Health-Related Quality of Life among Egyptian Female Breast Cancer Patients at the National Cancer Institute, Cairo University

Khater, Amira; Noaman, Maissa K; Hafiz, Marwa N Abdel; Moneer, Manar M.; Elattar, Inas

doi:10.31557/apjcp.2019.20.10.3113

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Age had no significant association with EORTC QLQ-C30 symptom scales. On contrary to our study, age had a significant association with Functional Assessment of Cancer Therapy-Breast questionnaire (FACT B-4) breast cancer QoL assessment tool [37]. This discrepancy between studies might be due to the variation in socioeconomic status, and different QoL assessment tools.…”

Section: Factors Associated To Qol Of Breast Cancer Patientscontrasting

confidence: 99%

“…In the present study, patients who had comorbidity had also more insomnia ( p = 0.029), appetite loss ( p = 0.014), and diarrhoea ( p = 0.007). A study conducted in Cairo had showed patients who had no comorbidities had significantly higher social wellbeing ( p = 0.014) and FWB ( p = 0.004) scores than those who had comorbidities [ 37 ]. Similarly in our study, patients who had no comorbidity had better physical function ( p < 0.001), cognitive function ( p = 0.013), and social function ( p = 0.009).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly in our study, patients who had no comorbidity had better physical function ( p < 0.001), cognitive function ( p = 0.013), and social function ( p = 0.009). A previous study conducted in America on the impact of comorbidity on QoL of cancer patients concluded that comorbidity exerts negative impacts on QoL of breast cancer patients [ 37 – 39 ]. This indicates that integrating information about comorbidity status to breast cancer care would improve the overall QoL outcomes of the patients by providing additional support and care for comorbidity.…”

Section: Discussionmentioning

confidence: 99%

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Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

et al. 2022

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Background Quality of life (QoL) has become an important measure for evaluating cancer patients’ treatment and prognosis. Breast cancer patients are at an increased risk of experiencing poor QoL during active treatment of cancer. This study aimed to assess QoL and it’s influencing factors among breast cancer patients using the newly updated breast cancer specific tool of the European Organisation for Research and Treatment of Cancer EORTC Breast Cancer Specific Quality of Life Questionnaire QLQ-BR45. Methods An institutional based crossectional study was conducted with 248 breast cancer patients at Tikur Anbessa Specialized Hospital (TASH). Descriptive statistics, one-way analysis of variance (ANOVA), and linear regression were used to describe and analyze the data. Results The participant’s Global health status/QoL mean score was 65.6. Among the functional scales, future perspective scored the lowest (57.1, SD ± 37.3). The highest mean score on the symptom scales/items were financial difficulties (50, SD ± 38.6), followed by appetite loss (37.4, SD ± 36.4) and fatigue (34.3, SD ± 27.1) while the lowest symptom score was diarrhoea (6.4 ± 18.4). EORTC QLQ-BR45, future perspective (mean = 57.1, SD ± 37.3) and upset by hair loss (41.8, SD ± 34.6) were the most affected functioning and symptoms scales respectively. An increased stage of tumor was associated with more pain (P = 0.041), appetite loss (P = 0.042), and arm symptoms (P = 0.003). Patients who had no comorbidity had better physical (P < 0.001), cognitive (P = 0.013), and social (P = 0.009) function. Conclusion These specific functional scales and symptoms should be assessed individually to address unmet needs. Clinicians could design psychosocial interventions to improve these function and to reduce symptoms.

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Section: Factors Associated To Qol Of Breast Cancer Patientscontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

et al. 2022

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“…The health-related QoL of 200 Egyptian female breast cancer patients is measured using the functional assessment of cancer therapy-breast for patients with lymphedema in the medical oncology outpatient clinic between December 2015 and March 2018 [22]. The median assessment score is 81 (range 35-133).…”

