Health-Related Quality of Life in Patients with Chronic Hepati-tis B: A Meta-Analysis of Observational Studies

Abstract

Background: Chronic hepatitis B virus (CHB) infection is one of the most common liver infections worldwide. Approximately 240 million patients are diagnosed with CHB. The objective of this meta-analysis was to identify the effect of CHB on the affected patients’ health-related quality of life and compare with the control group.
 Methods: A comprehensive search was conducted through PubMed, Medline, ProQuest, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Web of Science databases up to Jul 2022.
 Results: Five primary observational studies using SF-36 and WHOQOL surveys with 1135 participants (646 with CHB and 489 healthy individuals) included in the meta-analysis. We evaluated the scores of physical and mental component summaries. HRQoL was comparable in both groups. The disease's impact appears to slightly affect the mental component summary than the physical component summary.
 Conclusion: The HRQoL in CHB patients is mainly reflected in the impairment of the mental aspect. It is vital to focus on optimally managing care, family and social support, stress management.

Therapeutic effectiveness analysis of tenofovir alafenamide and tenofovir disoproxil fumarate on the treatment for chronic hepatitis B

“…As the condition worsens, it can lead to serious complications such as liver cirrhosis and liver cancer, which can endanger the patient's life. [1][2][3] It is reported that HBV infection is a global epidemic, and in recent years, with the influence of factors such as work and lifestyle habits, the incidence of HBV infection has continued to rise. If the disease is not controlled in a timely manner, it can be transmitted through blood, body fluids, and mother-to-child transmission.…”