Health-Related Quality of Life and Utility in Patients With Age-Related Macular Degeneration

Sahel, José‐Alain; Bandello, Francesco; Augustin, Albert J.; Maurel, F.; Negrini, C; Berdeaux, G

doi:10.1001/archopht.125.7.945

Cited by 38 publications

(25 citation statements)

References 50 publications

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“…The construct validity of the EQ-5D, TTO, and SG was assessed by testing a priori hypotheses relating utility scores with clinical indices of disease severity. Current literature shows that utility measures (eg, TTO and SG) correlate better with disease indices than generic health status instruments (eg, EQ-5D), 5,16,[18][19][20][21] and clinical AMD severity correlates poorly on utility measures and EQ-5D. 22,23 Therefore, we hypothesised that (1) EQ-5D would correlate weakly to moderately well with VA and clinical AMD severity, (2) TTO and SG would show a moderate to strong correlation with VA, but null to weak correlation with clinical AMD severity.…”

Section: Statistical Analysesmentioning

confidence: 99%

Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population

Eong

Chan

Luo

et al. 2012

Eye

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Background/aims Utility values of agerelated macular degeneration (AMD) in Asian patients are unknown. This study aims to assess utility values and construct validity of the EuroQOL-5D (EQ-5D), time trade-off (TTO), and standard gamble (SG) instruments in the Singapore multi-ethnic AMD population. Methods Cross-sectional, two-centre, institution-based study. Visual acuity (VA), clinical AMD severity, and utility scores on the EQ-5D, TTO, and SG were obtained from 338 AMD patients. VA was analysed in terms of the better-seeing eye (BEVA), worse-seeing eye (WEVA), and weighted average of both eyes (WVA). We evaluated SG on the perfect healthdeath (SG(death)) and binocular perfect vision-binocular blindness (SG(blindness)) scales. Construct validity was determined by testing a priori hypotheses relating the EQ-5D, TTO, and SG utility scores to VA and clinical AMD severity. Results The mean utilities on the EQ-5D, TTO, SG(death), and SG(blindness) were 0.89, 0.81, 0.86, and 0.90, respectively. EQ-5D scores correlated weakly with BEVA, WEVA, and WVA (Pearson's correlation coefficients À0.291, À0.247, and À0.305 respectively, Po0.001 for all). SG(death) and SG(blindness) demonstrated no correlation with BEVA, WEVA, or WVA (Pearson's correlation coefficients, range À0.06 to À0.125). TTO showed weak association only with WEVA and WVA (correlation coefficients À0.237, À0.228, Po0.0001), but not with BEVA (correlation coefficient À0.161). Clinical AMD

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Section: Statistical Analysesmentioning

confidence: 99%

Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population

Eong

Chan

Luo

et al. 2012

Eye

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“…The 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) is a 25-item generic, vision-related QoL instrument that has already been used with AMD [10,11]. …”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients Suffering from Active Exudative Age-Related Macular Degeneration: The EQUADE Study

et al. 2015

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Purpose: Age-related macular degeneration (AMD) is the main cause of visual loss in the elderly population. With the use of anti-vascular endothelial growth factor, the visual outcomes of exudative AMD patients have been improved. This study was aimed at assessing the quality of life (QoL) of exudative AMD patients treated with ranibizumab and at determining its drivers in a real-life setting. Methods: We performed a national, cross-sectional, observational survey based on questionnaires sent to members of French associations relative to AMD between December 2012 and March 2013. Patients suffering from exudative AMD with at least one intravitreal injection of ranibizumab within the last 6 months were included. Demographics, AMD characteristics, visual acuity (VA) and past and ongoing treatments were collected. The 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) was self-administered. A multivariate model was used to identify QoL drivers. Results: 416 questionnaires fulfilled the complete criteria for both QoL and cost analyses. The mean age of exudative AMD patients was 78.0 years and bilateral involvement was reported in 60.4%. The overall mean QoL score was 53.4. Mental health, driving and role difficulties were the most widely affected domains. After bivariate analyses, long-term illness status, worse VA and higher number of unpaid aids were associated with worse QoL, with odds ratios of 2.4, 5.2 and 11.6, respectively. The mean cost per year and per patient was 1,741 EUR. The main components of costs were aids and services and the purchase of visual equipment. Conclusions: The main predictors of QoL in exudative AMD patients treated with ranibizumab are VA outcomes, home healthcare and social services provided to the patients.

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“…A crosssectional European study of best eye and worst eye visual acuity in patients with age-related macular degeneration (ARMD) showed that vision loss is strongly associated with decreased health-related quality of life. 1 This calls for the primary eye care provider to address treatment options for the whole person, not just the eye disease. For patients with visual impairment, low vision services are an essential part of the treatment plan.…”

Section: The Need For Vision Rehabilitationmentioning

confidence: 99%

An overview of multidisciplinary rehabilitation for age-related macular degeneration at the Henry Ford Center for Visual Rehabilitation and Research

Deol¹

2012

OPTO

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Age-related macular degeneration (ARMD) is a leading cause of legal blindness in the United States. With the aging population increasing in numbers, there is a greater need for comprehensive low vision services. Visual impairment from ARMD can affect all aspects of living, from safety to well-being to participation in everyday and leisure activities. Low vision intervention is necessary for individuals with ARMD complaining of difficulty with any activities of daily living, so that such difficulties may be addressed. This paper outlines the multidisciplinary model for ARMD rehabilitation at the Henry Ford Center for Vision Rehabilitation and Research, located in the Metropolitan Detroit area, MI, designed to address all aspects of seniors' lives affected by visual impairment, allowing them to live fully and independently.

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Health-Related Quality of Life and Utility in Patients With Age-Related Macular Degeneration

Abstract: To assess the impact of best-eye and worst-eye visual acuity (BEVA and WEVA, respectively) on health-related quality of life and utility in patients with wet age-related macular degeneration.

Cited by 38 publications

References 50 publications

Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population

Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population

Quality of Life in Patients Suffering from Active Exudative Age-Related Macular Degeneration: The EQUADE Study

An overview of multidisciplinary rehabilitation for age-related macular degeneration at the Henry Ford Center for Visual Rehabilitation and Research

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