Health-related quality of life in patients with pharyngeal carcinoma: A five-year follow-up

Nordgren, Mats; Jannert, Magnus; Boysen, Morten; Ahlner-Elmqvist, Marianne; Silander, Ewa; Bjordal, Kristin; Hammerlid, Eva

doi:10.1002/hed.20334

Cited by 61 publications

(39 citation statements)

References 26 publications

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“…Studies with longer follow-up periods report no clinical significant improvements in QoL after 1 year, with physical functioning and role functioning deteriorating over time and emotional functioning and global health improving [37–39]. Findings in our sample on quality of life over time closely parallel these results.…”

Section: Discussionsupporting

confidence: 83%

Illness cognitions in head and neck squamous cell carcinoma: predicting quality of life outcome

Scharloo

Jong

Langeveld

et al. 2009

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Goals of workThis paper presents an observational study of the longitudinal effects of cancer treatment on quality of life (QoL) in patients treated for head and neck squamous cell carcinoma (HNSCC), and evaluated the contribution of patients' baseline illness cognitions to the prediction of QoL 2 years after diagnosis.Patients and methodsOne hundred seventy-seven patients eligible for primary treatment for HNSCC completed the Illness Perception Questionnaire-Revised at baseline and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30 at baseline, at 1-year and 2-year follow-ups.Main resultsCompared to baseline, patients reported better emotional functioning at both follow-ups (p < 0.001), worse social functioning at 12 months (p < 0.05), and better global health status at 24 months (p < 0.05). Patients' own implicit common sense beliefs about their illness added small but significant amounts of variance to the prediction of QoL after 2 years. Less belief in own behavior causing the illness predicted better functioning and better global health. Strong illness identity beliefs predicted worse functioning and worse global health. Negative perceptions about the duration of the illness (chronic timeline beliefs) and more negative perceived consequences also predicted worse QoL.ConclusionsOur results on the negative perceptions about the duration of the illness, perceived consequences, and high symptom awareness predicting worse QoL illustrate the detrimental effects of uncertainty and negative expectations about the future course of the illness. The identification of these cognitive factors provides possible targets for counseling strategies to assist patients in long-term adjustment to HNSCC.

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Section: Discussionsupporting

confidence: 83%

Illness cognitions in head and neck squamous cell carcinoma: predicting quality of life outcome

Scharloo

Jong

Langeveld

et al. 2009

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“…At baseline, expression of intense psycho-social complaints, 17 physical self-efficacy (i.e. higher self-perceived physical abilities), 17 and self-reported high physical functioning 24 were associated with increased survival.…”

Section: Baseline Assessmentmentioning

confidence: 98%

“…Uncertainty about the diagnosis and treatment was found to be a negative prognostic indicator, 17 as was being single, 17,18 poor cognitive function, 19 baseline fatigue, 20,24 and alcoholism. 21 Overall, or global, quality of life at the time of diagnosis was not associated with survival in any of the studies.…”

Section: Baseline Assessmentmentioning

confidence: 98%

“…Its results for this particular aspect were excluded however due to insufficient information being provided and inadequate methodology used to determine the association. 24…”

Section: Assessment After Treatmentmentioning

confidence: 99%

“…For example when using the same instrument (the EORTC QLQ C30) four studies each found a different psycho-social factor to be significantly associated with survival. 19,20,23,24 Finally, some of the studies 23,24 were not designed with survival as their primary outcome, and hence may result in further confounding.…”

Section: Shortcomings Of Studiesmentioning

confidence: 99%

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