Health-related quality of life in patients with non-functioning pituitary adenoma: a special focus on hydrocortisone replacement dose

Wild, Carl Mathis; Stieg, Mareike R.; Stalla, Günter; Auer, Matthias; Athanasoulia-Kaspar, Anastasia P.

doi:10.1007/s11136-020-02582-7

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…This observation could not be explained by a difference in depression or quality of life or anxiety scores, as no such difference could be established. This observation is in accordance with the results of our previous study, implying that patients with SAI did not have an impaired quality of life ( 10 ).…”

Section: Discussionsupporting

confidence: 93%

“…It is well known, that glucocorticoids are powerful circadian entrainers of peripheral clocks and the immune system is one of the most sensitive to this daily ‘reset’ ( 9 ). Patients with adrenal insufficiency report of increased fatigue and decreased quality of life ( 10 ) but also significant alterations in circadian gene expression compared to healthy controls ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Sleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study

et al. 2022

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PurposeIn this study we evaluate sleep patterns of patients treated for non-secreting intra- and parasellar tumors and age- and sex-matched healthy controls.MethodsWe conducted a self-report cross-sectional case-control study with 104 patients treated for non-secreting intra- and parasellar tumors and 1800 healthy controls in an 1:8 matching. All subjects answered the Munich ChronoType Questionnaire, whereas patients were provided the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale, the Short-Form 36 Health survey, the Beck Depression Inventory and the State-Trait Anxiety Inventory additionally.ResultsPatients treated for non-secreting intra- and parasellar tumors go to bed earlier, fall asleep earlier, need less time to prepare to sleep but also to get up. Additionally, they lie and sleep longer. The subgroup analysis showed that patients with secondary adrenal insufficiency compared to controls experienced shorter daily light exposure and longer sleep latency. Higher hydrocortisone dose (>20mg) was associated with worse score in global, physical and mental health, shorter time to prepare to sleep, earlier sleep onset and longer sleep duration.ConclusionOur study shows that patients treated for non-secreting intra- and parasellar tumors, even if successfully treated, experience altered sleep patterns compared to controls. We suggest that managing clinicians should enlighten these possible sleep alterations to their patients and use specific questionnaires to document sleep disturbances. Additionally, when treating patients surgically, especially by transcranial approach, damaging the suprachiasmatic nucleus should be avoided. Furthermore, circadian hydrocortisone replacement therapy ideally with dual-release hydrocortisone - if possible, in a dose not more than 20mg daily - that resembles physiological cortisol levels more closely may be beneficial and could improve sleep patterns and sleep-related quality of life.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Sleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study

et al. 2022

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“…We may need to improve patients' overall health to enhance their QoL. Previous studies have shown that appropriate postoperative cognitivebehavioral treatment and sustained drug therapy are helpful in improving health (Wild et al, 2020). A combination of these two treatments may be worth considering in the rehabilitation of patients.…”

Section: Discussionmentioning

confidence: 99%

Variables Associated With Body Image Concerns in Acromegaly Patients: A Cross-Sectional Study

Zhang

Zhong

et al. 2022

Front. Psychol.

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ObjectiveAcromegaly is often characterized by altered physical (including facial) appearance. However, there is little medical or psychological research on body image concerns in patients with acromegaly. The aim of this study was to identify factors influencing the body image distress in patients with acromegaly and to explore the possible effects of stigma on body image concerns.DesignCross-sectional study.MethodsA total of 68 individuals with acromegaly were enrolled in the study. A total of 70 persons with nonfunctional pituitary adenomas were randomly recruited as a healthy control group. Using structured questionnaires, we explored perceived body image using the Body Image Concern Inventory. We also used the Hamilton Anxiety Scale, the Stigma Scale for Chronic Illness, the Brief Illness Perception Questionnaire, and the 36-Item Short-Form Health Survey to evaluate health-associated variables and to analyze factors that affect body image concerns in patients with acromegaly.ResultsOf the 68 participants, 31 were men and 37 women (mean age ± standard deviation: 46.36 ± 12.47 years). The mean body image concern score was 47.49 ± 13.81 for patients with acromegaly and 21.10 ± 7.44 for patients with nonfunctional pituitary adenoma. The difference between the two groups was statistically significant. A multiple stepwise regression analysis showed that the related factors for body image distress were gender (P = 0.001), age at diagnosis (P = 0.01), and internalized stigma (P < 0.001, Adj. R2 = 0.756).ConclusionsPeople with acromegaly have substantial body image concerns, and these concerns are increased by the stigma associated with this disease; such concerns lead to poor quality of life (QoL). Physicians need to find better ways to control patients' hormone levels, and nurses should provide more information on how to improve body image or find ways to reduce patients' body image distress.

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“…In recent years, concern about celiac patients' QoL has increased [22][23][24][25][26][27] and to measure the impact of the difficulties faced by individuals with CD on their QoL, an instrument was developed and validated, considering the specificities linked to the experience and management of CD [8]. The Celiac Disease Quality of Life Questionnaire (CDQ) is a quantitative, self-administered questionnaire comprising 28 questions to evaluate QoL in CD individuals that consider symptoms, diet, social exclusion, and concerns experienced by celiac patients [11].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life Perception among Portuguese Celiac Patients: A Cross-Sectional Study Using the Celiac Disease Questionnaire (CDQ)

et al. 2023

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The aim of this study is to assess Portuguese celiac patients’ quality of life (QoL) perception. A cross-sectional study was performed with a non-probability convenience sample of Portuguese celiac patients using an online self-administered celiac disease quality of life questionnaire (CDQ), previously validated for the Portuguese population. The final sample comprised 234 celiac patients, which included the following: primarily women (69.2%); aged between 18 and 49 years old (56.4%); with a partner (60.6%); with a high educational level (58.9%—graduated or post-graduated); following a gluten-free diet (GFD) (55.1%); and not using antidepressants (93.1%). The Portuguese CDQ presented good reliability and responsiveness in this sample of Portuguese celiac patients. In general, the CDQ in Portugal was affected by age at diagnosis (p = 0.017), educational level (p = 0.005), and compliance with GFD (p = 0.034). The emotion domain was affected only by using antidepressants (p = 0.036). The social domain was affected by gender (females had lower rates, p = 0.016), age at diagnosis (p = 0.009), educational level (p = 0.000), and compliance with a GFD (p = 0.002). The worries domain did not differ according to socioeconomic data. The symptoms domain was affected by compliance with GFD (p = 0.000), age at diagnosis (p = 0.000), and educational level (p = 0.014). Data on celiac QoL is essential to support the formulation and implementation of strategies to minimize the issues suffered by celiac patients, lowering their physical, emotional, and social burden. Additionally, data on Portuguese celiac disease patients using the CDQ will allow future comparative research among celiac populations from different countries.

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Health-related quality of life in patients with non-functioning pituitary adenoma: a special focus on hydrocortisone replacement dose

Cited by 8 publications

References 30 publications

Sleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study

Sleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study

Variables Associated With Body Image Concerns in Acromegaly Patients: A Cross-Sectional Study

Quality of Life Perception among Portuguese Celiac Patients: A Cross-Sectional Study Using the Celiac Disease Questionnaire (CDQ)

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