Health-Related Quality of Life in Children and Adolescents with Epilepsy: A Systematic Review

Stevanović, Dejan; Tadić, Ivana; Novakovic, Tanja

doi:10.5772/17558

Cited by 18 publications

(29 citation statements)

References 78 publications

(68 reference statements)

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“…This checklist was modified for this review to suit its purpose. This checklist has been used in previous systematic reviews on the quality of life of people with different health conditions [6,[18][19][20]. One point was assigned to items that met the criteria.…”

Section: Quality Of Evidence Assessmentmentioning

confidence: 99%

The quality of life of older adults with epilepsy: A systematic review

Baranowski

2018

Seizure

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The aim of this systematic review is to identify and synthesise the current literature on the quality of life (QoL) of older adults with epilepsy. Studies were included if they (1) assessed the QoL of older adults (2) had a minimum of one population group of people with epilepsy aged 60 and older and (3) used a standardised QoL measure. Databases searched were PubMed, Scopus, Cochrane Library and PubPsych. A total of 201 abstracts were screened, of which 10 articles met the criteria. A 17-item standardised checklist was used to analyse the methodological quality of the studies. This checklist was derived from other systematic reviews which analysed the QoL of those with other health conditions and modified to suit the purpose of this review. The findings were synthesised to compare the overall QoL of older adults in comparison to younger age groups and to identify which QoL factors were the most and least negatively impacted by the presence of epilepsy and old age. Predictors of QoL were identified from findings that used a regression analysis and were rated regarding their strength of evidence. No clear differences for overall QoL were found between older and younger people with epilepsy. Participants reported energy/fatigue to be the most negatively impacted factor. Seizure frequency was a strong predictor of QoL, and comorbidity and depression were moderate predictors. The modest number of studies available for synthesis is a reflection of the gap in current literature on this topic. Future research needs to include more variables within their regression analysis to identify more predictors of QoL, and needs to compare QoL changes over the trajectory of older age.

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Section: Quality Of Evidence Assessmentmentioning

confidence: 99%

The quality of life of older adults with epilepsy: A systematic review

Baranowski

2018

Seizure

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“…Several systematic reviews conclude young people with epilepsy have higher levels of psychiatric diagnosis, externalizing and internalizing problems, lower health-related quality of life, social competence and poorer academic achievements, compared to their peers [4][5][6][7]. However, young people with epilepsy do not necessarily have negative outcomes.…”

Section: Introductionmentioning

confidence: 99%

Individual and family factors associated with self-esteem in young people with epilepsy: A multiple mediation analysis

Chew

Haase

Carpenter

2017

Epilepsy & Behavior

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. Individual and family factors associated with self-esteem in young people with epilepsy: A multiple mediation analysis. Epilepsy and Behavior, 66, 19-26. DOI: 10.1016/j.yebeh.2016.09.039 Peer reviewed version Link to publication record in Explore Bristol Research PDF-document This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://www.sciencedirect.com/science/article/pii/S1525505016303407. Please refer to any applicable terms of use of the publisher. University of Bristol -Explore Bristol Research General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms AbstractObjective: As young people experience added demands from living with epilepsy, which may lead to poor psychosocial adjustment, it is essential to examine mechanisms of change to provide practitioners with knowledge to develop effective interventions. The aim of this study was to examine individual and family-level factors -stress and illness perceptions, coping behaviours and family resilience -that promote or maintain young people's self-esteem.Methods: From November 2013 to August 2014, young people attending a neurology clinic in KK Women's and Children's Hospital, Singapore, participated in a cross-sectional survey (n=152; 13-16 years old). Multiple mediation analyses were conducted to evaluate whether these variables mediated the relationship between illness severity (i.e., low, moderate, high) and self-esteem.Results: Multiple mediation analyses demonstrated that illness severity had a direct effect on young people's self-esteem. Compared to those with moderate illness severity (reference group), young people with low severity had significantly higher self-esteem (c=3.42, p<0.05); while those with high severity had a more negative view of themselves (c=-3.93, p<0.001).Illness severity also had an indirect influence on self-esteem through its effects on mediators, such as perceived stress, illness perceptions and family resilience (D1: Total ab=3. 46, 95% CI 1.13, 5.71;). However, young people's coping levels did not predict their self-esteem, when accounting for the effects of other variables.Significance: The continued presence of seizure occurrences is likely to place greater demands on young people and their families: in turn, increased stress and negative illness perceptions, negatively affected family processes that promote resilience. As the mediating effect of these modifiable factors were above and beyond the contributions of illness characteristics and young people's levels of coping, this has implications for developing individual and family interventions aimed to support young people living with epilepsy.

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“…However, other variables have been previously reported to be significant risk factors affecting the HRQOL scale. [9] The type of medication administered, the epilepsy control over time, the severity of the seizure, and the underlying brain pathology, could all be important factors to consider in models studying the association between the adverse effects of AEDs and the HRQOL. Studies with a longer follow-up conducted on patients with newly diagnosed pediatric epilepsy (such as the one conducted Modi et al), [25] studies conducted on children on a changing AED regimen or on children with active epilepsy who were medicated for prolonged periods, are needed.…”

Section: Discussionmentioning

confidence: 99%

“…[11] A systematic review of studies on pediatric epilepsy published in 2011 showed that pediatric epilepsy has a significant influence on the HRQOL issues, particularly across the physical, psychological, social, and school-related domains. [9] Several studies have also investigated the effects of AEDs on HRQOL together with other epilepsy-related clinical and socio-demographic factors. The prevailing opinion is conflicting, with some studies showing that the numbers of AEDs (monotherapy vs. polytherapy) or their side effects are not related to the HRQOL; [12][13][14][15][16] while, several other studies have demonstrated that polypharmacy [17][18][19][20][21] and adverse effects of AEDs and the symptoms of their neurotoxicity, could considerably affect the HRQOL domains.…”

Section: Introductionmentioning

confidence: 99%

“…A recent review summarizing various studies related to this field has shown that AEDs may also have a negative impact on the child's well-being and daily functioning. [9] Over the past two decades, the impact of pediatric epilepsy and its co-morbidities on the lives of children has been occasionally evaluated using patient-reported outcomes (PRO) such as the health-related quality of life (HRQOL) index. [10] These studies have provided important data regarding the day-to-day living and functioning status of these children suffering from epilepsy.…”

Section: Introductionmentioning

confidence: 99%

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