Health-related quality of life in people with advanced dementia: a comparison of EQ-5D-5L and QUALID instruments

Sopina, Elizaveta; Chenoweth, Lynn; Luckett, Tim; Agar, Meera; Luscombe, Georgina; Davidson, Patricia M.; Pond, Constance Dimity; Phillips, Jane; Goodall, Stephen

doi:10.1007/s11136-018-1987-0

Cited by 14 publications

(13 citation statements)

References 42 publications

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“…In particular, three model specifications were considered to predict the EQ-5D-5 L utility score mainly using MLHFQ total score (Model 1), MLHFQ domain scores (Model 2), or MLHFQ item scores (Model 3) (see below). Based on the previous literature [40,41], squared terms of MLHFQ total score, MLHFQ domain scores and MLHFQ item scores were added as independent variables to the linear modes (i.e. OLS, CLAD, MM) in order to account for the non-linear relationship between EQ-5D-5 L utility values and MLHFQ.…”

Section: Beta Regression Model (Beta)mentioning

confidence: 99%

Mapping the Minnesota living with heart failure questionnaire (MLHFQ) to EQ-5D-5L in patients with heart failure

Kularatna

Senanayake

Chen

et al. 2020

Health Qual Life Outcomes

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Background: Mapping algorithms can be used to convert scores from a non-preference based instrument to health state utilities. The objective of this study was to develop mapping algorithms which will enable the Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores to be converted into EQ-5D-5L utility scores that can be used in heart failure related cost utility studies. Method: Patients diagnosed with heart failure were recruited from Australia. Mapping algorithms were developed using both direct and indirect response mapping approach. Three model specifications were considered to predict the EQ-5D-5 L utility score using MLHFQ total score (Model 1), MLHFQ domain scores (Model 2), or MLHFQ item scores (Model 3). Six regression techniques, each of which has the capability to cope with either skewness, heteroscedasticity, ceiling effects and/or the potential presence of outliers in the data set were used to identify the optimal mapping functions for each of the three models. Goodness-of-fit of the models were assessed using six indicators. In the absence of an external validation dataset, predictive performance of was assessed using threefold cross validation method. In the indirect response mapping, EQ. 5D 5 L responses were predicted separately using the MLHFQ item scores using ordered logit model. Results: A total of 141 patients participated in the study. The lowest mean absolute error (MAE) was recorded from the multivariable fractional polynomials (MFP) model in all three-model specifications. Regarding the indirect response mapping, results showed that the performance was comparable with the direct mapping approach based on root mean squared error (RMSE) but was worse based on MAE. Conclusion: The MLHFQ can be mapped onto EQ-5D-5 L utilities with good predictive accuracy using both direct and indirect response mapping techniques. The reported mapping algorithms would facilitate calculation of health utility for economic evaluations related to heart failure.

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Section: Beta Regression Model (Beta)mentioning

confidence: 99%

Mapping the Minnesota living with heart failure questionnaire (MLHFQ) to EQ-5D-5L in patients with heart failure

Kularatna

Senanayake

Chen

et al. 2020

Health Qual Life Outcomes

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“…This analysis used trial-based outcomes and did not calculate the quality-adjusted life years (QALY) for comparison with other interventions. However, the outcomes used are caregiver-driven whereas the standard QALY does not consistently capture quality of life for a caregiver and person living with dementia (Sopina et al, 2019). This limits the comparison of our interventions to others that use the QALY.…”

Section: Discussionmentioning

confidence: 99%

Cost‐effectiveness of a telehealth intervention for in‐home dementia care support: Findings from the FamTechCare clinical trial

Shaw

Williams

Lee

et al. 2020

Research in Nursing & Health

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Determining the cost‐effectiveness of technological interventions is a crucial aspect in assuring these interventions can be adopted. The FamTechCare intervention is an innovative telehealth support that links family caregivers of persons living with dementia to tailored feedback from dementia care experts based on caregiver‐initiated video recordings of challenging care situations. The FamTechCare intervention has demonstrated significant reductions in caregiver depression and increases in caregiver competence when compared to standard telephone support. The purpose of this article is to report on the cost‐effectiveness of the FamTechCare telehealth intervention. Process‐based costing and a cost‐effectiveness analysis using the incremental cost‐effectiveness ratio (ICER) was completed with 68 caregiver and person living dementia with dyads. The cost of the 12‐week FamTechCare telehealth intervention was found to be greater ($48.43 per dyad per week) due to the telehealth equipment, recording application, and expert panel time compared with the telephone support intervention ($6.96 per dyad per week). The ICER was $18.51 for caregiver depression and $36.31 for caregiver competence indicating that it cost no more than $36.38 per dyad per week over 12 weeks to achieve significant improvement in depression and competence in the FamTechCare caregivers compared to the telephone support caregivers. The FamTechCare intervention appears to be cost‐effective when compared to the telephone support intervention and remains near the willingness‐to‐pay threshold for caregivers providing in‐home dementia care support.

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“…A recent systematic review found no significant difference in quality of life scores between family caregivers and staff proxy ratings for nursing home residents with dementia [ 43 ]. Although the EQ-5D is the preferred instrument to estimate utility scores in economic evaluations, it may not capture all important aspects of psychosocial care for advanced dementia [ 44 – 46 ]. Therefore, specific dementia outcomes, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, specific dementia outcomes, i.e. the QUALID and GAIN for family caregivers of persons with dementia, were also assessed in this study [46]. Last, a considerable amount of data was missing, which was accounted for by using multiple imputation; this is considered the most appropriate method to deal with missing data in economic evaluations [47].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Cost-effectiveness of the Namaste care family program for nursing home residents with advanced dementia in comparison with usual care: a cluster-randomized controlled trial

Alili

Smaling

Joling

et al. 2020

BMC Health Serv Res

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Background: Dementia is a progressive disease that decreases quality of life of persons with dementia and is associated with high societal costs. The burden of caring for persons with dementia also decreases the quality of life of family caregivers. The objective of this study was to assess the societal cost-effectiveness of Namaste Care Family program in comparison with usual care in nursing home residents with advanced dementia. Methods: Nursing homes were randomized to either Namaste Care Family program or usual care. Outcome measures of the cluster-randomized trial in 231 residents included Quality of Life in Late-Stage Dementia (QUALID) and the Gain in Alzheimer Care Instrument (GAIN) for family caregivers over 12 months of follow-up. Health states were measured using the EQ-5D-3L questionnaire which were translated into utilities. QALYs were calculated by multiplying the amount of time a participant spent in a specific health state with the utility score associated with that health state. Healthcare utilization costs were estimated using standard unit costs, while intervention costs were estimated using a bottom-up approach. Missing cost and effect data were imputed using multiple imputation. Bootstrapped multilevel models were used after multiple imputation. Cost-effectiveness acceptability curves were estimated.

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Health-related quality of life in people with advanced dementia: a comparison of EQ-5D-5L and QUALID instruments

Cited by 14 publications

References 42 publications

Mapping the Minnesota living with heart failure questionnaire (MLHFQ) to EQ-5D-5L in patients with heart failure

Mapping the Minnesota living with heart failure questionnaire (MLHFQ) to EQ-5D-5L in patients with heart failure

Cost‐effectiveness of a telehealth intervention for in‐home dementia care support: Findings from the FamTechCare clinical trial

Cost-effectiveness of the Namaste care family program for nursing home residents with advanced dementia in comparison with usual care: a cluster-randomized controlled trial

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