Health-Related Quality of Life Based on EQ-5D Utility Score in Patients With Tuberculosis: A Systematic Review

Park, Hae Young; Cheon, Hyo-Bin; Choi, Sun Ha

doi:10.3389/fphar.2021.659675

Cited by 14 publications

(17 citation statements)

References 27 publications

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“…Participants with open fractures and no signs of infection reached the preinjury EQ-5D-3L baseline level at 12 months; however, participants with open tibial fractures who developed infection after surgery had both delayed radiographic healing and the lowest EQ-5D-3L scores at 6 (0.77) and 12 months (0.87) out of all subgroups analyzed 15,24 . We reported a mean EQ-5D-3L index score of 0.76 for those affected by an infected nonunion, comparable with scores for similarly aged participants living with chronic diseases such as HIV (human immunodeficiency virus) and untreated tuberculosis in other LMICs 27,28 . Further, these lower quality-of-life scores are consistent with findings in the literature describing the chronic burden of nonunion and infection complicating open tibial shaft fractures in higher-income countries 29-34 .…”

Section: Discussionsupporting

confidence: 56%

Outcomes of Intramedullary Nailing and External Fixation of Open Tibial Fractures

Cortez

Urva

Haonga

et al. 2022

Journal of Bone and Joint Surgery

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Background:While surgeons in low and middle-income countries have increasing experience with intramedullary nailing (IMN), external fixation (EF) continues to be commonly used for the management of open tibial fractures. We examined outcomes with extended follow-up of the participants enrolled in a clinical trial comparing these treatments.Methods:Adults who were ≥18 years old with acute AO/OTA type-42 open tibial shaft fractures were randomly assigned to statically locked, hand-reamed IMN or uniplanar EF. These participants were reevaluated 3 to 5 years after treatment. The primary outcome was death or reoperation for the treatment of deep infection, nonunion, or malalignment. Unresolved complications such as persistent fracture-related infection, nonunion, or malalignment were collected and analyzed. Secondary outcomes included the EuroQol-5 Dimension-3 Level (EQ-5D-3L) questionnaire, the Function IndeX for Trauma (FIX-IT) score, radiographic alignment, and the modified Radiographic Union Scale for Tibial fractures (mRUST).Results:Of the originally enrolled 240 participants,126 (67 managed with IMN and 59 managed with EF) died or returned for follow-up at a mean of 4.0 years (range, 2.9 to 5.2 years). Thirty-two composite primary events occurred, with rates of 23.9% and 27.1% in the IMN and EF groups, respectively. Six of these events (3 in the IMN group and 3 in the EF group) were newly detected after the original 1-year follow-up. Unresolved complications in the form of chronic fracture-related infection or nonunion were present at long-term follow-up in 25% of the participants who sustained a primary event. The EQ-5D-3L index scores were similar between the 2 groups and only returned to preinjury levels after 1 year among patients without complications or those whose complications resolved.Conclusions:This observational study extended follow-up for a clinical trial assessing IMN versus EF for the treatment of open tibial fractures in sub-Saharan Africa. At a mean of 4 years after injury, fracture-related infection and nonunion became chronic conditions in nearly a quarter of the participants who experienced these complications, regardless of reintervention.Level of Evidence:Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

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Section: Discussionsupporting

confidence: 56%

Outcomes of Intramedullary Nailing and External Fixation of Open Tibial Fractures

Cortez

Urva

Haonga

et al. 2022

Journal of Bone and Joint Surgery

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“…The effectiveness of testing strategies was evaluated in terms of the quality-adjusted life-year (QALY), estimated using the utility and duration of time spent in each of the health states 33 . The health utility weights of TBI were not significantly different from those of the healthy general population 34,35 . Hence, the utility model input of TBI adopted the age-specific health utility (0.92 for age 18-65 years), previously generated by the -related quality of life study using the US national health measures and surveys 36 .…”

Section: Methods Model Designmentioning

confidence: 63%

Cost effectiveness analysis of single and sequential testing strategies for tuberculosis infection in adults living with HIV in the United States

