Health-related quality of life in patients with advanced colorectal cancer: results from a phase II study of S-1 combined with irinotecan (CPT-11)

Tsunoda, Akira; Yasuda, Naokuni; Nakao, Kentaro; Narita, Kentaro; Watanabe, Makoto; Matsui, Nobuaki; Tsunoda, Yuko; Kusano, Mitsuo

doi:10.1007/s10147-010-0059-4

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Tsunoda et al [21] also showed that overall HRQoL was not deteriorated within patients that received adjCT, only the short-term HRQoL was lower and caused by toxicity. And finally, Tsunoda showed a significant deterioration of HRQoL, however, this was HRQoL measured during treatment, in a small group of 37 colon cancer patients and it was defined as acceptable [8].…”

Section: Discussionmentioning

confidence: 99%

“…This review underlines that reasons for withholding chemotherapy are not always clear: in 15% the reason for withholding chemotherapy was not mentioned; and in 22% chemotherapy was 'not clinically indicated', although patients were eligible for adjCT [4,5]; also patients sometimes refuse chemotherapy themselves; or the presence of comorbid conditions and advanced age made one restrain from chemotherapy [4,6]. In a group of colon cancer patients, health related quality of life (HRQoL) is deteriorated after receiving chemotherapy [7,8]. Another paper focussing on long-term HRQoL, showed that colon cancer survivors who received adjCT have general health status scores comparable to survivors who did not receive adjCT [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Verhaar

Vissers

Maas

et al. 2015

European Journal of Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Verhaar

Vissers

Maas

et al. 2015

European Journal of Cancer

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“…22,24,31,33,47,49,71 ADJUVANT THERAPY Patients who underwent adjuvant chemotherapy after surgery reported worse body image than patients who did not at 1-and 2year follow-ups. 37,42,70…”

Section: Time From Surgerymentioning

confidence: 99%

Body Image Issues in Patients With Colorectal Cancer

Phung

Fang

2022

Cancer Nurs

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BackgroundStomas in colorectal cancer (CRC) survivors lead to body image problems. Advances in treatment help reduce the rate of stoma formation, but body image distress is still frequently experienced in CRC survivors.ObjectivesThis review is aimed toward mapping and describing the state of knowledge regarding body image in patients with CRC.MethodsA systematic literature search complying with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines was conducted. Screening and data extraction were performed by 2 reviewers independently for all potentially eligible studies.ResultsA total of 56 eligible articles were selected. The majority of these studies were quantitative studies (85%). The eligible studies were classified into 4 broad categories: instruments used to assess body image, prevalence of body image distress, factors related to body image, and impact of body image distress. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-CR38) colorectal questionnaire was the most common measurement tool found among the reviewed studies (70%), and body image distress was reported by 25.5% to 86% of participants. Excluding gender, age, type of surgery, adjuvant therapy, time from diagnosis, social support, and stoma status, changes in bowel habits was identified as affecting the body image of patients with CRC.ConclusionChanging bowel habits emerged as a significant factor causing body image distress for CRC survivors.Implications for PracticeClinicians should raise awareness about body image distress in patients with CRC, focus on finding effective measures and interventions intended to help alleviate symptoms of bowel dysfunction, and prepare patients to adapt to altered bowel functions.

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Effects of chemotherapy on the health-related quality of life of Japanese lower rectal cancer patients after sphincter-saving surgery

Kinoshita

Ohkusa

Izukura

et al. 2017

Journal of Psychosocial Oncology

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We examined the effects of adjuvant chemotherapy on the health-related quality of life (HRQOL) of lower rectal cancer patients receiving sphincter-saving surgery (SSS). In all, 109 patients completed a questionnaire before surgery and 1, 6, and 12 months afterwards. In the chemotherapy group, physical and social functioning scores were significantly lower 12 months after surgery compared with the nonchemotherapy group. These effects of adjuvant chemotherapy suggest that a different clinical approach might more effectively improve physical and social functioning in lower-rectal cancer patients undergoing chemotherapy. Healthcare providers should be alert for adverse events in patients with lower-rectal cancer and promptly address such conditions.

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Health-related quality of life in patients with advanced colorectal cancer: results from a phase II study of S-1 combined with irinotecan (CPT-11)

Abstract: Combined treatment with S-1 plus CPT-11 resulted in an acceptable deterioration in HRQOL functioning and symptoms, compared with baseline levels.

Cited by 7 publications

References 31 publications

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Body Image Issues in Patients With Colorectal Cancer

Effects of chemotherapy on the health-related quality of life of Japanese lower rectal cancer patients after sphincter-saving surgery

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