Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I

Zhou, Yang; Irwin, Melinda L.; Ferrucci, Leah M.; McCorkle, Ruth; Ercolano, Elizabeth; Li, Fangyong; Stein, Kevin; Cartmel, Brenda

doi:10.1016/j.ygyno.2016.04.006

Cited by 40 publications

(34 citation statements)

References 39 publications

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“…Most research on cancer survivorship has been conducted in high-income settings where patients were more likely to receive a timely diagnosis, optimal treatment, follow-up, and survivorship care. Survival rates, therefore, differ drastically between countries but, regardless of setting, many cancer survivors experience symptom burden, loss of HRQoL, and (at least mild) psychological distress in the first year after treatment [12, 13, 36, 37]. Cancer stage is widely recognized as an important clinical determinant of HRQoL in cancer survivors [12, 19, 37–42].…”

Section: Discussionmentioning

confidence: 99%

“…Survival rates, therefore, differ drastically between countries but, regardless of setting, many cancer survivors experience symptom burden, loss of HRQoL, and (at least mild) psychological distress in the first year after treatment [12, 13, 36, 37]. Cancer stage is widely recognized as an important clinical determinant of HRQoL in cancer survivors [12, 19, 37–42]. A diagnosis of lung cancer and having comorbid conditions are also associated with a high symptom burden and low HRQoL [12, 13, 36, 37].…”

Section: Discussionmentioning

confidence: 99%

“…Cancer stage is widely recognized as an important clinical determinant of HRQoL in cancer survivors [12, 19, 37–42]. A diagnosis of lung cancer and having comorbid conditions are also associated with a high symptom burden and low HRQoL [12, 13, 36, 37]. In both low- and high-income settings, socioeconomic disparity in cancer survivors has been associated with poor HRQoL [12, 13, 35, 42–45] and psychological distress [46, 47].…”

Section: Discussionmentioning

confidence: 99%

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Health-related quality of life and psychological distress among cancer survivors in Southeast Asia: results from a longitudinal study in eight low- and middle-income countries

Kimman

Jan

Peters

et al. 2017

BMC Med

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BackgroundA better understanding of health-related quality of life (HRQoL) and psychological distress in cancer survivors can raise awareness, promote the development of policies in cancer survivorship care, and facilitate better targeted use of limited resources in low- and middle-income countries (LMICs). The main objectives of this paper were therefore to assess HRQoL and the prevalence of psychological distress amongst cancer survivors in Southeast Asia and identify risk factors of these outcomes.MethodsThe ACTION study was a longitudinal study in eight LMICs in Southeast Asia with 5249 first time cancer survivors followed up at 1 year after diagnosis. HRQoL was assessed using the EORTC QLQ-C30 and EQ-5D. Psychological distress (anxiety and depression) was assessed using the Hospital Anxiety and Depression Scale. General linear models and multiple logistic regression were used to identify independent predictors of HRQoL and psychological distress.ResultsOne year after diagnosis, the mean EORTC QLQ-C30 global health score for survivors was 66.2 out of 100 (SD 22.0), the mean index score on the EQ-5D was 0.74 (SD 0.23), 37% of survivors had at least mild levels of anxiety, and 46% showed at least mild levels of depression. Poorest HRQoL and highest prevalence of anxiety and depression were seen in patients with lung cancer and lymphomas, while highest scores and least psychological distress were seen in female patients with breast and cervical cancer. The most significant predictor of poor HRQoL and psychological distress outcomes was cancer stage at diagnosis. Age, co-morbidities, treatment, and several socioeconomic factors were associated with HRQoL and psychological distress.ConclusionsCancer survivors in LMICs in Southeast Asia have impaired HRQoL and substantial proportions have psychological distress. Patients with advanced cancer stages at diagnosis and those in a poor socioeconomic position were most at risk of such poor outcomes. Supportive interventions for cancer patients that address wider aspects of patient wellbeing are needed, as well as policies that address financial and other barriers to timely treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-016-0768-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Health-related quality of life and psychological distress among cancer survivors in Southeast Asia: results from a longitudinal study in eight low- and middle-income countries