Section: Discussionmentioning

confidence: 99%

Quality of Life of Bulgarian Breast Cancer Female Patients

Yaneva

Dimitrova

Ivanov

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: During recent years, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in females worldwide and in Bulgaria as well. The issues of satisfactory individual quality of life (QoL) after treatment represent undoubted interest and contribute to the elaboration and implementation of specific assessment questionnaires and scales. AIM: The objective of the present study was to assess some aspects of the QoL in female patients with breast cancer following successful disease management. MATERIALS AND METHODS: We examined a total of 57 female breast cancer patients operated on between 2018 and 2020 at a mean age of 47.89 ± 6.71 years (range, 30–59 years). They filled in the upper limb lymphoedema QoL questionnaire containing 27 items. RESULTS: There was a significant prevalence of the ductal carcinoma and nonspecific invasive carcinoma, of the luminal B- human epidermal growth factor receptor-2 (HER2) positive and luminal B-HER2 negative breast cancer as well as of grade two of differentiation. The responses with “not at all” dominated concerning the domains of “activities of daily living” and “health-related complaints. There was a great variety of the frequency of different patient’s responses to one and the same question when all 27 questions of all 57 patients were assessed as a whole. There was only one response with suffering “a lot” given to all the four items dealing with health-related complaints. The response with “a little” inclination dominated concerning the psychological dimension. The responses with “a lot” disturbance in terms of three items (“in your emotional life with your partner”, “look at yourself in a mirror” and “in your professional relationships”) considerably prevailed indicating the pronounced unfavourable influence on these patients’ quality of social life exerted by the breast cancer. CONCLUSION: Breast cancer moderately affects individual patient’s QoL following successful treatment. Future research using additional specific questionnaires and focusing on the emotional and social aspects of the QoL could contribute to the improvement of patient’s life characteristics.

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“…3 Also, in comparison to younger age groups, the older age group had a significantly higher score on the BC subscale. 4 When compared to the United States (14.7 per 100,000), Egyptian breast cancer patients had a higher mortality rate (20.1 per 100,000). 5 Immunology of BC suggests a dual role of immune cells, including tumour-suppressive or immunosuppressive effect, according to the carcinogenic environment signals.…”

Section: Introductionmentioning

confidence: 98%

Prognostic significance of FOXP3+ tumour-infiltrating Tregs in Egyptian breast cancer patients

et al. 2023

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Objective: To evaluate the prognostic importance of tumour-infiltrating forkhead box P3 protein + regulatory T cells in breast cancer patients.Methods: The case-control study was conducted from January 2020 to March 2021 at the Kafrelsheikh University Hospital, Egypt, and comprised individuals with newly-diagnosed breast cancer who underwent conventional surgery,and controls who had a fibrocystic change of the breast. The density of tumour-infiltrating forkhead box P3 protein + regulatory T cells was assessed by immunohistochemistry. Overall survival and disease free-survival were assessed.Data was analysed using SPSS 25.Results: Of the 100 patients having mean age 44.9±9.1 years, 76(76%) had moderate/strong forkhead box P3 protein expression in tumour-infiltrating regulatory T cells, and 24(24%) with no/low expression. On follow-up, Patients with moderate/strong expression had a significantly greater rate of recurrence (p<0.05). Disease-free survival was substantially shorter in patients with moderate/strong expression compared to those with little or low expression (p=0.035). Compared to individuals with no/low expression, patients with moderate/strong expression had a greater rate of mortality, but the difference was not statistically significant (p>0.05).Conclusions: High density of forkhead box P3 protein + regulatory T cells in Egyptian women with breast cancer may serve as a prognostic indicator.Keywords: T-Lymphocytes, Prognosis, Immunohistochemistry, Breast neoplasms, X chromosome.

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Health-Related Quality of Life among Egyptian Female Breast Cancer Patients at the National Cancer Institute, Cairo University

Abstract: Population-Based Cancer Registry Program in Egypt (2008-2011); BC is the most common cancer in females representing about 32% of all female malignancies with the crude and age-standardized incidence rates of 35.8 and 48.8 per 100,000 population, respectively (Ibrahim et al., 2014).

Cited by 7 publications

References 21 publications

Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

Quality of Life of Bulgarian Breast Cancer Female Patients

Prognostic significance of FOXP3+ tumour-infiltrating Tregs in Egyptian breast cancer patients

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