Health-Related Quality of Life Effects of Modafinil for Treatment of Narcolepsy

Abstract

Modafinil significantly improves health-related quality of life in narcolepsy.

A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence

“…Detoxification remains an important research question because patients with cocaine withdrawal symptoms have poor clinical outcome (Kampman et al, 2001), and enhanced euphoric responses to cocaine (Newton et al, 2003;Sofuoglu et al, 2003). Modafinil promotes feelings of well-being (Beusterien et al, 1999) has clinical effects that are largely opposite to cocaine withdrawal symptoms, and blunts cocaine-induced euphoria. It is possible that the steady improvement seen in modafiniltreated patients (see Figure 1) reflects the effect of diminished reward on their cocaine use.…”

Efficacy and safety of modafinil (Provigil(R)) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study

“…[11][12][13] After 9 weeks of double blind treatment with 200 mg/day and 400 mg/day modafinil in two pivotal double blind studies of modafinil for the treatment of EDS in patients with narcolepsy, the mean SF-36 vitality scores significantly improved by 11 points and 13 points over the baseline scores. 14 The improvements in vitality found after treatment with modafinil were significant (p<0.05 compared with placebo) and were maintained during 40 weeks of subsequent open label treatment with modafinil.…”

Narcolepsy, idiopathic hypersomnolence and related conditions

“…There is established, well-evidenced guidance on treatment, especially with continuous positive airway pressure (CPAP). 1 However, given an incidence of at least 2% in the adult population, it is inevitable that clinicians from a range of specialties will see patients with OSA of whom up to 80% will be undiagnosed. Such patients may present in extremis in the emergency room or as outpatients with symptoms that mimic those of another disorder or with a comorbid condition that predisposes to OSA.…”

“…Despite a quality of life impact similar to Parkinson's disease (PD) 1 and significant individual and societal costs 2 it is often overlooked. A UK survey found median time from first symptom to diagnosis to be 10.5 years.…”