Health-related quality-of-life and behavioural outcome in survivors of childhood meningitis

Sumpter, Ruth E.; Brunklaus, Andreas; McWilliam, Robert; Dorris, Liam

doi:10.3109/02699052.2011.613090

Cited by 35 publications

(31 citation statements)

References 18 publications

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“…Previous studies reported that ACNS’ survivors should be screened for emotional and behavioral difficulties, even if most patients fall within normal ranges on behavioral measures [ 8 ]. Identifying internalizing disorders may predict the risk of anxiety disorders in the future.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

et al. 2017

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BackgroundAcute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors.MethodsThe study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesù Children Hospital, Rome from June 2013 till June 2015. The patients and their parents underwent a psychological interview and neuropsychological tests during the first week of hospital admission and 1 year after, during a follow-up control. Wilcoxon signed rank tests for paired data were conducted to verify if the results were statistically importance. Patients underwent a cognitive profile test through the Leiter international performance scale – revised, motor skills evaluation through the test of visual-motor integration and a psychopathological evaluation by the child behavior checklist. The K-SADS-PL test was administered in children 6-11 years old to check psychopathological disorders.ResultsForty-four patients were included in the study. At the 1 year follow-up, “anxiety problems” (dependency, fears, worries, nervousness) developed in 47% of patients, “somatic problems” (aches, headaches, nausea, vomiting) in 29% and “affective problems” (crying, self-harming, worthlessness, guilt, tiredness, sadness) in 29%. Visual perception was statistically increased at the 1 year follow-up in our patient cohort (p = 0.0297), mainly among the meningitides group (p = 0.0189). Motor-coordination also increased at the follow-up check in the study participants (p = 0.0076), especially in the group affected by cerebellitis (p = 0.0302).ConclusionsNeuropsychological disorders are often difficult to recognize in the early stage. They must, however, be promptly identified through specific and standardized neuropsychological examinations in order to avoid long term sequelae in adulthood.

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Section: Discussionmentioning

confidence: 99%

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

et al. 2017

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“…Of the 17 full-text articles on which data extraction was performed (see Table 1), 4 dealt with anogenital warts [15][16][17][18], 3 with influenza [19][20][21], and 5 with the impact of meningitis, though these are classified in Table 1 according to the causative agents, which included Haemophilus influenzae type B [22], meningococcal meningitis [23], bacterial meningitis in general [22,24], and pneumococcal disease [25,26]. Of the studies dealing with bacterial meningitis in general, one dealt with pneumococcal and bacterial meningitis but excluded that caused by H. influenzae type B [24] and the other dealt with bacterial meningitis caused by any of the three pathogens mentioned [22]. In addition, we found four studies in rotavirus [27][28][29][30] and one in patients with varicella [31].…”

Section: Resultsmentioning

confidence: 99%

Assessing Patient-Reported Outcomes in Pediatric Populations With Vaccine-Preventable Infectious Diseases: A Systematic Review of the Literature (the PROCHID Study)

et al. 2016

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“…Patients with meningitis, interestingly, had higher MCS-12 scores. This was unexpected, as one would expect a central nervous system infection to negatively impact psychological outcomes [ 12 ]. However, it is possible that meningitis, which may not require surgery or as long of an OPAT course and may have been due to conditions such as neuroborrelliosis or neurosyphilis, has lower cumulative impacts on patients.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Outpatient Parenteral Antimicrobial Therapy

Keller

Williams²,

Levering

et al. 2018

Open Forum Infectious Diseases

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Health-related quality-of-life and behavioural outcome in survivors of childhood meningitis

Cited by 35 publications

References 18 publications

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

Assessing Patient-Reported Outcomes in Pediatric Populations With Vaccine-Preventable Infectious Diseases: A Systematic Review of the Literature (the PROCHID Study)

Health-Related Quality of Life in Outpatient Parenteral Antimicrobial Therapy

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