Kimman

Jan

Peters

et al. 2017

BMC Med

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“…Moreover, all these aspects are prone to substantial variability, which may also be related to the instruments used for its evaluation. In a study from 2016 in women surviving ovarian cancer for at least 1 year, lower health-related QoL was associated with disease recurrence, treatment status, symptom burden, age, and number of comorbidities 21. A recent review noted that ovarian cancer survivors experience a wide range of sequelae that may persist for a lengthy time and negatively impact QoL 22…”

Section: Discussionmentioning

confidence: 99%

Impact of Recurrence of Ovarian Cancer on Quality of Life and Outlook for the Future

Colombo

Lorusso

Scollo

2017

Int J Gynecol Cancer

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ObjectiveOvarian cancer recurs in most patients, with a 5-year survival rate less than 30%. Quality of life is an increasingly important issue in patients with cancer, but there are limited data in women with recurrent ovarian cancer in this regard.Materials and MethodsWe used an ad hoc questionnaire to compare changes in health perceptions, burden of disease, and expectations for the future quality of life in women with and without recurrence of ovarian cancer. A total of 173 women were included, 116 with relapse and 57 without, undergoing follow-up in a routine clinical setting.ResultsSubstantial differences were seen in self-assessed health status between women with and without recurrence; 33.6% and 82.4% of women with and without recurrence rated their health as good to excellent, respectively. More patients with recurrence of disease reported limitations in moderate activity than those without. Furthermore, 79.0% of women without recurrence reported that pain did not affect or only slightly affected daily activities, compared with 28.2% with recurrence. Most women with recurrence (59.5%) reported that they were able to do less than they wanted to because of their emotional status compared with only 15.8% of women without recurrence. In addition, 66.4% of women with recurrence referred that they had problems concentrating at work and home versus 26.3% of women without recurrence.ConclusionsFrom this survey, it is clear that relapse of disease has a negative psychological and physical impact, highlighting the importance of time without recurrence and the need for effective treatment in the long term.

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“…Factors such as disease stage at diagnosis and disease recurrence have been shown to impact QOL [20–22]. However, evidence is mixed with some studies showing no association between clinical factors and QOL [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach

Gonzalez

Manne

Stapleton

et al. 2016

Support Care Cancer

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Purpose The course of quality of life after diagnosis of gynecologic cancer is not well understood. We aimed to identify subgroups of gynecologic cancer patients with distinct trajectories of quality of life outcomes in the 18-month period after diagnosis. We also aimed to determine whether these subgroups could be distinguished by predictors derived from Social-Cognitive Processing Theory. Methods Gynecologic cancer patients randomized to usual care as part of a psychological intervention trial (NCT01951807) reported on depressed mood, quality of life, and physical impairment soon after diagnosis and at five additional assessments ending 18 months after baseline. Clinical, demographic, and psychosocial predictors were assessed at baseline, and additional clinical factors were assessed between 6–18 months after baseline. Results A two-group growth mixture model provided the best and most interpretable fit to the data for all three outcomes. One class revealed subclinical and improving scores for mood, quality of life, and physical function across 18 months. A second class represented approximately 12% of patients with persisting depression, diminished quality of life, and greater physical disability. Membership of this high-risk subgroup was associated with holding back concerns, more intrusive thoughts, and use of pain medications at the baseline assessment (ps < .05). Conclusions Trajectories of quality of life outcomes were identified in the 18-month period after diagnosis of gynecologic cancer. Potentially modifiable psychosocial risk factors were identified that can have implications for preventing quality of life disruptions and treating impaired quality of life in future research.

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Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I

Cited by 40 publications

References 39 publications

Health-related quality of life and psychological distress among cancer survivors in Southeast Asia: results from a longitudinal study in eight low- and middle-income countries

Health-related quality of life and psychological distress among cancer survivors in Southeast Asia: results from a longitudinal study in eight low- and middle-income countries

Impact of Recurrence of Ovarian Cancer on Quality of Life and Outlook for the Future

Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach

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