Health-related quality of life and survival in the 2years after surgery for gastric cancer

Avery, Kerry; Hughes, Rachael A.; McNair, Angus G K; Alderson, Derek; Barham, Paul; Blazeby, Jane M

doi:10.1016/j.ejso.2009.09.008

Cited by 63 publications

(60 citation statements)

References 18 publications

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“…In agreement with these previous studies, our results show that more than half of the patients experienced at least 10% of BWL after gastric cancer resection. In line with our results, previous studies have found a high prevalence of diarrhoea after gastric cancer resection ranging from 20% to 30% (6,7,10,11). In the present study, severe diarrhoea was more common in the group of patients with >10% BWL (13% versus 0%).…”

Section: Discussionsupporting

confidence: 82%

“…A number of studies have described the great impact of gastric resection on HRQL in patients with curable gastric cancer (6,10). It has been shown that HRQL is influenced by the extent of resection (total vs. subtotal or proximal gastrectomy) (4,6) and there is a significant impairment of several aspects of HRQL reported by patients in the immediate postoperative period (6).…”

Section: Discussionmentioning

confidence: 99%

“…Gavazzi et al(5) analysed the nutritional status at the beginning of gastric cancer treatment and reported a body weight loss (BWL) ≥ 10% of usual weight in 17% of patients, having a negative influence on health-related quality of life (HRQL). Several studies have defined HRQL as an important additional outcome measure in gastric cancer patients undergoing resection, showing differences between surgical techniques (6)(7)(8) as well as providing prognostic information (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Weight loss and quality of life in patients surviving 2 years after gastric cancer resection

Climent

Munarriz

Blazeby

et al. 2017

European Journal of Surgical Oncology (EJSO)

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Weight loss and quality of life in patients surviving 2 years after gastric cancer resection

Climent

Munarriz

Blazeby

et al. 2017

European Journal of Surgical Oncology (EJSO)

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“…Information regarding the patient's quality of life after medical interventions could be used to devise a comprehensive consent form that should be given to patients before surgery [69]. Current guidelines in the United Kingdom state that the patient should be informed of what they will or may face as a result of treatment when they give their consent, including any possible changes in their lifestyle [64]. Consequently, the expected quality of life after the applied treatment should always be taken into consideration during the planning of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…These parameters are important for the prevention of deterioration in the quality of life after total or partial gastrectomy. Avery et al [64] conducted a study including 58 patients with gastric cancer who underwent gastrectomy, estimating their quality of life after gastrectomy using the EORTC QLQ-C30. Thirty patients survived for two or more years after surgery (group 1), while 28 patients died within two years of surgery (group 2).…”

Section: Gastrectomymentioning

confidence: 99%

Quality of life after liver transplantation or surgery for cancers of the digestive system

et al. 2014

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Health is defined not only as the absence of disease, but as a state of complete physical, mental and social well-being. Consequently, the evaluation of the quality of life should include these parameters. With the increase in survival rates of patients subjected to liver transplantation for end-stage liver disease or surgical resections for malignancies of the digestive system, much of the attention of health systems has focused on the quality of life of these patients after appropriate treatment. Several studies have assessed the physical, mental and social well-being of patients undergoing surgical treatment. In this review, we summarize what is known so far of the quality of life after liver transplantation, pancreatectomy, oesophagectomy, colectomy, hepatectomy or gastrectomy.

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Laparoscopic versus open subtotal gastrectomy for gastric adenocarcinoma: cost-effectiveness analysis

et al. 2020

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Background: Laparoscopic subtotal gastrectomy (LSG) for cancer is associated with good perioperative outcomes and superior quality of life compared with the open approach, albeit at higher cost. An economic evaluation was conducted to compare the two approaches. Methods: A cost-effectiveness analysis between LSG and open subtotal gastrectomy (OSG) for gastric cancer was performed using a decision-tree cohort model with a healthcare system perspective and a 12-month time horizon. Model inputs were informed by a meta-analysis of relevant literature, with costs represented in 2016 Canadian dollars (CAD) and outcomes measured in quality-adjusted life-years (QALYs). A secondary analysis was conducted using inputs extracted solely from European and North American studies. Deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed. Results: In the base-case model, costs of LSG were $935 (€565) greater than those of OSG, with an incremental gain of 0⋅050 QALYs, resulting in an incremental cost-effectiveness ratio of $18 846 (€11 398) per additional QALY gained from LSG. In the DSA, results were most sensitive to changes in postoperative utility, operating theatre and equipment costs, as well as duration of surgery and hospital stay. PSA showed that the likelihood of LSG being cost-effective at willingness-to-pay thresholds of $50 000 (€30 240) per QALY and $100 000 (€60 480) per QALY was 64 and 68 per cent respectively. Secondary analysis using European and North American clinical inputs resulted in LSG being dominant (cheaper and more effective) over OSG, largely due to reduced length of stay after LSG. Conclusion: In this decision analysis model, LSG was cost-effective compared with OSG for gastric cancer.

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Health-related quality of life and survival in the 2years after surgery for gastric cancer

Cited by 63 publications

References 18 publications

Weight loss and quality of life in patients surviving 2 years after gastric cancer resection

Weight loss and quality of life in patients surviving 2 years after gastric cancer resection

Quality of life after liver transplantation or surgery for cancers of the digestive system

Laparoscopic versus open subtotal gastrectomy for gastric adenocarcinoma: cost-effectiveness analysis

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