Health-related quality of life in long-term disease-free breast cancer survivors versus female population controls in Germany

Doege, Daniela; Thong, Melissa S. Y.; Bertram, Heike; Eberle, Andrea; Holleczek, Bernd; Pritzkuleit, Ron; Waldeyer-Sauerland, Mechthild; Waldmann, Annika; Zeißig, Sylke Ruth; Jansen, Lina; Brenner, Hermann; Arndt, Volker

doi:10.1007/s10549-019-05188-x

Cited by 51 publications

(75 citation statements)

References 34 publications

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“…When compared to the general population, the HRQoL of the BCS measured by the 15D was impaired throughout the study period and did not reach the general population level even at the five-year follow-up. Similar results on the longterm impairment in QoL and HRQoL have been previously reported, although they have been somewhat conflicting (6)(7)(8)(9)(24)(25)(26)(27)(28). Several studies have revealed that especially i) sleep (6,7,24,27), ii) cognitive function (6,8,24,(27)(28), iii) fatigue (6,7,27), iv) emotional functioning (6,7,9,26) and v) mental health (6,9,27,29) remain impaired years after diagnosis and treatment.…”

Section: Discussionsupporting

confidence: 69%

“…A recent, large study with long-term (5-9 years postdiagnosis) and very-long term (≥10 years post-diagnosis) BCS has revealed overall QoL comparable to that of the general population, while significant detriments in almost all functioning and symptom scales existed. BCS had deficits in emotional and cognitive functioning, and persisting insomnia and fatigue measured using the EORTC-QLQC30 (6). Another study with very long-term BCS has also found similar QoL compared to age-matched controls in most respects, however, small deficits in cognition and finances were identified using the EORTC-QLQC30 (28).…”

Section: Discussionmentioning

confidence: 98%

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Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Roine

Sintonen

Kellokumpu‐Lehtinen

et al. 2020

In Vivo

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Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL) has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer survivors (BCS) in a prospective randomized exercise intervention study and to compare HRQoL to that of the agematched general female population. Patients and Methods: Following adjuvant treatment, 537 patients aged 35-68 and capable of exercise training were randomized to a 12-month exercise trial. In 182 of those patients, HRQoL was measured by the generic 15D at baseline and followed up for five years. Furthermore, the HRQoL of all BCS answering the 15D at five-year follow-up (n=390) was compared to that of a representative sample of the general population. Results: After five years, the BCS' mean HRQoL demonstrated a statistically and clinically significant impairment compared to that of the general population (difference-0.023, p<0.001). The mean HRQoL of BCS followed up from baseline until five years did not improve significantly (change=0.007, p=0.27), whereas the dimensions of usual activities (0.043, p=0.004), depression (0.038, p=0.007), distress (0.030, p=0.036), and sexual activity (0.057, p=0.009) did. Conclusion: The HRQoL of BCS was still impaired five years following treatment. The prognosis of breast cancer has improved dramatically during the last decades and this, together with an increasing incidence and an aging population, has led to a greater number of breast cancer survivors (BCS) (1, 2). The improved prognosis of breast cancer is largely due to early detection with comprehensive screening, and advanced surgical and adjuvant treatments. Adjuvant treatments of breast cancer clearly improve patients' survival, however, effective treatments have severe adverse effects that compromise patients' wellbeing (3-5). Consequently, many BCS suffer from numerous long-term cancer-and treatmentrelated adverse effects and impaired health-related quality of life (HRQoL) even years after the diagnosis and treatment (6-9). With an increasing population of BCS, it is essential to investigate their long-term perceived health and wellbeing and to identify those with impairments in HRQoL to be able to focus on their rehabilitation after breast cancer treatment. Studies focusing on HRQoL in breast cancer have often used disease-specific instruments (5, 10). Disease-specific 667 This article is freely accessible online.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 98%

