Health-related quality of life and depression in an Italian sample of multiple sclerosis patients

Patti, Francesco; Cacopardo, Manuela; Palermo, Filippo; Ciancio, Maria Rita; Lopes, Rossella; Restivo, Domenico A.; Reggio, A.

doi:10.1016/s0022-510x(03)00040-6

Cited by 107 publications

(109 citation statements)

References 31 publications

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“…Earlier findings that cognitive impairments have a major impact on all aspects of QoL [24,25] were confirmed in our study. The same holds true for the impact of depression on QoL [4,5,8,9]. The high prevalence of impairments in excretion and reproductive functions found in earlier studies [27] was confirmed in this study.…”

Section: The Impact Of Disabilities On Qol In People With Ms 977supporting

confidence: 87%

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The impact of disabilities on quality of life in people with multiple sclerosis

et al. 2008

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. (2008). The impact of disabilities on quality of life in people with multiple sclerosis. Multiple Sclerosis, 14(7), 972-980. https://doi.org/10.1177/1352458508091260 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Results Disabilities contributed to a unique and substantial extent to QOL variance. "Impairments in mental functions" was the most important QOL predictor. "Fatigue" showed the highest prevalence and severity scores, while the impact on QOL was limited. The estimated impact on QOL appeared to be dependent on the applied QOL measure: the WHOQOL-BREF was sensitive to disabilities related to all four ICF components, while the SF-36 was only sensitive to disabilities belonging to the 'body functions' and 'activities' components. Conclusion Treatment programmes should target impairments in cognitive functioning, emotional functioning and sleep. Interventions are best evaluated using the WHOQOL-BREF. Multiple Sclerosis 2008; 14: 972-980.

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Section: The Impact Of Disabilities On Qol In People With Ms 977supporting

confidence: 87%

“…MSrelated disabilities are a likely explanation for this poorer QoL. This has been reported for a number of disabilities, such as fatigue [4][5][6], cognitive and emotional functioning [7], depression [4,5,8,9], chronic pain [10], and bladder and sexual dysfunction [11].…”

Section: Introductionmentioning

confidence: 87%

The impact of disabilities on quality of life in people with multiple sclerosis

et al. 2008

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“…3,4 This problem is of great interest in the comprehensive care of MS patients, particularly as HRQOL and adjustment to illness may help predict disease progression 4 (eg, through influencing susceptibility to relapses, engagement in positive health behaviors, use of active coping strategies, and so on). Previous research in MS has shown associations between poor HRQOL and progressive disease course, [5][6][7][8][9] greater physical disability, [10][11][12][13][14][15] disease duration, 10 fatigue, 11,12,16,17 and depression. 3,6,[17][18][19][20][21] Of these, physical and cognitive capacity are measured by performance-based reliable measures, and it is not clear which ability domain is most critical for poor HRQOL in MS patients.…”

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confidence: 96%

Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Hoogs

Kaur

Smerbeck

et al. 2011

International Journal of MS Care

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Many studies have shown that multiple sclerosis (MS) has a significant impact on patient healthrelated quality of life (HRQOL), but the relative contributions of physical versus cognitive disability are not well established. Most studies have relied on HRQOL outcomes that depend largely on patient mood, life satisfaction, and personal happiness. The Sickness Impact Profile (SIP) is a measure of HRQOL known for its relatively strong emphasis on task completion and activities of daily living. As such, the SIP may be less influenced by depression. We sought to determine the relative influence of physical disability and cognition, above and beyond demographic and disease variables, in predicting HRQOL. Patients (n = 132) and healthy controls (n = 26) underwent complete neuropsychological evaluation using the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery and a series of self-report measures assessing depression, fatigue, and HRQOL. The SIP was also administered. Correlation analysis and group comparisons revealed significant associations between cognition and HRQOL outcomes. Logistic regression models comparing the Expanded Disability Status Scale (EDSS) and cognitive tests in predicting poor physical HRQOL retained both EDSS and Symbol Digit Modalities Test (SDMT) performance, while models predicting poor psychosocial and poor overall HRQOL retained only the SDMT. These findings support cognition as a significant predictor of overall HRQOL, psychosocial HRQOL, and, interestingly, physical HRQOL. Int J MS Care. 2011;13:57-63.

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“…Patients with higher BDI (Beck Depression Inventory) scores displayed lower scores on all MSQOL-54 scales. This finding is in accordance with the results of another Italian study (Patti et al, 2003). Janardhan et al (Janardhan and Bakshi, 2002) assessed the QoL of 60 consecutive MS patients with the MSQOL-54 instrument.…”

Section: V3 Factors Influencing Health-related Quality Of Lifesupporting

confidence: 87%

Long-term immunomodulatory treatment and quality of life of patients with multiple sclerosis

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Health-related quality of life and depression in an Italian sample of multiple sclerosis patients

Cited by 107 publications

References 31 publications

The impact of disabilities on quality of life in people with multiple sclerosis

The impact of disabilities on quality of life in people with multiple sclerosis

Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Long-term immunomodulatory treatment and quality of life of patients with multiple sclerosis

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