Health-related quality of life deficits associated with diabetes and comorbidities in a Canadian National Population Health Survey

Maddigan, Sheri L.; Feeny, David; Johnson, Jeffrey

doi:10.1007/s11136-004-6640-4

Cited by 169 publications

(129 citation statements)

References 38 publications

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“…Estimates of mean utility in diabetes have ranged widely, from 0.69±0.39 in a study of 372 rural patients with type 2 diabetes in Alberta, Canada [12], to a mean of 0.89-0.90 in population surveys in Ontario [11,33]. Our sample mean of 0.60±0.32 and median of 0.70 is in line with, but slightly lower than, results from other studies and represents a large Interpretation of age-and sex-adjusted models: the parameter represents the utility penalty incurred by an age-and sex-standardised patient with the specified clinical variable.…”

Section: Discussionmentioning

confidence: 99%

Correlates of health-related quality of life in type 2 diabetes

et al. 2006

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Aims/hypothesis: We assessed the impact of medical comorbidities, depression, and treatment intensity on quality of life in a large primary care cohort of patients with type 2 diabetes. Methods: We used the Health Utilities Index-III, an instrument that measures healthrelated quality of life based on community preferences in units of health utility (scaled from 0=death to 1.0=perfect health), in 909 primary care patients with type 2 diabetes. Demographic and clinical correlates of health-related quality of life were assessed. Results: The median health utility score for this population was 0.70 (interquartile range 0.39-0.88). In univariate analyses, older age, female sex, low socioeconomic status, cardiovascular disease, microvascular complications, congestive heart failure, peripheral vascular disease, chronic lung disease, depression, insulin use and number of medications correlated with decreased quality of life, while obesity, hypertension and hypercholesterolaemia did not. In multiple regression analyses, microvascular complications, heart failure and depression were most strongly related to decreased healthrelated quality of life, independently of duration of diabetes; in these models, diabetes patients with depression had a utility of 0.59, while patients without symptomatic comorbidities did not have a significantly reduced quality of life. Treatment intensity remained a significant negative correlate of quality of life in multivariable models. Conclusions/interpretation: Patients with type 2 diabetes have a substantially decreased quality of life in association with symptomatic complications. The data suggest that treatment of depression and prevention of complications have the greatest potential to improve health-related quality of life in type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Correlates of health-related quality of life in type 2 diabetes

et al. 2006

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“…5,[16][17][18]20,[22][23][24][25][26][27][28][29][30][31][32] All cost data were expressed in Canadian dollars and were inflated to 2015 using the Statistics Canada Consumer Price Index for health care and personal items. 33 Treatment efficacy and safety inputs were generated directly from the network meta-analysis model.…”

Section: Model Parametersmentioning

confidence: 99%

Drug therapies for chronic hepatitis C infection: a cost-effectiveness analysis

et al. 2017

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“…Nevertheless, the majority of adults with diabetes have at least one comorbid chronic disease (87)(88)(89), and conditions such as depression, chronic pain (90 -92), heart failure, and dementia often make diabetes self-care goals such as regular exercise and medication adherence almost impossible to attain (93). People may be "a patient with diabetes" while they are in a doctor's office, but diabetes is low on the list of characteristics of how they would define themselves (well below mother, policeman, church member, African American, friend, etc.).…”

Section: Look Before You Leap (But Do Not Forget To Leap) Diabetes-fmentioning

confidence: 99%