Health-related quality of life as a prognostic factor of survival in critically ill patients

Iribarren-Diarasarri, S.; Aizpuru-Barandiaran, Felipe; Muñoz-Martínez, T.; Loma-Osorio, A; Hernández-López, M.; Ruiz-Zorrilla, José María; Castillo-Arenal, Carlos; Dudagoitia-Otaolea, Juan Luis; Martínez-Alutiz, S.; Vinuesa-Lozano, C.

doi:10.1007/s00134-009-1418-3

Cited by 29 publications

(13 citation statements)

References 36 publications

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“…Recently, interest in the human genetic susceptibility to infection has increased (53,54). Similar findings were previously reported in critically ill patients with multisystem organ dysfunction syndrome (55,56). These studies are not included here because they did not define a septic subgroup.…”

Section: Discussionsupporting

confidence: 72%

Long-term mortality and quality of life in sepsis: A systematic review*

Winters¹,

Eberlein²,

Leung³

et al. 2010

Critical Care Medicine

535

397

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Patients with sepsis have ongoing mortality beyond short-term end points, and survivors consistently demonstrate impaired quality of life. The use of 28-day mortality as an end point for clinical studies may lead to inaccurate inferences. Both observational and interventional future studies should include longer-term end points to better-understand the natural history of sepsis and the effect of interventions on patient morbidities.

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Section: Discussionsupporting

confidence: 72%

Long-term mortality and quality of life in sepsis: A systematic review*

Winters¹,

Eberlein²,

Leung³

et al. 2010

Critical Care Medicine

535

397

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“…A recent review on mortality in elderly ICU patients concluded that, after adjustment for disease severity, ICU and post-ICU mortality rates are higher in elderly patients than in younger populations [117]. Their long-term prognosis depends mostly on functional status, not on initial disease severity [117,118]. In fact, a recent prospective study in a cohort of previously healthy elderly ICU patients documented a high mortality rate which increased with age, and was mostly related to premorbid quality of life [119].…”

Section: Ethical Perspectivementioning

confidence: 99%

Kidney injury: the case of elderly patients

et al. 2011

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approach. AKI treatment in this age group may be even more complex than in the general population. There are data on differences in renal recovery and mortality between the young and the old with renal injury which indicate a higher risk in fragile elderly individuals. Furthermore, it is crucial to establish all possible measures for AKI prevention in the elderly critically ill patient, since once AKI is established, mortality increases significantly.Riassunto Nella popolazione anziana il rischio di danno renale acuto (AKI) è elevato. Il numero di ricoveri di persone anziane in terapia intensiva (ICU) è in crescente aumento e di conseguenza il danno renale acuto acquisito in comunità e in ospedale sta diventando sempre più frequente. Molti cambiamenti legati all'età rendono questi soggetti maggiormente esposti allo sviluppo di insufficienza renale acuta. Talvolta è difficile porre precocemente la diagnosi nell'aziano ricoverato in ICU, e nuovi biomarcatori, come l'ENGAL, posso offrire nuove possibilità. Il trattamento dell'insufficienza renale acuta in questa classe di età può essere anche più complesso che nella popolazione generale. Dati comparativi sul recupero renale e sulla mortalità tra la popolazione giovane e nella terza età dimostrano un maggiore rischio per gli individui anziani fragili. Inoltre, é cruciale definire tutte le possibili misure di prevenzione dell'insufficienza renale acuta nei pazienti critici oltre i 60 anni, poiché una Summary There is a high risk of acute kidney injury (AKI) in the elderly population. The demand for intensive care unit (ICU) admission from older patients is rising, and with it community and hospital acquired AKI are becoming more frequent. Several age-related changes render elderly patients prone to AKI development. The most frequent aetiologies for renal impairment in these patients are recent surgery, sepsis and dehydration. It is sometimes difficult to achieve an early diagnosis in the elderly ICU patient, and new biomarkers such as neutrophil gelatinase-associated lipocalin may offer a new

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“…The authors demonstrated a twofold higher risk for in-hospital (P = 0.04) mortality and 1-year mortality (P = 0.001) in case of moderate to severe impairment of a patient's quality of life (QoL) within the month prior to ICU admission [1]. Although we appreciate these interesting findings, we would like to raise some comments.…”

mentioning

confidence: 92%

“…To the Editor, With great interest, we read the article by Iribarren-Diarasarri et al [1] who made commendable efforts to investigate whether a patient's health status prior to intensive care unit (ICU) admission can be used as a prognostic factor to assess an individual's mid to long-term prognosis. The authors demonstrated a twofold higher risk for in-hospital (P = 0.04) mortality and 1-year mortality (P = 0.001) in case of moderate to severe impairment of a patient's quality of life (QoL) within the month prior to ICU admission [1].…”

mentioning

confidence: 99%