Fekadu

Yao

You

2022

Sci Rep

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Tuberculosis infection (TBI) frequently progresses to tuberculosis (TB) disease in people co-infected with human immunodeficiency virus (HIV). We examined the cost-effectiveness of single, sequential and no testing (total 12) strategies of TBI in HIV-infected people from the perspective of US healthcare provider. A decision-analytic model (20-year timeframe) was constructed to simulate TB-related outcomes: Direct medical cost and quality-adjusted life-years (QALYs). In the base-case analysis, the “confirm negative TST followed by QFT-Plus” strategy gained 0.1170 QALY at a total cost of USD3377. In the probabilistic sensitivity analysis of 10,000 Monte Carlo simulations, the probability of “confirm negative TST followed by QFT-Plus” to be accepted as cost-effective was the highest of all 12 strategies when the willingness-to-pay threshold exceeded 2340 USD/QALY. In conclusion, the strategy of “confirm negative TST followed by QFT-Plus” appears to be the preferred cost-effective option for TBI testing in HIV-infected people from the US healthcare provider’s perspective.

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“…A 36-item Short Form (SF-36 v2) survey questionnaire will be completed to assess the quality of life at baseline 26. The SF-36 form was chosen as it evaluates the patient’s health status across eight dimensions, making it suitable for an in-depth assessment of the patient’s health-related quality of life (HRQOL) 27. Enrolled patients will be provided with health cost diaries for continuously documenting their healthcare utilisation and any associated costs during the follow-up period.…”

Section: Methods and Analysismentioning

confidence: 99%

“…26 The SF-36 form was chosen as it evaluates the patient's health status across eight dimensions, making it suitable for an in-depth assessment of the patient's healthrelated quality of life (HRQOL). 27 Enrolled patients will be provided with health cost diaries for continuously documenting their healthcare utilisation and any associated costs during the follow-up period. This will include the number and duration of visits to tertiary hospitals, district hospitals and clinics.…”

Section: Enrolment and Baseline Assessmentmentioning

confidence: 99%

Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial

Velen

Nguyen

et al. 2022

BMJ Open

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IntroductionMultidrug-resistant tuberculosis (MDR-TB) remains a major public health problem globally. Long, complex treatment regimens coupled with frequent adverse events have resulted in poor treatment adherence and patient outcomes. Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to improve patient care and management; however, clinical trial evidence to support their use is lacking. This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice.Methods and analysisA community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. Patients commencing therapy for microbiologically confirmed rifampicin-resistant or multidrug-resistant tuberculosis within the past 30 days will be recruited to the study. Participants will be individually randomised to an intervention arm, comprising use of an mHealth application for treatment support, or a ‘standard care’ arm. In both arms, patients will be managed by the national TB programme according to current national treatment guidelines. The primary outcome measure of effectiveness will be the proportion of patients with treatment success (defined as treatment completion and/or bacteriological cure) after 24 months. A marginal Poisson regression model estimated via a generalised estimating equation will be used to test the effect of the intervention on treatment success. A prospective microcosting of the intervention and within-trial cost-effectiveness analysis will also be undertaken from a societal perspective. Cost-effectiveness will be presented as an incremental cost per patient successfully treated and an incremental cost per quality-adjusted life-year gained.EthicsEthical approval for the study was granted by The University of Sydney Human Research Ethics Committee (2019/676).DisseminationStudy findings will be disseminated to participants and published in peer-reviewed journals and conference proceedings.Trial registration numberACTRN12620000681954.

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Health-Related Quality of Life Based on EQ-5D Utility Score in Patients With Tuberculosis: A Systematic Review

Cited by 14 publications

References 27 publications

Outcomes of Intramedullary Nailing and External Fixation of Open Tibial Fractures

Outcomes of Intramedullary Nailing and External Fixation of Open Tibial Fractures

Cost effectiveness analysis of single and sequential testing strategies for tuberculosis infection in adults living with HIV in the United States

Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial

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