Health-related quality of life in intensive care survivors: Associations with social support, comorbidity, and pain interference

Langerud, Anne Kathrine; Rustøen, Tone; Småstuen, Milada Cvancarova; Kongsgaard, Ulf E.; Stubhaug, Audun

doi:10.1371/journal.pone.0199656

Cited by 30 publications

(25 citation statements)

References 65 publications

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“…The intensity of pain measured with BPI-SF was negatively correlated to both EQoL-5D/5L VAS and EQoL-5D/5L index value. This correlation has been described for many pathologies and usually related to an injury as a trigger of pain [32]. The EQoL-5D/5L index value and therefore, the reported HRQoL, was lower in those patients who reported a greater intensity of pain.…”

Section: Correlation and Clinically Signi Cant Painsupporting

confidence: 56%

Incidence of New-Onset Pain, Characteristics and Influence on Health-Related Quality of life in COVID-19 Survivors After Critical Illness. Analysis of the PAIN COVID Clinical Trial cohort.

Ojeda

Calvo

Cuñat

et al. 2020

Preprint

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Background: To explore the incidence and characteristics of new-onset pain, its impact on quality of life (HRQoL), and to quantify the presence of mood disorders in critically ill COVID-19 survivors. Methods: This is a preliminary report of PAIN-COVID clinical trial (NCT04394169) presenting a descriptive analysis in critical ill COVID 19 survivors one month after hospital discharge. Pain was assed using the Brief Pain Inventory short form, Douleur Neuropathique 4 Questions test and Pain Catastrophizing Scale. Health related quality of life (HRQoL) was evaluated with EQoL-5D/5L and mood disorders with Hospital Anxiety and Depression test (HAD).Results: From May 27th to July 19th 2020, 203 patients were consecutively screened for eligibility and 65 were finally included in this analysis. In 33 (50.8%) patients a new-onset pain was reported: 18 (54.5%) reported clinically significant intense pain, 11 (33.3%) a positive screening for neuropathic pain, 3 (9.1%) clinically relevant pain catastrophizing thoughts, 29 (87.9%) pain in ≥2 body sites and 5 (15.2%) widespread pain. Median EQoL-5D/5L index value and visual analogue scale was 0.8 (IQR 0.57-0.87) and 70 (IQR 60-80) respectively. Pain intensity was negatively correlated both to the former (Spearman Rho: -0.546, p<0.001) and to the latter (Spearman Rho: -0.387, p=0.001). A HAD anxiety and depression value over 8 were obtained in 7 (10,8 %) and 5 (7,7%) of patients, respectively.Conclusion: The incidence of new-onset pain in critically ill COVID-19 survivors is high and it was associated with a lower HRQoL. Trial registration: NCT04394169. Registered 19 May 2020. https://clinicaltrials.gov/ct2/show/NCT04394169

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Section: Correlation and Clinically Signi Cant Painsupporting

confidence: 56%

Incidence of New-Onset Pain, Characteristics and Influence on Health-Related Quality of life in COVID-19 Survivors After Critical Illness. Analysis of the PAIN COVID Clinical Trial cohort.

Ojeda

Calvo

Cuñat

et al. 2020

Preprint

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“…This cohort of COVID-19 ARDS patients revealed significantly lower scores in the motion and usual activities dimensions of the 15D instrument compared to both the contemporary Italian and the Finnish pre-COVID-19 populations. The reduction in terms of physical components of the HRQoL instruments is common in both ICU survivors [ 21 ] and non-COVID ARDS survivors [ 35 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some registered ongoing trials aim to define the quality of life after COVID-19 infection (ClinicalTrials.gov NCT04375709, NCT04377464) but these studies do not focus on critically ill patients [ 20 ]. Notably, health-related quality of life (HRQoL) [ 12 , 21 ] in “classical” ARDS survivors is impaired, as showed in previous studies.…”

