“…Reduce travel time and frequency of attendance at outpatient clinics [44,82] Patient and healthcare professional acceptance of telemedicine [74,122] More frequent monitoring and contact with patients [48,49] Familiarity with technology [69,114] Reduce caregiver burden [101] Infrastructure costs [123] Improve QoL [40,47,92] Data security and reliability [119,121,122] Reduce attendance at primary care and emergency department [37,38,63,94] High-quality evidence to justify use [4,5,118] Reduce hospitalisations [36,38,63,64,79,94] An increase in workload to monitor large amounts of data [123] Increase patient empowerment with immediate feedback [69] Potential for long-term cost savings [46,87] Opportunity for big data analysis to answer outstanding questions in rare conditions [107] Key points…”