Health‐related quality of life in patients with chronic hepatitis B

Bondini, Silvia; Kallman, Jillian; Dan, Adrian G.; Younoszai, Zahra; Ramsey, Lolita; Nader, Fatema; Younossi, Zobair M.

doi:10.1111/j.1478-3231.2007.01558.x

Cited by 74 publications

(73 citation statements)

References 38 publications

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“…Our results differ from literature data [14]. According to the most relevant studies, generic QoL score (mainly assessed by SF-36 questionnaire) was significantly lower within the patients with CLD compared with healthy controls, including the studies of Bondini et al [20], which indicate significantly lower SF-36 scores in patients with cholestatic liver diseases and viral hepatitis C in comparison with the control group. The study of Younossi et al [21] pointed out that the SF36 scores were significantly lower in the group of patients with CLD regardless of the etiology, compared with healthy subjects.…”

Section: Discussioncontrasting

confidence: 57%

“…Ranking within groups is presented in Table 1. 3,6,21,23,27), the activity (3 questions; the order of 7, 9, 14), emotional functioning (8 questions; the order of 10,12,15,16,19,20,24,26), as well as concerns (5 questions; the order of 18,22,25,28,29). The average score for each domain is equal to the sum of ranks for all issues related to this area, divided by the number of questions.…”

Section: Methodsmentioning

confidence: 99%

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A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

Obradović

Gluvić

Petrović

et al. 2017

Romanian Journal of Internal Medicine

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Introduction. Chronic liver diseases (CLD) are an important cause of morbidity and mortality in general population. The aim of this study was to analyze potential differences between patients with CLD and healthy control group, and to estimate the severity of CLD by using simple questionnaires: general health questionnaire (GHQ-12) and chronic liver disease questionnaire (CLDQ).Methods. A cross-sectional pilot study was performed in Zemun Clinical Hospital during years 2014 and 2015. Sixty participants were divided into 4 groups (15 per group): chronic alcoholic hepatitis, other chronic hepatitis, liver cirrhosis, and healthy control group. Entire study population chose one of four offered answers of structured questionnaires GHQ-12 and CLDQ, based on which mean model of end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores were calculated.Results. Mean GHQ12 and CLDQ scores were 10.5 and 5.21 ± 1.11 respectively. Regarding certain CLDQ domain scores, a significant difference between alcoholic and non-alcoholic hepatitis groups in the worry domain was observed. Mean MELD score was 7.42 ± 2.89 and did not differ between chronic hepatitis groups, while mean CTP score was 5.73 ± 0.88. A statistically significant correlation was observed between GHQ12 and CLDQ scores (ρ = -0.404, p < 0.01), but not between subjective and objective scores.Conclusions. Mean GHQ12 and CLDQ scores pointed out to general psychological no-distress condition of the studied participants, as well as scarcely expressed CLD-specific complaints. Mean MELD and CTP scores indicated stable chronic liver diseases, with low three-month mortality rates in the cases of chronic hepatitis, as well as determination to Child A group in the case of liver cirrhosis.

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Section: Discussioncontrasting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

Obradović

Gluvić

Petrović

et al. 2017

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

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“…Strengths of the study include its large size and high response rate, and also use of an instrument that has been extensively validated in diverse populations of healthy and chronically ill individuals (17,25,(33)(34)(35). This report includes a greater number of respondents and a higher response rate than any other available report of HRQOL following RRT in the literature.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Health Utility among 60-Day Survivors of Acute Kidney Injury in the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study

