Health-related Quality of Life and Its Relationship to Patient Disease Course in Childhood-onset Systemic Lupus Erythematosus

Brunner, Hermine I.; Higgins, Gloria C.; Wiers, Kristina; Lapidus, Sivia; Olson, Judyann C.; Onel, Karen; Punaro, Marilynn; Ying, Jun; Klein‐Gitelman, Marisa S.; Seid, Michael

doi:10.3899/jrheum.081164

Cited by 69 publications

(89 citation statements)

References 25 publications

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“…Our previous research also found jSLE patients to have lower school functioning compared to healthy children (11). Our current study suggests that this decrement is even larger in obese jSLE than non-obese jSLE patients.…”

Section: Discussionmentioning

confidence: 63%

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Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus

Mina

Klein-Gitelman

Nelson

et al. 2014

Lupus

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Objective Evaluate the effects of obesity on health-related quality of life (HRQOL) measures in juvenile-onset SLE (jSLE). Methods Obesity was defined as a body mass index (BMI) ≥ 95th% according to the sex-specific Center for Disease Control body mass index-for-age charts and determined in a multicenter cohort of jSLE patients. In this secondary analysis, the domain and summary scores of the Pediatric Quality of Life (PedsQL) Inventory and the Child Health Questionnaire (CHQ) of obese jSLE patients were compared to those of non-obese jSLE patients as well as historical obese and non-obese healthy controls. Mixed-effects modeling was performed to evaluate the relationship between obesity and HRQOL measures. Results Among the 202 jSLE patients, 25% (n=51) were obese. Obesity had a significant negative impact on HRQOL in jSLE, even after adjusting for differences in current corticosteroid use, disease activity, disease damage, gender, and race between groups. Obese jSLE patients had lower physical functioning compared to non-obese jSLE patients, and to non-obese and obese healthy controls. Compared to their non-obese counterparts, obese jSLE patients also had worse school functioning, more pain, worse social functioning, and emotional functioning. Parents of obese jSLE patients worry more. The CHQ scores for obese jSLE patients were also worse compared to non-obese jSLE patients in several other domains Conclusion Our study demonstrates the detrimental effects of obesity on patient-reported outcomes in jSLE. This supports the importance of weight management for the therapeutic plan of jSLE.

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Section: Discussionmentioning

confidence: 63%

“…Our previous research showed that jSLE patients as a group have lower physical functioning domain scores compared to healthy children (11). This study builds on this earlier report and suggests that this is especially true for obese jSLE patients.…”

Section: Discussionmentioning

confidence: 97%

Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus

Mina

Klein-Gitelman

Nelson

et al. 2014

Lupus

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“…When considering the parent or patient perception of jSLE improvement as an external standard, the SRI and PCI both had very low sensitivity despite high specificity. This may be because patients/parents assign different importance to certain disease features compared to the treating physicians, as we have previously reported 29. This finding also suggests that additional patient-reported outcomes are needed to be included in future jSLE clinical trials in order to capture patient and parent-perceived treatment effects adequately 30…”

Section: Discussionmentioning

confidence: 83%

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

et al. 2013

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“…The patients may be categorized based on their disease condition, gender, ethnicity, socioeconomic status, and access to or quality of care. Healthrelated quality of life in SLE has been compared with that of controls [26,[58][59][60], groups with other rheumatologic disorders [61], and groups with chronic diseases [58]. Demography-based comparisons have been attempted.…”

Section: Discriminative Patient-reported Outcome Studiesmentioning

confidence: 99%

Pitfalls and Opportunities in Measuring Patient Outcomes in Lupus

Jolly

2010

Curr Rheumatol Rep

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Health outcomes and their measures used as end points in systemic lupus erythematosus (SLE) patient care and clinical trials have been varied and are still evolving. Although significant reductions in morbidity and mortality in SLE have been achieved, the medications approved for SLE have remained the same during the past 50 years. Despite the pressing need, aggressive advocacy in the community, and advances in drug development and testing in SLE, no medications have met US Food and Drug Administration guidelines for a new indication claim approval for SLE. This may be attributable to its multisystemic, remitting, and relapsing nature, and difficulty in identifying useful end points and appropriate tools to measure them. Thus, it is pivotal to identify and validate appropriate global, disease-specific, and perhaps organ-specific health outcomes for clinical research. This article reviews recent physician- and patient-generated health outcomes in SLE.

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Health-related Quality of Life and Its Relationship to Patient Disease Course in Childhood-onset Systemic Lupus Erythematosus

Cited by 69 publications

References 25 publications

Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus

Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

Pitfalls and Opportunities in Measuring Patient Outcomes in Lupus

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