Section: Introductionmentioning

confidence: 97%

Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up

et al. 2021

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Purpose The onset of the coronavirus disease 19 (COVID-19) pandemic in Italy induced a dramatic increase in the need for intensive care unit (ICU) beds for a large proportion of patients affected by COVID-19-related acute respiratory distress syndrome (ARDS). The aim of the present study was to describe the health-related quality of life (HRQoL) at 90 days after ICU discharge in a cohort of COVID-19 patients undergoing invasive mechanical ventilation and to compare it with an age and sex-matched sample from the general Italian and Finnish populations. Moreover, the possible associations between clinical, demographic, social factors, and HRQoL were investigated. Methods COVID-19 ARDS survivors from 16 participating ICUs were followed up until 90 days after ICU discharge and the HRQoL was evaluated with the 15D instrument. A parallel cohort of age and sex-matched Italian population from the same geographic areas was interviewed and a third group of matched Finnish population was extracted from the Finnish 2011 National Health survey. A linear regression analysis was performed to evaluate potential associations between the evaluated factors and HRQoL. Results 205 patients answered to the questionnaire. HRQoL of the COVID-19 ARDS patients was significantly lower than the matched populations in both physical and mental dimensions. Age, sex, number of comorbidities, ARDS class, duration of invasive mechanical ventilation, and occupational status were found to be significant determinants of the 90 days HRQoL. Clinical severity at ICU admission was poorly correlated to HRQoL. Conclusion COVID-19-related ARDS survivors at 90 days after ICU discharge present a significant reduction both on physical and psychological dimensions of HRQoL measured with the 15D instrument. Trial Registration: NCT04411459. Supplementary Information The online version contains supplementary material available at 10.1007/s11136-021-02865-7.

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“…Effective resuscitation and advancements in intensive care treatments have improved the survival rates of intensive care unit (ICU) patients over time (Gayat et al, 2018; Pun et al, 2019). However, ICU survivors still have high readmission and mortality rates, and often suffer from long‐term physical impairments; this renders them vulnerable to comorbidities and lowers their quality of life following hospital discharge (Bakhru et al, 2018; Langerud, Rustøen, Småstuen, Kongsgaard, & Stubhaug, 2018). Furthermore, patients in ICUs are likely to be sedated or physically restrained; this helps control their disruptive behavior and wandering, facilitates the continuation of treatment plans, and prevents them from falling off their beds (Azoulay et al, 2017; Bakhru et al, 2018).…”

mentioning

confidence: 99%

“…However, this could also lead to a decline in patients’ functional and cognitive states, causing ICU delirium, among other adverse effects (Brummel et al, 2015). Thus, functional and cognitive recovery by means of safe transition from intensive care is vital to improve ICU survivors’ health‐related quality of life (HRQoL; Detsky et al, 2018; Langerud et al, 2018).…”

mentioning

confidence: 99%

Gender Differences Regarding the Impact of Change in Cognitive Function on the Functional Status of Intensive Care Unit Survivors: A Prospective Cohort Study

Son

Song

Seo

2020

J of Nursing Scholarship

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Purpose This study aimed to identify gender differences with regard to the impact of change in cognitive function on functional status 3 months after receiving critical care. Design and Methods This prospective cohort study investigated 152 intensive care unit (ICU) patients. Their functional status and cognitive function were assessed using the validated Korean version of the Modified Barthel Index and Mini‐Mental State Examination, respectively. Hierarchical regression was used to evaluate the impact of change in cognitive function on functional status in ICU survivors by gender. Findings The proportion of women suffering from consistent cognitive impairment was significantly higher than that of men. Women had a rate of improvement to normal cognitive function within 3 months after discharge that was higher than that of men. Functional status 3 months after discharge was significantly lower for patients whose cognitive impairment was consistent than that for those whose cognitive function was normal. The impact of change in cognitive function on men (R2 change = .28) was greater than that on women (R2 change = .13). Conclusions Persistent cognitive impairment after critical illness had a negative effect on functional status in ICU survivors. Importantly, the negative impact of consistent cognitive impairment was greater in men than in women. Clinical Relevance Early careful assessment of functional and cognitive status after critical illness is warranted. Strategies addressing the gender‐specific characteristics related to cognitive improvement should also be developed.

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Health-related quality of life in intensive care survivors: Associations with social support, comorbidity, and pain interference

Cited by 30 publications

References 65 publications

Incidence of New-Onset Pain, Characteristics and Influence on Health-Related Quality of life in COVID-19 Survivors After Critical Illness. Analysis of the PAIN COVID Clinical Trial cohort.

Incidence of New-Onset Pain, Characteristics and Influence on Health-Related Quality of life in COVID-19 Survivors After Critical Illness. Analysis of the PAIN COVID Clinical Trial cohort.

Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up

Gender Differences Regarding the Impact of Change in Cognitive Function on the Functional Status of Intensive Care Unit Survivors: A Prospective Cohort Study

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