Health-related quality of life in long-term survivors of childhood brain tumors: a population-based cohort study

Ljungman, Lisa; Remes, Tiina; Westin, Elisabeth; Huittinen, Alina; Lönnqvist, Tuula; Sirkiä, Kirsti; Rantala, Heikki; Ojaniemi, Marja; Harila, Marika; Lähteenmäki, Päivi; Arikoski, Pekka; Wikman, Anna; Harila‐Saari, Arja

doi:10.1007/s00520-022-06905-x

Cited by 16 publications

(26 citation statements)

References 41 publications

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“…Survivors of various cancers were included in 18 studies. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Twelve studies were of survivors of haematological cancers, [37][38][39][40][41][42][43][44][45][46][47][48] four of brain tumour survivors [49][50][51][52] and two of survivors of other cancers, that is, differentiated thyroid carcinoma 53 and head-and-neck rhabdomyosarcoma. 54 The period of diagnosis ranged from 1948 to 2013, but in most studies, it was between 1970 and 2010.…”

Section: Resultsmentioning

confidence: 99%

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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Section: Resultsmentioning

confidence: 99%

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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“…Eighty-nine articles [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , …”

Section: Resultsunclassified

Employment among Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

Godono

Felicetti

Conti

et al. 2022

Cancers

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To date, there are heterogeneous studies related to childhood cancer survivors’ (CCS) employment rates. Given the importance of this topic, we aimed to perform a systematic review and meta-analysis to investigate the prevalence of employment among CCS and to examine its association with socio-demographic and clinical factors. We followed the PRISMA guidelines to search for pertinent articles in relevant electronic databases. Eighty-nine articles comprising 93 cohorts were included. The overall prevalence of employment was 66% (CI: 95% 0.63–0.69). Subgroup meta-analyses showed that lower rates were found for central nervous system tumor survivors (51%, CI: 95% 0.43–0.59), and for CCS treated with cranial-radiotherapy (53%, CI: 95% 0.42–0.64) or haematopoietic stem-cell transplantation (56%, CI: 95% 0.46–0.65). The studies conducted in Asia highlighted employment rates of 47% (CI: 95%, 0.34–0.60). Univariate meta-regressions identified the following socio-demographic factors associated with higher rates of employment: a female gender (p = 0.046), a higher mean age at the time of investigation (p = 0.00), a longer time since diagnosis (p = 0.00), a higher educational level (p = 0.03), and a married status (p = 0.00). In conclusion, this systematic review and meta-analysis provides evidence that two-thirds of CCS are employed worldwide. Identifying vulnerable groups of CCS may allow for the design of multidisciplinary support strategies and interventions to promote employment in this population.

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“…Lumbar IVD degeneration is associated with low back pain [16,17]. A previous publication of the same BT survivor population showed a trend toward reporting increased pain compared to healthy controls, but this association did not reach signi cance [27]. Our results suggest that long-term BT survivors may be at risk for low back pain due to IVD degeneration later in life.…”

Section: Discussionmentioning

confidence: 52%

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

Grahn

Remes

Kivisaari

et al. 2022

Preprint

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Background: Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. With an increasing population of childhood BT survivors, the understanding of the long-term consequences of BT treatment is highlighted. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls. Methods: In this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5–33.1), 67 (mean age 28.4, range 16.2–43.5) survivors were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, high-intensity zone-lesions (HIZ), intervertebral disc protrusions, and extrusions. Groups were also compared for known risk factors of intervertebral disc degeneration. Results: Childhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p<0.001). Lumbar disc protrusions at L4-5 (p=0.02) and extrusions at L3-4 (p=0.04), L4-5 (p=0.004), and L5-S1 (p=0.01) were significantly more common in the BT group compared to the control group. BP correlated with a higher degree of IVD degeneration at Th12-L1 (p=0.01), L1-2 (p=0.01), and L3-4 (p=0.03). Survivors with a younger age at diagnosis had significantly lower Pfirrmann grades (p<0.01). Conclusions: Signs of early aging related to tumor treatment can be seen in the intervertebral discs of survivors. Disc degeneration was more severe in children treated in adolescence.

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Health-related quality of life in long-term survivors of childhood brain tumors: a population-based cohort study

Cited by 16 publications

References 41 publications

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Employment among Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

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