Health-related quality of life and exercise-based cardiac rehabilitation in contemporary acute coronary syndrome patients: a systematic review and meta-analysis

Candelaria, Dion; Randall, Sue; Ladak, Laila Akbar; Gallagher, Robyn

doi:10.1007/s11136-019-02338-y

Cited by 73 publications

(58 citation statements)

References 60 publications

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“…There is plenty evidence that exercise is an essential therapeutic tool to improve cardiovascular health through enhancing mitochondrial biogenesis and function, restoring and improving vasculature (cardiac remodelling, angiogenesis, blood volume expansion), and the release of myokines from skeletal muscle that preserve or augment cardiovascular function [ 111 ]. It is well-known that structured rehabilitation programs after cardiac disease lead to improvements in mortality, hospital readmission, cardiopulmonary fitness and functional status [ 112 , 113 , 114 ]. Likewise, regular, supervised aerobic exercise training is known to be an excellent nonpharmacological treatment of hypertension [ 115 , 116 ].…”

Section: The Potential Role Of Exercise In Post-covid-19 Syndromementioning

confidence: 99%

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Jimeno-Almazán

Pallarés

Buendía-Romero

et al. 2021

IJERPH

263

163

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The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 syndrome is one of those challenges, having become increasingly common as the pandemic evolves. The latest estimates suggest that 10 to 20% of the SARS-CoV-2 patients who undergo an acute symptomatic phase are experiencing effects of the disease beyond 12 weeks after diagnosis. Although research is beginning to examine this new condition, there are still serious concerns about the diagnostic identification, which limits the best therapeutic approach. Exercise programs and physical activity levels are well-known modulators of the clinical manifestations and prognosis in many chronic diseases. This narrative review summarizes the up-to-date evidence on post-COVID-19 syndrome to contribute to a better knowledge of the disease and explains how regular exercise may improve many of these symptoms and could reduce the long-term effects of COVID-19.

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Section: The Potential Role Of Exercise In Post-covid-19 Syndromementioning

confidence: 99%

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Jimeno-Almazán

Pallarés

Buendía-Romero

et al. 2021

IJERPH

263

163

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“…Due to wider inclusion criteria in terms of time-points for outcome reporting, this is >14 studies identified (8 meta-analysed) in another recent review. 20 Also, our search date was more recent, and we included studies testing exercise-based CR interventions in all manifestations of CAD rather than just those with acute coronary syndrome±revascularisation, angina or angiographically documented CAD. We did, however, exclude one study 53 from our meta-analyses that was included by the previous authors.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…A 2019 systematic review (14 RCTs, N=1739) of CR for people following acute coronary syndrome, published when this paper was being prepared for submission, included eight studies in a meta-analysis and concluded that there were clinically important positive effects on two 36-Item Short Form Survey Instrument (SF-36) domains at 6 months (role physical and general health) and one domain at 12 months (physical function). 20 The objective of this systematic review and metaanalysis was to determine the effect of exercise-based CR on health-related QoL in all people with CAD, in the era of modern medical management.…”

Section: Introductionmentioning

confidence: 99%

Does contemporary exercise-based cardiac rehabilitation improve quality of life for people with coronary artery disease? A systematic review and meta-analysis

et al. 2020

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ObjectivesTo determine the effect of contemporary exercise-based cardiac rehabilitation on generic and disease-specific health related quality of life for people with coronary artery disease.DesignSystematic review and meta-analysis.Study eligibility criteriaRandomised controlled trials testing exercise-based cardiac rehabilitation versus no exercise control that recruited after 31 December 1999. On 30 July 2019, we searched the Cochrane Central Register of Controlled Trials, MEDLINE (Ovid), Embase (Ovid) and CINAHL (EBSCO) databases.Study appraisal and synthesisStudies were screened for inclusion by two independent reviewers. Risk of bias was assessed using the Cochrane risk of bias tool. Data were reported as pooled means (95% CI for between-group difference.ResultsWe identified 24 studies (n=4890). We performed meta-analyses for 15 short-term and 9 medium-term outcomes (36-Item Short Form Survey Instrument (SF-36), EuroQol-5D (EQ-5D) and MacNew, a cardiac-specific outcome). Six short-term and five medium-term SF-36 domains statistically favoured exercise-based cardiac rehabilitation. Only for two short-term SF-36 outcomes, ‘physical function’ (mean difference 12.0, 95% CI 4.4 to 19.6) and ‘role physical’ (mean difference 16.9, 95% CI 2.4 to 31.3), did the benefit appear to be clinically important. Meta-analyses of the short-term SF-36 physical and mental component scores, EQ-5D and MacNew and the medium-term SF-36 physical component score, did not show statistically significant benefits. Only two studies had a low risk of bias (n=463 participants).Conclusions and implications of key findingsThere is some evidence of a short-term benefit of contemporary exercise-based cardiac rehabilitation on quality of life for people with coronary artery disease. However, the contemporary data presented in this review are insufficient to support its routine use.

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“…[1] Through this multimodal approach, an improved clinical prognosis, high quality of life and social participation should be achieved. [1] While the positive effect of CR on the clinical course and health-related quality of life (HRQL) has been sufficiently proven, [2][3][4][5][6] the evidence regarding the impact on occupational outcomes and return to work rates remains inconclusive. [7] However, CR programmes based on a multi-modal approach seem to be at an advantage over exercise-based programmes in terms of both clinical and occupational outcomes.…”

Section: Introductionmentioning

confidence: 99%

Patient-reported outcomes predict return to work and health-related quality of life six months after cardiac rehabilitation: Results from a German multi-centre registry (OutCaRe)

Salzwedel

Koran²,

Langheim

et al. 2020

PLoS ONE

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Background Multi-component cardiac rehabilitation (CR) is performed to achieve an improved prognosis, superior health-related quality of life (HRQL) and occupational resumption through the management of cardiovascular risk factors, as well as improvement of physical performance and patients' subjective health. Out of a multitude of variables gathered at CR admission and discharge, we aimed to identify predictors of returning to work (RTW) and HRQL 6 months after CR. Design Prospective observational multi-centre study, enrolment in CR between 05/2017 and 05/ 2018. Method Besides general data (e.g. age, sex, diagnoses), parameters of risk factor management (e.g. smoking, hypertension), physical performance (e.g. maximum exercise capacity, endurance training load, 6-min walking distance) and patient-reported outcome measures (e.g. depression, anxiety, HRQL, subjective well-being, somatic and mental health, pain, lifestyle change motivation, general self-efficacy, pension desire and self-assessment of the occupational prognosis using several questionnaires) were documented at CR admission

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Health-related quality of life and exercise-based cardiac rehabilitation in contemporary acute coronary syndrome patients: a systematic review and meta-analysis

Cited by 73 publications

References 60 publications

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Does contemporary exercise-based cardiac rehabilitation improve quality of life for people with coronary artery disease? A systematic review and meta-analysis

Patient-reported outcomes predict return to work and health-related quality of life six months after cardiac rehabilitation: Results from a German multi-centre registry (OutCaRe)

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