“…Studies assessing correlates of depression and anxiety have provided inconsistent results regarding gender, age, marital status, educational level, severity and subset (limited or diffuse SSc) of the disease and organ involvement. They have, however, an established relationship with pain [6,7], functional status [5,8] and fatigue [6,9], because patients with worse functional status, or experiencing higher levels of pain or fatigue, tend to report more symptoms of anxiety and depression. Moreover, depression and anxiety are associated with impaired quality of life [5,10].…”