Health‐related quality of life in patients with bronchiolitis obliterans

Abstract

Introduction Bronchiolitis obliterans (BO) is mainly caused by infections and hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the health‐related quality of life (HRQOL) of children with BO compared to the healthy children and also to assess the HRQOL according to the etiology. Methods Postinfectious (group 1) and post‐HSCT BO (group 2) patients and healthy children were included in the study. HRQOL was assessed by the Short Form‐36 (SF‐36) and St George's Respiratory Questionnaire (SGRQ). Correlations between demographic and clinical characteristics, pulmonary function tests, high‐resolution chest tomography scores, and HRQOL were assessed. Results Thirty‐seven postinfectious and post‐HSCT BO patients and 34 healthy children were included in the study. Mean age was 13.8 ± 0.7 years. Mean forced vital capacity and forced expiratory volume1 were 60.7 ± 2.7% predicted, and 49.8 ± 3.1% predicted, respectively. The SF‐36 scores were lower in BO patients compared to healthy children (P < .01). Patients with better lung functions had higher SF‐36 scores, but lower SGRQ. The number of inhaled therapies, acute exacerbations, hospitalizations were inversely correlated with SF‐36. A positive correlation was found between these parameters and total SGRQ scores (r = .507, P = .02; r = .409, P = .12; r = .326, P = .049, respectively). SF‐36 scores were better in group 1 for subscales of physical role functioning and social role functioning compared to group 2. (P = .01, P = .01, respectively). Conclusion The HRQOL of patients with BO measured by SF‐36 was low compared to healthy children. SF‐36 scores were more affected in post‐HSCT BO patients. HRQOL of children with chronic lung disease should be taken into consideration in the management of these patients.

Analysis of Risk Factors of Bronchiolitis Obliterans in Children with Mycoplasma pneumoniae Bronchiolitis

“…To a certain extent, it can reflect the clinical severity of the disease, and it is also one of the indicators to predict the prognosis of patients with community-acquired pneumonia [ 24 , 25 ]. This study suggests that higher levels of serum LDH are related to the increased risk of BO in children with MP bronchiolitis, which is consistent with the findings of Atag et al [ 10 ] that serum LDH level is an independent risk factor for BO in MP pneumonia.…”

“…BO after MP infection is mostly secondary to acute bronchiolitis [ 7 , 9 ]. However, there are few studies on the incidence and risk factors of BO after MP bronchiolitis, partly due to the limited number of patients [ 10 ]. With the increase of BO in children with MP bronchiolitis, most of the children with BO are characterized by recurrent cough and asthma, poor exercise endurance, recurrent respiratory tract infection, and impaired lung function.…”

Parent's report on oral health‐related quality of life of children with cystic fibrosis

“…22,23 A recent study showed that a decreased FEV1pp causes a deterioration in the HRQoL. 24 Bodnar et al…”

“…HRQoL scales are now widely used in cwCF which reflects the course of the disease 22,23 . A recent study showed that a decreased FEV1pp causes a deterioration in the HRQoL 24 . Bodnar et al suggested that malnutrition, hospitalization rate, and PA colonization were the most significant factors to have a huge negative impact on the HRQoL of CF patients 3 …”

Pediatric pulmonology 2020 year in review: Rare and diffuse lung disease

“…Three important manuscripts on bronchiolitis obliterans among children post‐HSCT provided data on quality of life measures, pulmonary function trends, and new treatments. Atag et al 30 compared health‐related quality of life in 37 children with BO (19 post‐infectious and 18 post‐HSCT) to 34 matched healthy controls using two validated instruments for measuring physical and emotional health. Patients with BO had lower scores compared with controls, and scores were lowest in the post‐HSCT group.…”