Hemodialysis vascular access profoundly impacts the quality of care for chronic kidney disease (CKD) patients worldwide, with arteriovenous fistulas (AVFs) preferred for superior outcomes. Despite global guidelines, Sub-Saharan Africa, including Tanzania, faces challenges, by still relying on non-tunneled central venous catheters (CVCs) due to accessibility and financial constraints. We aimed to describe the pattern of vascular access use among CKD patients on maintenance hemodialysis at Muhimbili National Hospital. A cross‑sectional study to describe the pattern of vascular access among patients with CKD on maintenance hemodialysis therapy. Descriptive statistics were used to summarize the baseline characteristics and patterns of vascular access. Our study received ethical clearance from the Muhimbili National Hospital Research Ethics Committee (Ref: MNH/IRB/VOL.1/2024/005). All consent forms were written and provided in English or Swahili. We analysed 200 study participants, with a mean age of 53.3 (14.5) years. Almost all participants initiated hemodialysis with nontunneled central venous catheters (95.5%). A substantial portion continued to use non-tunneled CVCs (25.5%) with mean duration of 7.1 (2.1) months, some transitioning to tunneled CVCs (39.5%) or AVFs (35%). Among patients with multiple nontunneled catheters, catheter dislodgement was the main indication for catheter replacement. Our study highlights the prevalent use of nontunneled central venous catheters (CVCs) as the primary vascular access method for CKD patients undergoing hemodialysis at Muhimbili National Hospital, Tanzania. These findings underscore the urgent need for analysis of the cost associated with non-tunneled catheter reliance and interventions to improve access to AVFs and enhance vascular access management, ultimately optimizing patient outcomes in resource-limited settings.