Health‐related quality of life using intensity‐modulated radiation therapy for post‐prostatectomy radiotherapy

Gysen, Kirsten L van; Kneebone, Andrew; Guo, Linxin; Vaux, Kenneth J.; Lazzaro, E.; Eade, Thomas

doi:10.1111/j.1754-9485.2012.02464.x

Cited by 13 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, pre-RT baseline status in the GI, GU, and sexual domains fully recovered between 3 months and 1 year after therapy, remaining stable for at least 5 years. Two previous series have shown stability of HRQOL outcomes at 2 years after postoperative IMRT without image guidance, 34,35 and we provide evidence this is maintained with longer follow-up. The impact of postprostatectomy RT in sexual function represents a major concern influenced by low residual function after surgery.…”

Section: Discussionsupporting

confidence: 68%

“…As shown in Table 4, the literature regarding patientreported outcomes related to treatment toxicities and HRQOL in the postprostatectomy setting is limited. [32][33][34][35] Importantly, this study demonstrates a transient negative impact in HRQOL. However, pre-RT baseline status in the GI, GU, and sexual domains fully recovered between 3 months and 1 year after therapy, remaining stable for at least 5 years.…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Berlin

Cho

Kong

et al. 2015

Practical Radiation Oncology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 87%

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Berlin

Cho

Kong

et al. 2015

Practical Radiation Oncology

View full text Add to dashboard Cite

“…In four other studies [6,12–14], the psychological domain of QOL improved during RT. In contrast, in five studies [15–19], the physical, psychological, and social domains of QOL did not change during patients’ RT. Only two small prospective studies were found that assessed the spiritual domain of QOL in patients undergoing RT [20,21].…”

Section: Introductionmentioning

confidence: 84%

Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers

et al. 2016

View full text Add to dashboard Cite

Purpose Not all oncology patients and their family caregivers (FCs) experience the same quality of life (QOL). The purposes of this study were to identify latent classes of oncology patients (n=168) and their FCs (n=85) with distinct physical, psychological, social, and spiritual well-being trajectories from prior to through four months after the completion of radiation therapy and to evaluate for demographic, clinical, and genetic characteristics that distinguished between these latent classes. Methods Using growth mixture modelling, two latent classes were found for three (i.e., physical, psychological, and social well-being) of the four QOL domains evaluated. Results Across these three domains, the largest percentage of participants reported relatively high well-being scores across the six months of the study. Across these three QOL domains, patients and FCs who were younger, female, belonged to an ethnic minority group, had children at home, had multiple comorbid conditions, or had a lower functional status were more likely to be classified in the lower QOL class. The social well-being domain was the only domain that had a polymorphism in nuclear factor kappa beta 2 (NFKB2) associated with latent class membership. Carrying one or two doses of the rare allele for rs7897947 was associated with a 52% decrease in the odds of belonging to the lower social well-being class (OR (95% CI) = .46 (.21, .99), p=.049). Conclusions These findings suggest that a number of phenotypic and molecular characteristics contribute to differences in QOL in oncology patients and their FCs.

show abstract

“…Although SRT may achieve biochemical responses, there is no Level-1 evidence that shows a survival benefit [2,3]. Therefore, it is important to understand the additional treatment burden associated with SRT and its effect on health-related quality of life (HRQoL) [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Salvage Radiotherapy and its Timing on the Health-related Quality of Life of Prostate Cancer Patients

et al. 2016

View full text Add to dashboard Cite

Health‐related quality of life using intensity‐modulated radiation therapy for post‐prostatectomy radiotherapy

Abstract: This report on HRQoL following post-prostatectomy IMRT demonstrates no variation in mean scores in any domain and only 1.6% of patients reporting a greater than 20-point deterioration between baseline and 15-24 months in bowel function.

Cited by 13 publications

References 33 publications

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers

The Effect of Salvage Radiotherapy and its Timing on the Health-related Quality of Life of Prostate Cancer Patients

Contact Info

Product

Resources

About