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Roine

Sintonen

Kellokumpu‐Lehtinen

et al. 2020

In Vivo

View full text Add to dashboard Cite

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“…Consequently, many breast cancer survivors suffer from plenty of long-term, cancer-treatment-related late complications and side effects that impair health-related quality of life (HRQoL), many years after diagnosis and treatment [43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life Indicators in Patients Operated on for Breast Cancer in Relation to the Type of Surgery—A Retrospective Cohort Study of Women in Serbia

et al. 2020

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Background and objectives: Quality of life (QoL) after breast cancer surgery is an important public health issue. The aim of this study was to determine the relationship between the levels of perceived quality of life in patients operated on for breast cancer in relation to the type of surgery, using the standardized questionnaires. Materials and Methods: We assessed 425 women after surgery for breast cancer. The assessment included the application of the WHOQOL-bref (The World Health Organization Quality of Life-Bref), and FACT-B (Functional Assessment of Cancer Therapy-Breast) questionnaires. The statistical analysis of the data included multiple linear regression and correlation tests. Results: Multiple linear regression analysis found that education, existence of comorbidities, time elapsed since surgery, and type of surgery were significant predictors of overall quality of life. Women’s overall quality of life and general health has increased by 0.16 times for each subsequent year of surgery, and by 0.34 times for each subsequent higher education level. Breast-conserving surgery or mastectomy with breast reconstruction were statistically significant (β = 0.18) compared to total mastectomy. Conclusions: There is a significant difference in the quality of life perceived by patients in whom the breast has been preserved or reconstructed in relation to patients in whom total mastectomy has been performed.

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“…Some studies have indicated that breast cancer survivors have a significantly lower QoL, including lower physical, functional, emotional and social well-being compared to control-matched healthy populations and experience clinically relevant restrictions in several QoL dimensions 10 years after diagnosis, with restrictions in role, cognitive and social functioning and fatigue increasing over time [12,14]. While other studies have found that 10 years after diagnosis, many women report having a new meaning to their lives and healthier lifestyles, with long-term survivors having similar or improved QoL levels when compared to age-matched controls who have never had breast cancer [15,16].…”

Section: Introductionmentioning

confidence: 99%

The psychosocial determinants of quality of life in breast cancer survivors: a scoping review

et al. 2020

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Background Breast cancer care today involves state-of-the-art biomedical treatment but can fail to address the broader psychosocial and quality-of-life (QoL) issues associated with the transition to breast cancer survivorship. This scoping review examines the evidence on the influence of psychosocial determinants on QoL in breast cancer survivors. Methods Scoping review methodology was used to: (1) identify the research question(s); (2) identify relevant studies; (3) undertake study selection; (4) extract data; (5) collate, summarise and report the results. Results A total of 33 studies met the inclusion criteria. The majority of studies were conducted in the US (n = 22, 67%) and were mainly cross-sectional (n = 26, 79%). Sixteen psychosocial determinants of QoL were identified. Social support (n = 14, 42%), depression (n = 7, 21%) and future appraisal and perspective (n = 7, 21%) were the most frequently investigated determinants. Twelve different QoL measures were used. A range of different measurement tools were also used per psychosocial determinant (weighted average = 6). The 14 studies that measured the influence of social support on QoL employed 10 different measures of social support and 7 different measures of QoL. In general, across all 33 studies, a higher level of a positive influence and a lower level of a negative influence of a psychosocial determinant was associated with a better QoL e.g. higher social support and lower levels of depression were associated with a higher/better QoL. For some determinants such as spirituality and coping skills the influence on QoL varied, but these determinants were less commonly investigated. Conclusion Consensus around measures of QoL and psychological determinants would be valuable and would enable research to determine the influence of psychosocial determinants on QoL adequately. Research in other healthcare settings beyond the US is required, in order to understand the influence of organisation and follow-up clinical and supportive care on psychosocial determinants and QoL and to improve the quality of care in breast cancer survivors.

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Health-related quality of life in long-term disease-free breast cancer survivors versus female population controls in Germany

Cited by 51 publications

References 34 publications

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Quality of Life Indicators in Patients Operated on for Breast Cancer in Relation to the Type of Surgery—A Retrospective Cohort Study of Women in Serbia

The psychosocial determinants of quality of life in breast cancer survivors: a scoping review

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