Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis

Abstract

BackgroundThe purpose of this study was to explore health-related quality of life (HRQOL) among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their quality of life (QOL) using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness.MethodsThis study was based on 4-year-data obtained from the KNHANES 2008 to 2011. Osteoporosis was diagnosed in 2,078 survey participants according to their bone mineral density measurements using dual energy X-ray absorptiometry. According to the World Health Organization study group, T-scores at or above -1.0 are considered normal, those between -1.0 and -2.5 as osteopenia, and those at or below -2.5 as osteoporosis The EuroQol five-dimensional questionnaire (EQ-5D) index score was used to assess the QOL.ResultsOf 2,078 patients diagnosed with osteoporosis, fractures were found to occur at 11.02%. Wrist fracture was the most frequent, affecting 4.52% of the patients, with a significantly different prevalence among men and women (P<0.001). The overall EQ-5D index score was 0.84±0.01 among patients with osteoporosis. With the exception of cancer, the EQ-5D index score were significantly lower for those having osteoarthritis, rheumatoid arthritis, hypertension, diabetes, chronic obstructive pulmonary disease and cardiovascular events compared to those without the related diseases.ConclusionsWe found that low health utility was associated with previous spine fracture and comorbidities in patients with osteoporosis. In particular, the number of fracture experiences greatly deteriorated the HRQOL in patients with osteoporosis. Thus, prevention of secondary fractures and chronic care model for comorbidities should be a priority for osteoporosis management in order to improve HRQOL.

Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008–2011

“…The main factor for low HRQOL in patients with osteoporosis is osteoporosis-related fractures, particularly vertebral fractures. [ 31 32 ] However, there is a paucity of data regarding osteoporosis with HRQOL in COPD patients. Osteoporosis-related fractures may play an important role in poor HRQOL in COPD patients.…”

Denosumab Treatment Improved Health‐Related Quality of Life in Osteoporosis: A Prospective Cohort Study

“…Previous studies reported a decrease in HRQOL among patients with knee osteoarthritis . Other studies have identified previous spinal fractures and comorbidities as factors associated with low health utility . Guillemin et al showed that a higher number of comorbidities was associated with a reduced HRQOL.…”

“…(35,36) Other studies have identified previous spinal fractures and comorbidities as factors associated with low health utility. (37,38) Guillemin et al (38) showed that a higher number of comorbidities was associated with a reduced HRQOL. These reports supported our findings that the existence of knee osteoarthritis and multiple comorbidities reduced HRQOL, Regardless of of denosumab treatment.…”

A Missed Opportunity to Prevent Subsequent Fractures Confirmed through Trends in the Treatment of Osteoporosis in Patients with Distal Radius and Hip Fractures

“…Osteoporosis and OFs (i.e., DRFs, HFs, spine, and humerus fractures) are becoming more important health problems in the elderly [13]. OFs reduce quality of life and cause medical expenses in the elderly [14,15].…”