Health-related quality of life in type 2 diabetes mellitus patients with different risk for obstructive sleep apnea

Abstract

PurposeOur study primarily aimed to investigate health-related quality of life (HRQoL) in type 2 diabetes mellitus (T2DM) patients with different risk for obstructive sleep apnea (OSA).Patients and methodsThis cross-sectional, questionnaire-based study included 466 adult patients with T2DM on regular visit to Center for Diabetes of University Hospital of Split from April to September 2017. All subjects underwent detailed anamnestical evaluation and physical examination with anthropometric measurements. Additionally, all subjects completed STOP (Snoring, Tiredness, Observed apnea, and high blood Pressure) questionnaire to assess risk for OSA, Epworth Sleepiness Scale to assess daytime sleepiness, and Medical Outcomes Study Short Form-36 (SF-36) instrument to evaluate HRQoL.ResultsMost subjects (N=312, 67.0%) represented high-risk OSA group based on STOP questionnaire (STOP score ≥2). Statistically significantly lower HRQoL scores in all SF-36 dimensions were found in T2DM patients with high risk for OSA compared to low-risk group (P<0.001). STOP score showed statistically significant negative correlation with all SF-36 dimensions (P<0.001). In multiple linear regression analysis, STOP score was confirmed as statistically significant independent predictor for all SF-36 components, adjusted for body mass index, age, glycated hemoglobin, and T2DM duration (P<0.001).ConclusionOur study found that high proportion of patients with T2DM are at high risk for OSA. Furthermore, we showed that group of T2DM patients with high risk for OSA has lower HRQoL in all SF-36 dimensions compared to low-risk patients.

Health-related quality of life and associated factors among patients with type II diabetes mellitus: A study in the family medicine center (FMC) of Agricultural General Hospital in Hanoi, Vietnam

“…The relationship between diabetes and HRQoL is complex and can be affected by various factors in different contexts. Under this study, multivariate regression model confirmed that age was statistically significantly associated to both physical and mental component of HRQoL, which is consistent with previous studies ( Gabric et al, 2018 ; Wexler et al, 2006 ). Age is the strongest predictor among demographic, lifestyle, and clinical factors ( p < 0.0001).…”

“…Age is the strongest predictor among demographic, lifestyle, and clinical factors ( p < 0.0001). Similar findings have been reported in both European and Asian studies with inverse correlation of HRQoL and age ( Gabric et al, 2018 ; Wang and Yeh, 2013 ). In the fact that elderly people usually have more than one chronic conditions, which means that they might have cognitive complications and have to take multiple medications, which is one of many factors that impacts their physical and mental health ( Brown et al, 2004 ; Nguyen et al, 2018 ).…”

Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature

“…A prospective population-based study did show that people with type 2 diabetes and OSA have a higher risk of cardiovascular mortality (HR 2.37 [95% CI 1.16, 4.82]), compared with people with only type 2 diabetes or only OSA [ 22 ]. Finally, in addition to poorer health outcomes, OSA affects QoL in people with type 2 diabetes; those with OSA score lower in all domains of QoL questionnaires, compared with people with type 2 diabetes only [ 23 ].…”

Obstructive Sleep Apnea and Diabetes Mellitus: A Bitter Combo

“…30 It has also been shown in a study that the association of T2DM and OSA casts a toll on the health-related quality of life as assessed by the STOP questionnaire with the correlation being statistically significant. 31 Thus the confederated effects of these two entities are elephantine.…”