Health-related quality of life in patients with systemic lupus erythematosus and its relationship with cyclophosphamide pulse therapy

Medeiros, Marta Maria; Menezes, Ana Paula T.; Silveira, Virgínia Angélica Lopes; Ferreira, Fernanda Nogueira Holanda; Lima, George Rafael Martins de; Ciconelli, Rozana Mesquita

doi:10.1016/j.ejim.2007.06.012

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…These findings were in agreement with a study done by Cho et al 33 and Medeiros et al 34 , they found that there was no significant difference in HRQoL between SLE patients with and without renal involvement.…”

Section: Resultssupporting

confidence: 93%

Quality of Life and It's Relation to Disease Activity in Egyptian Patients with Systemic Lupus Erythematosus

Shahba¹,

Kabbash²

2015

Egypt J of Rheumatol & Clinical Immunol

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Objective: The aim of the present work is to study the effect of Systemic Lupus Erythematosus( SLE) and its activity on the quality of life in SLE patients. Subjects and Methods: In this study, we investigated One Hundred SLE patients as regards disease activity and its impact on the quality of life (QoL). Disease activity was measured by SLE Disease Activity Index (SLEDAI), and quality of life was measured by Short Form-36 health questionnaire (SF-36). Results: Mucocutaneous, hematological and renal manifestations were present in most of the patients and arthritis in 20% . Participants with mild to moderate activity represented 47% of the SLE population in our study and 25% had severe activity. No activity was present in 28%. All domains of SF-36 were found lower in SLE patients with correlation of some domains with disease activity measured by SLEDI. This correlation was found significant with physical functioning component, role limitation due to physical health and role limitation due to emotional problems and pain. Conclusion: Physical and emotional domains of QoL are impaired to a larger extent in active lupus. However, social, environmental QoL don't correlate with the disease activity status in lupus patients. These findings may provide useful information to improve our understanding and provide better support to SLE patients beside rapid meticulous control of disease activity. [Egypt J Rheumatology & Clinical Immunology, 2015; 3(2): 95-103]

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Section: Resultssupporting

confidence: 93%

Quality of Life and It's Relation to Disease Activity in Egyptian Patients with Systemic Lupus Erythematosus

Shahba¹,

Kabbash²

2015

Egypt J of Rheumatol & Clinical Immunol

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“…In this study, cyclophosphamide pulse therapy did not worsen HRQoL; rather, psychological distress was the main explanatory variable of poor HRQoL in these patients [23].…”

Section: Pharmacologic Studies and Health-related Quality Of Lifementioning

confidence: 46%

Treatment of Lupus: Impact on Quality of Life

Toloza¹,

Sequeira

Jolly

2011

Curr Rheumatol Rep

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Systemic lupus erythematosus (SLE) is an autoimmune disease that disproportionately affects women of childbearing age during their most productive years. Current therapeutic measures have improved patient survival; however, the impact of interventions on general and specific domains of health-related quality of life requires further study. Medical Outcomes Survey Short Form 36 (SF-36), the most commonly used measure, has been included in some SLE randomized controlled trials, but the observed effect sizes were generally small and in some cases negligible. An SLE patient's quality of life is known to be significantly worse than that of someone in the general population and perhaps worse than those with most other common chronic diseases. SF-36, although useful as a general measure, may not be the most sensitive way to gauge changes perceived by patients with SLE. Ongoing trials and observational longitudinal studies using lupus-specific health-related quality-of-life measures may help better determine health-related quality-of-life responses and determine the domains most amenable to interventions.

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“…Even though in cross-sectional studies, poor correlation may be noted Similarly, the effect of cyclophosphamide pulse therapy on HRQoL was examined in a Brazilian study that compared cyclophosphamide users with nonusers to ascertain treatment burden. In this study, cyclophosphamide pulse therapy did not worsen HRQoL; rather, psychological distress was the main explanatory variable of poor HRQoL in these patients [49].…”

Section: Validated Sle-specific Measuresmentioning

confidence: 46%

Quality-of-Life Measurements in Multiethnic Patients with Systemic Lupus Erythematosus: Cross-Cultural Issues

Toloza¹,

Jolly

Alarcón

2010

Curr Rheumatol Rep

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Although the survival rate for systemic lupus erythematosus (SLE) has improved dramatically during the past 50 years, the quality of life of patients afflicted with this disease remains poor. Currently existent measures of disease activity and damage in SLE do not capture the patient's perspective and health-related quality of life (HRQoL). Most studies in SLE pertaining to HRQoL are from developed Western societies, with only a few from others. These studies have been conducted predominantly in women and using the Medical Outcomes Survey Short Form 36, a generic HRQoL instrument that has been shown not to be sensitive to change in lupus. Existent lupus-specific HRQoL measures have not yet been used in SLE clinical trials. New HRQoL research tools are currently undergoing validation in different countries, languages, and cultural settings, which may help dissect the underlying role of socioeconomic status and specific disease-related features that impact SLE-related quality of life.

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Health-related quality of life in patients with systemic lupus erythematosus and its relationship with cyclophosphamide pulse therapy

Cited by 12 publications

References 18 publications

Quality of Life and It's Relation to Disease Activity in Egyptian Patients with Systemic Lupus Erythematosus

Quality of Life and It's Relation to Disease Activity in Egyptian Patients with Systemic Lupus Erythematosus

Treatment of Lupus: Impact on Quality of Life

Quality-of-Life Measurements in Multiethnic Patients with Systemic Lupus Erythematosus: Cross-Cultural Issues

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