Johansen

Smith²,

Unruh³

et al. 2010

Clinical Journal of the American Society of Nephrology

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Background and objectives: Health-related quality of life (HRQOL) after acute kidney injury (AKI) is an area of great importance to patients. It was hypothesized that HRQOL after AKI would relate to intensity of dialysis during AKI and dialysis dependence at follow-up.Design, setting, participants, & measurements: The Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study was a multicenter, prospective, randomized trial of intensive versus less intensive renal replacement therapy in critically ill patients with AKI. Of 1124 participants, 415 survived at least 60 days and completed the Health Utilities Index (HUI), which measures 8 health attributes and calculates an overall HRQOL score, also called a utility score. How strongly pre-intensive care unit (ICU) health, severity of illness, hospital course, intensity of dialysis, and outcome were associated with 60-day HUI scores was assessed, after adjustment for demographics.Results: The overall HUI score was 0.40 ؎ 0.37, indicating severely compromised health utility and was associated with only admission from home and hospital and ICU length of stay (LOS). Ambulation was better among those with a shorter hospital and ICU LOS. Better cognition was associated with dialysis independence and with fewer comorbid chronic illnesses. Emotion was associated with only hospital LOS. Pain was associated with ICU LOS.Conclusions: Health utility was low in this cohort of patients after AKI, and intensity of dialysis did not affect subsequent health utility. The effects of a lengthy hospitalization generally outweighed the effects of delayed recovery of kidney function on HRQOL after AKI.

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“…Those who died during the course of the study were assigned an HUI3 score of 0 at the cycle of their death and censored thereafter. There is substantial evidence on the construct validity of HUI3 in population health and clinical studies, including studies of people with chronic conditions that are associated with alcohol consumption (liver disease, type 2 diabetes, dementia, impaired mental health, and heart disease) (Asakawa et al, 2008;Bondini et al, 2007;Feeny et al, 2009Feeny et al, , 2012Fisk et al, 2005;Garster et al, 2009;Grootendorst et al, 2000;Jones et al, 2005;Kavirajan et al, 2009;Maddigan et al, 2004Maddigan et al, , 2006Marra et al, 2005;Revicki et al, 2008;Wilkins, 2006;Younossi et al, 2001), and the scoring procedures can be found elsewhere (Feeny et al, 2002. Differences (or changes) of .03 or more in the overall HUI3 score are important clinically (Drummond, 2001;Grootendorst et al, 2000;Horsman et al, 2003).…”

Section: Methodsmentioning

confidence: 99%

Alcohol Use Patterns and Trajectories of Health-Related Quality of Life in Middle-Aged and Older Adults: A 14- Year Population-Based Study

Kaplan

Huguet

Feeny

et al. 2012

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: A 14-year multiwave panel design was used to examine relationships between longitudinal alcohol-consumption patterns, especially persistent moderate use, and change in health-related quality of life among middle-aged and older adults. Method: A nationally representative sample of 5,404 community-dwelling Canadians ages 50 and older at baseline (1994/1995) was obtained from the longitudinal National Population Health Survey. Alcohol-consumption patterns were developed based on the quantity and frequency of use in the 12 months before the interview. Health-related quality of life was assessed with the Health Utilities Index Mark 3 (HUI3). Latent growth curve modeling was used to estimate the change in HUI3 for each alcohol pattern after adjusting for covariates measured at baseline. Results: Most participants showed stable alcohol-consumption patterns over 6 years. Persistent nonusers, persistent former users, those decreasing their consumption levels, and those with unstable patterns (i.e., U shaped and inverted U shaped) had lower HUI3 scores at baseline compared with persistent moderate drinkers. A more rapid decline in HUI3 scores than that observed for persistent moderate users was seen only in those with decreasing consumption (p < .001). In a subgroup identifi ed as consistently healthy before follow-up, longitudinal drinking patterns were associated with initial HUI3 scores but not rates of change. Conclusions: Persistent moderate drinkers had higher initial levels of health-related quality of life than persistent nonusers, persistent former users, decreasing users, U-shaped users, and inverted U-shaped users. However, rates of decline over time were similar for all groups except those decreasing their consumption, who had a greater decline in their level of health-related quality of life than persistent moderate users. (J. Stud. Alcohol Drugs, 73, 581-590, 2012)

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Health‐related quality of life in patients with chronic hepatitis B

Abstract: CH-B patients have better HRQL than CH-C, PBC and population norms. CH-B patients' overall utility scores are lower than population norms.

Cited by 74 publications

References 38 publications

A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

Predictors of Health Utility among 60-Day Survivors of Acute Kidney Injury in the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study

Alcohol Use Patterns and Trajectories of Health-Related Quality of Life in Middle-Aged and Older Adults: A 14- Year Population-Based Study

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