Health related quality of life and patient concerns in patients with osteoradionecrosis

Chieng, Chiew Ying; Davies, Anna; Aziz, Amy; Lowe, Derek; Rogers, Simon N.

doi:10.1016/j.bjoms.2021.02.011

Cited by 14 publications

(16 citation statements)

References 19 publications

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“…As a result, the questions that will be asked should include all of the patient's complaints and be as objective as possible. Given these considerations, Chieng et al [46] 's recently published study provided a unique opportunity to reflect on outcomes in routine care. Incorporation of patient-reported outcome measures (PROM) into standard follow-up in this study allowed for repeated measures with a 12year longitudinal assessment with few patients missed, as well as the opportunity to report patients' HRQoL before ORNJ diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, deep caries in the teeth and infection in the periodontal tissues begin, preparing the environment for the formation of ORNJ [43,44].Surgical resection can be used to control the infection in the ORNJ area and clear the necrotic tissue [45], but, daily functions such as nutrition, chewing, and speaking may be compromised due to bone deformation in the jaw, multiple tooth loss, and aesthetic and functional problems in the facial area,Because of facial deformities, the person may lose confidence and become socially isolated. According to Chieng and colleagues' research results in 109 patients with ORNJ, there were reductions in mood, anxiety, and overall QoL parameters in 28%, 30%, and 50% of these patients, respectively [46]. Anesthesia of the inferior alveolar nerve was one of the ORNJ presentation features observed in 7.4% of cases [47].…”

Section: The Influence Of Ornj-related Factors On Daily Life and Qol ...mentioning

confidence: 99%

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Quality of Life Changes in Patients with Osteoradionecrosis and Their Measurement

Somay

Yılmaz²,

Küçük³

et al. 2022

JAMMR

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One of the most serious and debilitating complications of radiation therapy (RT) for patients with head and neck cancer (HNC) is osteoradionecrosis of the jaws (ORNJ). ORNJ is defined as radiation-induced ischemic bone necrosis with soft tissue necrosis in the absence of primary tumor, recurrence, or metastatic disease. Even though the incidence of ORNJ has dropped from about 20% to 2–8% as a result of recent advancements in RT techniques, this serious complication is still very challenging to predict, prevent, and treat. It is beyond dispute that ORNJ has detrimental effects on patients' quality of life (QoL). Pain, halitosis, taste disturbance, dysesthesia or anesthesia, trismus, difficulty chewing, swallowing, feeding, and speaking, fistula formation, pathological fracture, and localized or systemic infections are the most frequent symptoms of ORNJ that have an impact on the victim's QoL measures. However, ORNJ-specific QoL studies are scarce in this patient group despite ORNJ's significant harmful effects on the sufferers' physical appearance and functions, mood, and social relationships. By providing readily available information about the physical, social, and emotional effects of ORNJ as measured by general or HNC-specific QoL surveys, this review article aims to serve as a foundation for future studies addressing novel ORNJ-specific questionnaires.

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Section: Discussionmentioning

confidence: 99%

Section: The Influence Of Ornj-related Factors On Daily Life and Qol ...mentioning

confidence: 99%

Quality of Life Changes in Patients with Osteoradionecrosis and Their Measurement

Somay

Yılmaz²,

Küçük³

et al. 2022

JAMMR

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“…The prevalence of which being between 5-15%, with the mandibular body being the commonest site affected following external beam radiotherapy (1). ORN can have a profound impact on health-related quality of life with issues often attributed to difficulties with trismus, pain, chewing, speaking, swallowing, and psychosocial wellbeing (2)(3)(4). Rates of ORN are likely to rise due to increasing incidence of oral and oropharyngeal cancer, frequent use of radiotherapy and chemoradiotherapy particularly in the Human Papilloma Virus positive groups (HPV), and growing numbers of long-term survivors (5,6).…”

Section: Introductionmentioning

confidence: 99%

Patients' experience and perceived concerns regarding obtaining and taking prescriptions for head and neck osteoradionecrosis

E¹,

Lim²,

Rogers³

2022

British Journal of Oral and Maxillofacial Surgery

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“…ORNJ may cause anemia, inflammatory infections, leukocytosis, hyperproteinemia, and hypercoagulation, rendering oncologic treatment more difficult in HNC patients [32]. Furthermore, ORNJ has a severe impact on the quality of life (QoL) of longterm HNC survivors [33], and the emergence of trismus and numbness following ORNJ therapy worsens QoL measures even more. Also, dietary restrictions, eating in public, speech intelligibility, halitosis, and an inability to communicate can all result in much lower QoL [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Challenges in Osteoradionecrosis of the Jaw

Yılmaz

Somay

Küçük

et al. 2022

JCTI

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Osteoradionecrosis of the jaws (ORNJ) is a severe radiotherapy (RT) complication that occurs in 2% to 22% of individuals with head and neck cancers (HNC) who are treated with RT or concurrent chemo-RT. The accurate diagnosis of ORNJ is crucial for appropriate and prompt management. On the other hand, various ORNJ stages can resemble osteomyelitis, medication-related osteonecrosis of the jaw (MRONJ), and tumor recurrences. This challenging situation is primarily due to the clinical and radiologic similarities between ORNJ and these non-RT-related conditions. Image analysis techniques such as panoramic imaging (PI), computed tomography (CT), magnetic resonance imaging (MRI), bone scintigraphy, positron emission tomography (PET), and single photon emission CT (SPECT) might help to avoid diagnostic obstacles. Despite the fact that the general characteristics of ORNJ have been reported in the literature, there is no clear consensus on its definitive diagnosis. Therefore, the current review aims to address ORNJ and its clinical and radiological aspects, as well as provide evidence to inform on the approaches to be used in removing the complexity in diagnosis, with a specific focus on radiological and nuclear medicine techniques.

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Health related quality of life and patient concerns in patients with osteoradionecrosis

Cited by 14 publications

References 19 publications

Quality of Life Changes in Patients with Osteoradionecrosis and Their Measurement

Quality of Life Changes in Patients with Osteoradionecrosis and Their Measurement

Patients' experience and perceived concerns regarding obtaining and taking prescriptions for head and neck osteoradionecrosis

Diagnostic Challenges in Osteoradionecrosis of the Jaw

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