Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation

Witassek, Fabienne; Springer, Anne; Adam, Luise; Aeschbacher, Stefanie; Beer, Jürg H.; Blum, Steffen; Bonati, Leo H.; Conen, David; Kobza, Richard; Kühne, Michael; Moschovitis, Giorgio; Oßwald, Stefan; Rodondi, Nicolas; Sticherling, Christian; Szucs, Thomas D.; Schwenkglenks, Matthias

doi:10.1371/journal.pone.0226730

Cited by 42 publications

(34 citation statements)

References 33 publications

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“…26 In the study by Wojaszel et al, AF was related to significantly higher scores of FS, independently from age, gender, multimorbidity, and polypharmacy. 31 In our study, the regression analysis identified FS as a statistically significant independent predictor of increased arrhythmia symptom severity in ASTA II and decreased QoL in ASTA III. The issue of QoL is now often addressed in medicine.…”

Section: Discussionsupporting

confidence: 51%

<p>Quality of Life and Frailty Syndrome in Patients with Atrial Fibrillation</p>

Sławuta¹,

Polański²,

Mazur³

et al. 2020

CIA

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Introduction: Atrial fibrillation (AF) and frailty syndrome (FS) are a part of the aging process. Both are still of great importance in the assessment of quality of life (QoL). There is definitely a lack of research clarifying the association between FS and QoL in AF patients. Objective: The aim of this study was to evaluate the influence of FS on QoL in AF patients. Materials and Methods: The retrospective and observational study included 158 inpatients with mean age 69.8±7.1 years, treated for AF in the cardiac department from 1 April 2019 to 31 June 2019. The following instruments were used: the Arrhythmia-Specific Questionnaire in Tachycardia and Arrhythmia (ASTA) and the Edmonton Frail Scale (EFS). Results: The mean level of frailty in the study group was 8.5±5.0. In 25.9% of patients, the level of frailty was mild, in 10.1% moderate, and in 17.1% severe. Patients were divided into two groups based on their frailty status. In comparative analysis of the QoL, there were significant differences between the groups: the frail group had more intense symptoms of arrhythmia than the non-frail group (14.9±4.1 vs 11.9±4.9; p<0.001). In the analysis of the total score impact of arrhythmia on QoL, the frail group had a significantly higher score than the non-frail group (23.5±5.2 vs 14.5±5.5), which confirmed the stronger negative impact of arrhythmia on QoL. In the regression coefficient analysis, the independent predictor of symptom severity and QoL was FS. However, we observed a negative impact of diabetes, which increased the impact of arrhythmia on QoL, and physical activity, which improved QoL and decreased the impact of symptoms on everyday life. Conclusion: Patients in the frail group have worse QoL and higher impact of arrhythmia on QoL in comparison to patients in the non-frail group. Frailty is an independent predictor of higher intensity of symptoms of arrhythmia and worse QoL. Diabetes and physical activity are predictors of QoL for patients with AF.

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Section: Discussionsupporting

confidence: 51%

<p>Quality of Life and Frailty Syndrome in Patients with Atrial Fibrillation</p>

Sławuta¹,

Polański²,

Mazur³

et al. 2020

CIA

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“… 7 The EHRA score is considered one of the strongest predictors of QoL, regardless of the type of AF, and is commonly used to assess improvement in symptoms after treatment of AF. 8 …”

Section: Introductionmentioning

confidence: 99%

Improvement in Atrial Fibrillation-Related Symptoms After Cardioversion: Role of NYHA Functional Class and Maintenance of Sinus Rhythm

Ferré-Vallverdú

Ligero

Vidal-Pérez

et al. 2021

CIA

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Background The European Heart Rhythm Association (EHRA) score is a proven and validated tool for assessing the symptoms of atrial fibrillation (AF). Little is known about the variables related to this score and how it changes after cardioversion. Methods We analyzed 744 patients undergoing elective cardioversion in whom AF-related symptoms were assessed at baseline and after 6 months of follow-up using the EHRA score. We assessed the association between the EHRA score and other clinical and echocardiographic variables at baseline and after 6 months of follow-up. Results At 6 months of follow-up, we observed a reduction in the EHRA score in 50% and worsening in 2.8% of patients who remained in sinus rhythm (SR) compared with 34.6% and 11.3%, respectively, of patients with AF episodes (p<0.0001). Patients who maintained SR at 6 months were less symptomatic than those with AF (EHRA score 1.13 ± 0.35 vs 1.42 ± 0.59; p<0.0001). The independent predictors for reduction in the EHRA score after cardioversion were NYHA ≥II at baseline and maintenance of SR (p<0.0001). Conclusion The greatest improvement in AF-related symptoms was in patients who remained in SR at 6 months after cardioversion and in patients with worse NYHA functional class at baseline.

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“…The majority of published studies on QoL in AF relate to the response to rhythm control therapies such as antiarrhythmic drugs or ablation. In contrast, patients with permanent AF have even worse QoL [6], account for around 50% of all patients, and yet we lack an adequate description of underlying factors [7].…”

Section: Introductionmentioning

confidence: 99%

Importance and Assessment of Quality of Life in Symptomatic Permanent Atrial Fibrillation: Patient Focus Groups from the RATE-AF Trial

Jones¹,

Stanbury²,

Haynes³

et al. 2020

Cardiology

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Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation

Cited by 42 publications

References 33 publications

<p>Quality of Life and Frailty Syndrome in Patients with Atrial Fibrillation</p>

<p>Quality of Life and Frailty Syndrome in Patients with Atrial Fibrillation</p>

Improvement in Atrial Fibrillation-Related Symptoms After Cardioversion: Role of NYHA Functional Class and Maintenance of Sinus Rhythm

Importance and Assessment of Quality of Life in Symptomatic Permanent Atrial Fibrillation: Patient Focus Groups from the RATE-AF Trial

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