“…First, given that the study was designed to examine predictors of patient-centered outcomes available in primary care practices, we had little information on traditional risk factors, such as co morbidity, hypercholesterolemia, left ventricular dysfunction, etc. Although we cannot rule out that left ventricular dysfunction may have confounded the results, evidence for an impact of left ventricular dysfunction on patient-centered outcomes, such as quality of life, anxiety and depressive symptoms, is mixed, with some (Bjelland et al 2002; de Rivas et al 2008) but not all studies (Lewis et al 2007; Schiffer et al 2008a, b, 2005) supporting such a relationship. Second, depressive symptoms were assessed by means of self-report rather than a clinical diagnostic interview.…”