Health-related quality of life in Italian patients with systemic lupus erythematosus. II. Role of clinical, immunological and psychological determinants

Doria, Andrea; Rinaldi, S.; Ermani, Mario; Salaffi, Fausto; Iaccarino, Leonardo; Ghirardello, Anna; Zampieri, Sandra; Libera, S Della; Perini, Giulia; Todesco, S

doi:10.1093/rheumatology/keh392

Cited by 127 publications

(118 citation statements)

References 24 publications

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“…In agreement with the present findings, Doria et al reported that with increasing age, SLE patients obtained lower scores in the physical and mental dimensions of QoL (10). In addition, Elhone et al performed a study on QoL in lupus patients during 15 years and concluded that age was negatively associated with QoL, especially the physical dimension (11).…”

Section: Discussionsupporting

confidence: 91%

Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Compared to the Healthy Population in Shiraz, Iran

et al. 2017

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Background: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are chronic and complex autoimmune diseases, involving multiple organs. Therefore, quality of life (QoL) in SLE and RA patients can be affected. The current study aimed to compare SLE and RA patients with the healthy population in terms of health-related QoL (HRQoL) in Shiraz, Iran. Methods: The present cross sectional, analytical study was performed on 100 SLE patients, 100 RA patients, and 200 healthy controls, who were referred to the rheumatology clinics (Motahari and Hafez clinics) of Shiraz University of Medical Sciences. Demographic data including age, gender, educational level, and disease duration were evaluated. The Persian-translated version of 36-item shortform health survey (SF-36) was used as a tool for evaluating HRQoL. For statistical analysis, Pearson's correlation test, t-test, and ANOVA were performed, using SPSS.

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Section: Discussionsupporting

confidence: 91%

Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Compared to the Healthy Population in Shiraz, Iran

et al. 2017

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“…Previous studies have identified psychosocial (e.g., social support) and behavioral variables (e.g., helplessness, coping with illness) as being associated with quality of life in patients with SLE (7)(8)(9)(10)(11). However, inconsistent results have been reported regarding the influence of disease activity and damage on quality of life.…”

Section: Introductionmentioning

confidence: 99%

Quality of life over time in patients with systemic lupus erythematosus

Kuriya¹,

Gladman²,

Ibanez³

et al. 2008

Arthritis & Rheumatism

134

108

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Objective. To determine whether quality of life in patients with systemic lupus erythematosus (SLE) measured by the Short Form 36 (SF-36) changes over time and which patient-and disease-related factors influence such change. Methods. SLE patients who had >6 SF-36 evaluations during followup were identified from a database. Outcomes were slopes of scores of the 8 SF-36 domains as well as the physical and mental component scores. Based on the direction of the slope, patients were designated as unchanged, improved, or worsened. Linear regression models were used to test the contribution of risk factors to slopes. Nonparametric tests were used to evaluate risk factors between patterns of clinical change. Results. A total of 146 patients had >6 SF-36 evaluations in 1,047 visits over a mean ؎ SD period of 8.2 ؎ 1.1 years. During the interval, the majority of patients showed no change in the SF-36 domains and only a small minority demonstrated improvement. Physical and mental component scores were unchanged in 84.3% and 87.7% of patients whereas 4.1% and 7.5% improved, respectively. According to slopes of the domains and summary scores, only physical functioning demonstrated a significant decrease over time. There were no lupus disease features associated with decline in physical functioning except for the presence of fibromyalgia. Conclusion. The SF-36 in SLE patients with established disease changed little over an 8-year period. Changes in the SF-36 were not affected by disease activity, steroids, or damage accumulation during the interval, but were affected by the presence of fibromyalgia.

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“…The importance of assessing HRQL in patients with chronic pain has been documented by our recent studies of patients with inflammatory rheumatic diseases (RA, psoriatic arthritis and ankylosing spondylitis) (70), systemic lupus erythematosus (81,82), symptomatic knee and hip osteoarthritis (69), postmenopausal women with vertebral fractures (83), and fibromyalgia (59). In comparison with healthy controls, all of the rheumatic conditions significantly impaired all eight health concepts of the SF-36 in both the physical and mental component, but the disease with the worst HRQL for these dimensions was RA (70).…”

Section: Health-related Quality Of Life Assessmentmentioning

confidence: 99%

“…In comparison with healthy controls, all of the rheumatic conditions significantly impaired all eight health concepts of the SF-36 in both the physical and mental component, but the disease with the worst HRQL for these dimensions was RA (70). Overall, the dimensions typically affected in inflammatory rheumatic diseases were physical functioning, limitations due to physical function, and bodily pain, whereas the level of perceived HRQL in patients with fibromyalgia seems to be explained more by their mental health than by their physical condition (59,69,70,(81)(82)(83). A number of pain-related quality of life selfadministered instruments have been constructed to evaluate pain-related functional disturbances in specific diseases or pain conditions in which the patient is asked to list the activities or tasks they regularly performed before the onset of pain but have since found difficult.…”

Section: Health-related Quality Of Life Assessmentmentioning

confidence: 99%

Pain assessment strategies in patients with musculoskeletal conditions

2012

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Valid and reliable assessment of pain is fundamental for both clinical trials and effective pain management. The nature of pain makes objective measurement impossible. Chronic musculoskeletal pain assessment and its impact on physical, emotional and social functions require multidimensional qualitative tools and healthrelated quality of life instruments. The recommendations concerning outcome measurements for pain trials are useful for making routine assessments that should include an evaluation of pain, fatigue, disturbed sleep, physical functioning, emotional functioning, patient global ratings of satisfaction, and quality of life. Despite the growing availability of instruments and theoretical publications related to measuring the various aspects of chronic pain, there is still little agreement and no unified approach has been devised. There is, therefore, still a considerable need for the development of a core set of measurement tools and response criteria, as well as for the development and refinement of the related instruments, standardized assessor training, the cross-cultural adaptation of health status questionnaires, electronic data capture, and the introduction of valid, reliable and responsive standardized quantitative measurement procedures into routine clinical care. This article reviews a selection of the instruments used to assess chronic musculoskeletal pain, including validated newly developed and well-established screening instruments, and discusses their advantages and limitations

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Health-related quality of life in Italian patients with systemic lupus erythematosus. II. Role of clinical, immunological and psychological determinants

Abstract: Anxiety, depression and joint pain seem to be the major determinants of HRQOL impairment in SLE patients. Damage seems to influence HRQOL mostly through depression.

Cited by 127 publications

References 24 publications

Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Compared to the Healthy Population in Shiraz, Iran

Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Compared to the Healthy Population in Shiraz, Iran

Quality of life over time in patients with systemic lupus erythematosus

Pain assessment strategies in patients with musculoskeletal conditions

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