Health-Related Quality of Life as a Prognostic Factor in Patients After Resection of Hepatic Malignancies

Tohme, Samer; Sanin, Gloria D; Patel, Vishaal; Bress, Kathryn; Ahmed, Naadia; Krane, Andrew; Tsung, Allan; Steel, Jennifer L.

doi:10.1016/j.jss.2019.07.061

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Factors known to influence QoL in cancer patients are, among others, age, gender, cancer type, performance status, and high symptom burden [10][11][12][13]. In patients with hepatic malignancies, specifically, extrahepatic recurrence is of significant influence on QoL [14]. To form an impression of the influence of RE on QoL, we performed a systematic review of the literature (See Figure S1 for the search strategies).…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients with liver tumors treated with holmium-166 radioembolization

Roekel

Smits

Prince

et al. 2019

Clin Exp Metastasis

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Holmium-166 radioembolization is a palliative treatment option for patients with unresectable hepatic malignancies. Its influence on quality of life has not been evaluated yet. Since quality of life is very important in the final stages of disease, the aim of this study was to evaluate the effect of holmium-166 radioembolization on quality of life. Patients with hepatic malignancies were treated with holmium-166 radioembolization in the HEPAR I and II studies. The European Organization for Research and Treatment of Cancer QLQ-C30 and LMC21 questionnaires were used to evaluate quality of life at baseline, 1 week, 6 weeks and at 6, 9 and 12 months after treatment. The course of the global health status and symptom and functioning scales were analyzed using a linear mixed model. Quality of life was studied in a total of 53 patients with a compliance of 94%. Role functioning was the most affected functioning scale. Fatigue and pain were the most affected symptom scales. Changes in almost all categories were most notable at 1 week after treatment. A higher WHO performance score at baseline decreased global health status, physical functioning, role functioning and social functioning and it increased symptoms of fatigue, dyspnea and diarrhea. Quality of life in salvage patients with liver metastases treated with holmium-166 radioembolization was not significantly affected over time, although a striking decline was seen during the first week post-treatment. A WHO performance score > 0 at baseline significantly influenced quality of life.

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Section: Introductionmentioning

confidence: 99%

Quality of life in patients with liver tumors treated with holmium-166 radioembolization

Roekel

Smits

Prince

et al. 2019

Clin Exp Metastasis

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“…Baseline HRQoL has been shown to be associated with survival postoperatively in the setting of hepatic resection for both primary and secondary liver malignancies [ 38 , 39 ]. As reported by Rees et al, weight loss, abdominal pain, altered taste, fatigue, and problems with sex life were all factors associated with poorer survival in patients treated with liver resection for CRC liver metastases [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy

et al. 2022

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Liver transplantation (LT) for patients with non-resectable colorectal liver metastases (CRLM) offers improved survival and has gained increased interest internationally the last years. The aim of this study was to describe the health-related quality of life (HRQoL) in patients with non-resectable CRLM receiving LT and how baseline HRQoL factors affect overall survival (OS). HRQoL data in the SECA (SEcondary CAncer) LT cohort was compared to data obtained from colorectal cancer patients starting first-line chemotherapy for metastatic disease in a clinical trial and data from a Norwegian normal population. HRQoL data from the QLQ-C30 questionnaire used in the SECA LT study and the NORDIC- VII study were reported. The relationship between patient-reported symptom burden at baseline and OS was investigated. In the SECA study longitudinal HRQoL assessment was used to describe the time until definitive deterioration as well as mean values at different time points. Patients in the SECA and NORDIC-VII studies reported similar baseline HRQoL. The median time until definitive deterioration in the transplanted patients was estimated to 36 months. In the SECA study appetite loss and pain at baseline had negative impact on OS (25.3 versus 71.7 months, p = 0.002 and 39.7 versus 71.7 months, p = 0.038, respectively). Despite a relapse in most of the LT patients the Global Health Score (GHS) remained good. Pain, and especially appetite loss at time of transplantation is associated with poor outcome after LT.

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“…The expansion of vaccination programs, as seen in Pakistan with support from the Global Alliance for Vaccines and Immunization, marks a positive step forward, though the focus on newborns suggests that significant improvements in public health will take time to manifest. This research is a call to action for enhancing environmental conditions and fostering stronger community bonds to effectively tackle the transmission and consequences of hepatitis B and C, thereby reducing the incidence of liver cancer and related mortality rates globally (12,13).…”

Section: Introductionmentioning

confidence: 99%

Self Determination, Decision Making and Social Functioning as a Prognostic Factor among Hepatitis ‘B’ and ‘C’ Patients

Waqas,

Khan,

Saeed

2024

JHRR

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Background: Viral hepatitis, encompassing hepatitis B and C, remains a significant public health challenge globally, with a vast majority of those affected unaware of their infection status. The societal stigma and lack of awareness about these diseases impede early diagnosis and effective management, particularly in developing regions. Patient self-help groups and public health initiatives play a critical role in bridging the knowledge gap and facilitating access to care. Objective: This study aimed to evaluate the impact of patient self-help groups in Punjab, Pakistan, on raising awareness and enhancing the management of hepatitis B and C. It sought to assess the effectiveness of awareness campaigns and the role of healthcare professionals in disease identification and management. Methods: A mixed-methods approach was employed, incorporating both qualitative and quantitative data collection through surveys distributed among 150 participants, including 102 males and 48 females from rural and urban areas. The survey consisted of three parts: an evaluation of patient self-help groups, liver disease awareness campaigns, and public health initiatives' commitment against viral hepatitis. Data analysis was performed using SPSS version 25, focusing on the correlation between demographic variables, awareness levels, and the impact of educational campaigns. Results: The findings revealed a significant correlation between awareness levels and participation in self-help groups (r=.564, p<.000). Urban participants showed slightly lower awareness scores (Mean=81.69, SD=14.00 for Total1; Mean=121.81, SD=19.52 for Total2) compared to rural participants (Mean=82.27, SD=12.10 for Total1; Mean=125.75, SD=17.73 for Total2). Gender analysis indicated higher awareness among females (Mean=83.56, SD=13.65 for Total1; Mean=125.60, SD=19.21 for Total2) than males (Mean=81.42, SD=12.11 for Total1; Mean=124.20, SD=17.89 for Total2). Despite the efforts of patient groups, a gap in healthcare professionals' knowledge about viral hepatitis was noted, with no specialized training programs available for general practitioners. Conclusion: The study underscores the crucial role of patient self-help groups and targeted awareness campaigns in improving the management and awareness of hepatitis B and C in Punjab. However, the lack of knowledge among healthcare professionals about viral hepatitis highlights the need for comprehensive training programs. Enhancing public health strategies and educational initiatives could significantly contribute to early disease detection and management, reducing the burden of viral hepatitis.

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Health-Related Quality of Life as a Prognostic Factor in Patients After Resection of Hepatic Malignancies

Cited by 8 publications

References 39 publications

Quality of life in patients with liver tumors treated with holmium-166 radioembolization

Quality of life in patients with liver tumors treated with holmium-166 radioembolization

Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy

Self Determination, Decision Making and Social Functioning as a Prognostic Factor among Hepatitis ‘B’ and ‘C’ Patients

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