivorship clinics are crucial for managing at-risk patients. However, it is unclear who requires pulmonary function test (PFT) and when PFTs should be performed. We aim to investigate for whom and how these interval PFTs should be performed. We performed a single-centre, prospective cohort study on COVID-19 survivors between 1st May 2020 to 31st April 2022. These patients were followed up at 6, 9 and 12 months with interval PFT and Short Form-36 (SF-36) Health Survey. Those with PFT defects were offered a computed tomography scan of the thorax. Of the 46 patients recruited, 17 (37%) had severe/critical illness. Compared to those with mild/moderate disease, these patients were more likely to experience DLCO defects (59% versus 17%, p = 0.005) and had lower SF-36 scores (mean physical component summary score of 45 ± 12 versus 52 ± 8, p = 0.046). These differences were most notable at 6 months, compared to the 9- and 12-months intervals. DLCO defects were also associated with older age, raised inflammatory markers and extensive CXR infiltrates. Besides interstitial-like abnormalities, obesity and undiagnosed lung conditions accounted for 39% of the PFT abnormalities. Interval PFTs can be performed earliest 6 months post-COVID-19. Patients with normal tests were unlikely to develop new abnormalities and would not require repeat PFTs. Abnormal PFTs can be followed-up with repeat PFTs 6 monthly until resolution. Non-COVID-19 differentials should be considered for persistent PFT abnormalities.

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Section: Impact Of Covid-19 On Qolsupporting

confidence: 89%

Post-COVID-19 long term impact on lung function and quality of life: who should be concerned?

Toh

Teo

Poh

et al. 2023

Preprint

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“…Like the observed pattern in the Psychological‐WHOQoL‐BREF dimension, the differences identified in this study were unexpected, as those with a less severe manifestation of COVID‐19 exhibited lower EQ‐5D scores. These differences went in the opposite direction of what had been seen in previous studies 27,31 . Because participants in the M‐PCC group had been experiencing symptoms longer than the participants in the other groups, they may have perceived their HRQoL to be poorer.…”

Section: Discussionmentioning

confidence: 56%

“…On the other hand, further studies reported that, 3 months post‐recovery, no differences were found between ICU, moderate, and mild groups 29 or between ICU and non‐ICU groups 30 . In the long term, 12 months post‐infection, people with mild COVID‐19 had QoL scores within population norms, whereas those with moderate or severe/critical disease had scores below 31 …”

Section: Introductionmentioning

confidence: 95%

“…30 In the long term, 12 months post-infection, people with mild COVID-19 had QoL scores within population norms, whereas those with moderate or severe/critical disease had scores below. 31 Synthesizing previous research can be challenging due to the diversity of cohorts or the variation in time between disease onset and HRQoL assessment. Furthermore, most studies have compared HRQoL scales with population norms.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive and emotional predictors of quality of life and functioning after COVID‐19

Ariza,

Cano,

Segura

et al. 2023

Ann Clin Transl Neurol

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ObjectiveA long‐term decline in health‐related quality of life (HRQoL) has been reported after coronavirus disease 2019 (COVID‐19). Studies with people with persistent symptoms showed inconsistent outcomes. Cognition and emotion are important determinants in HRQoL, but few studies have examined their prognostic significance for HRQoL and functionality in post‐COVID patients with persisting symptoms. We aimed to describe QoL, HRQoL, and functioning in individuals post‐COVID with varying COVID‐19 severities and to investigate the predictive value of cognitive and emotional variables for QoL, HRQoL, and functioning.MethodsIn total, 492 participants (398 post‐COVID and 124 healthy controls) underwent a neurobehavioral examination that included assessments of cognition, mood, QoL/HRQoL (WHOQOL‐BREF, EQ‐5D), and functioning (WHODAS‐II). Analysis of covariance and linear regression models were used to study intergroup differences and the relationship between cognitive and emotional variables and QoL and functioning.ResultsThe Physical and Psychological dimensions of WHOQoL, EQ‐5D, and WHODAS Cognition, Mobility, Life Activities, and Participation dimensions were significantly lower in post‐COVID groups compared with a control group. Regression models explaining 23.9%–53.9% of variance were obtained for the WHOQoL‐BREF dimensions and EQ‐5D, with depressive symptoms, post‐COVID symptoms, employment status, income, and mental speed processing as main predictors. For the WHODAS, models explaining 17%–60.2% of the variance were obtained. Fatigue, depressive symptoms, mental speed processing, and post‐COVID symptoms were the main predictors.InterpretationQoL/HRQoL and functioning after COVID‐19 in individuals with persistent symptoms were lower than in non‐affected persons. Depressive symptoms, fatigue, and slower mental processing speed were predictors of lower QoL/HRQoL and functioning.

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“…Neither of these two hypotheses were supported by the results of the study. Trying to give an explanation of this, it could be that respondents who declared that they had contracted the infection (or who reported such a circumstance for a family member or acquaintances) could mainly have experienced a not severe/mild form of the virus or experienced a (direct or closely indirect) contagion quite a long time before the survey, in line with some research on the topic [74].…”

Section: Discussionmentioning

confidence: 85%

Motivations, Relationships, Health and Quality of Life of Older Volunteers in Times of COVID-19 Pandemic

et al. 2023

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Within the active ageing framework, this study was carried out during the COVID-19 pandemic on older volunteers, in order to explore the possible relation between, on the one hand, changes in their health, social relationships and quality of life due to the pandemic and, on the other hand, volunteers’ motivations and (direct or indirect) experience of the COVID-19 contagion. Although various active-ageing-related issues have been studied during the pandemic, the studies did not cover the topic of the present study. Therefore, the results of this study advance the knowledge on the matter. A sample of 240 older volunteers was surveyed in Italy in July–August 2021. Bivariate analyses and multivariable logistic regression models were performed. The results highlighted that during the COVID-19 pandemic, for older people, volunteering in order to avoid thinking about personal problems was related to worsened health, while volunteering for social reasons was inversely related to a worsening quality of life. Having indirectly (by acquaintances) experienced the COVID-19 contagion was protective against the worsening physical health of older volunteers. The discussion includes the policy implications of the results.

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Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study

Cited by 21 publications

References 27 publications

Post-COVID-19 long term impact on lung function and quality of life: who should be concerned?

Post-COVID-19 long term impact on lung function and quality of life: who should be concerned?

Cognitive and emotional predictors of quality of life and functioning after COVID‐19

Motivations, Relationships, Health and Quality of Life of Older Volunteers in Times of COVID-19 Pandemic

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