Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores

Benzing, Christian; Krezdorn, Nicco; Förster, Julia; Hinz, Andreas; Krenzien, Felix; Atanasov, Georgi; Schmelzle, Moritz; Hau, Hans-Michael; Bartels, Michael

doi:10.1016/j.hpb.2016.01.546

Cited by 19 publications

(26 citation statements)

References 44 publications

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“…In the current literature, there are numerous studies analysing the psychosocial factors in LT recipients [7, 15, 17, 18]. …”

Section: Discussionmentioning

confidence: 99%

“…All p -values <0.05 were indicated as being of a statistical significance.

Note: This study has partially analysed data of a large cross-sectional study of transplant candidates and transplant recipients. In parts, it has been previously published [7, 8, 23, 24] . However, these publications considered different inclusion criteria and used a different patient subset (e.g.

…”

Section: Methodsmentioning

confidence: 99%

“…In parts, it has been previously published [7, 8, 23, 24] . However, these publications considered different inclusion criteria and used a different patient subset (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…It is well-known that transplantation improves the HRQoL, as well as the mental status, when compared to those patients on an LT waiting list [7, 11]. However, there are currently only a few examinations that have focused on these particular outcome variables among Re-LT recipients [9, 12–14].…”

Section: Introductionmentioning

confidence: 99%

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Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study

Broschewitz

Wiltberger

Krezdorn

et al. 2017

Health Qual Life Outcomes

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BackgroundLiver Retransplantation (Re-LT) procedures are associated with an increased risk of morbidity and mortality. Up to date, there is no knowledge on the health-related quality of life and the mental status of these patients.MethodsHealth-Related Quality of Life (HRQoL) was assessed by using the Short Form 36 (SF-36) Health Survey and Mental Status was assessed by using the Hospital Anxiety and Depression Scale (HADS). The patients were examined in different assessments: During regular check-up examinations in the LT outpatient department in 2011 (Survey 1) and in a postal survey in 2013 (Survey 2). Their medical data was collected by using an established database.ResultsWe received eligible surveys of 383 patients (55.6%) with a history of LT, of which 15 (3.9%) had undergone Re-LT (Re-LT group). These patients were compared to a group of 60 patients who had undergone only one LT. With regard to their HRQoL, the Re-LT group had significantly lower scores on the scales of physical function (PF, p = 0.026), their role-physical (RP, p = 0.008), their vitality (VIT, p = 0.040), and their role-emotional (RE, p = 0.005). The scores for anxiety and depression did not differ significantly between the groups. In a multiple regression analysis, chronic kidney disease was found to be an independent risk factor for decreased scores of PF (p = 0.023).ConclusionsPatients who have to undergo Re-LT procedures are faceing impairments in physical aspects of a HRQoL. Together with clinical results from other studies, the findings of the present examination underline the need for an optimized organ distribution strategy since not all patients listed for Re-LT appear to benefit from it.

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“…In the current literature, there are numerous studies analysing the psychosocial factors in LT recipients [7, 15, 17, 18]. …”

Section: Discussionmentioning

confidence: 99%

“…All p -values <0.05 were indicated as being of a statistical significance.

…”

Section: Methodsmentioning

confidence: 99%

“…In parts, it has been previously published [7, 8, 23, 24] . However, these publications considered different inclusion criteria and used a different patient subset (e.g.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study

Broschewitz

Wiltberger

Krezdorn

et al. 2017

Health Qual Life Outcomes

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“…So far, data have been previously published in parts. [27][28][29][30] Nonetheless, these publications focused on different inclusion criteria and used a different patient subset (eg, patients who have history of liver transplant vs patients on wait lists). Here, we initially report on the recipients of a liver and kidney transplant, thus providing crucial new insights in this field.…”

Section: Statistical Analysesmentioning

confidence: 99%

Untitled

Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

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Objectives: To date, fatigue is still poorly understood in recipients of orthotopic liver transplant and simultaneous/sequential liver and kidney transplant procedures. The present study examined the appearance of fatigue in patients who received orthotopic liver and sequential liver and kidney transplant procedures compared with the general population and the influence of various clinical and socioeconomic factors on fatigue levels. Materials and Methods: The Multidimensional Fatigue Inventory survey was sent to all patients with a history of orthotopic liver and simultaneous/sequential liver and kidney transplant. The results were compared to data from a reference population. Results: Our survey included 276 eligible patients: 256 recipients (92.7%) of orthotopic liver transplant and 20 recipients (7.3%) of simultaneous/sequential liver and kidney transplant. Significantly lower fatigue scores were found in the general population compared with both transplant groups (P < .001). There were also no significant differences between the transplant groups. Among the clinical and socioeconomic factors, history of hepatocellular carcinoma, chronic kidney disease, age, family status, and education had a significant impact on fatigue levels. Conclusions: This is the first study to compare fatigue in recipients of orthotopic liver and simultaneous/-sequential liver and kidney transplant. We found that fatigue is an important but still poorly understood outcome after transplant.

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Health-Related Quality of Life and Patient Reported Outcome Measures Following Transplantation Surgery

Papalois

2023

Patient Reported Outcomes and Quality of Life in Surgery

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Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores

Abstract: Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.

Cited by 19 publications

References 44 publications

Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study

Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study

Untitled

Health-Related Quality of Life and Patient Reported Outcome Measures Following Transplantation Surgery

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