Health risk assessment techniques to evaluate non-carcinogenic human health risk due to fluoride, nitrite and nitrate using Monte Carlo simulation and sensitivity analysis in Groundwater of Khaf County, Iran

Bazeli, Javad; Ghalehaskar, Sahar; Morovati, Maryam; Soleimani, Hamed; Masoumi, Safdar; Sani, Abolfazl Rahmani; Saghi, Mohammad Hossein; Rastegar, Ayoob

doi:10.1080/03067319.2020.1743280

Cited by 60 publications

(11 citation statements)

References 55 publications

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“…Nitrite did not pose a non-carcinogenic risk. A sensitivity analysis showed that nitrate, nitrite, and fluoride concentration parameters had the most impact on increasing sensitivity in the four population groups studied (Bazeli et al 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of water quality of Chahnimeh as natural reservoirs from Sistan region in southwestern Iran: a Monte Carlo simulation and Sobol sensitivity assessment

Kamani

Hosseini

Mohebi

et al. 2023

Environ Sci Pollut Res

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Maintaining the water quality is essential because of the limitation of drinking water bodies and their significant effects on life. Recently, much scientific interest has been attracted to the ecological condition assessment of water resources. Because of numerous health issues connected to water quality, the present work aimed to define the water quality status of Chahnimeh reservoirs, Sistan and Baluchistan province, Iran via the Iran Water Quality Index (IRWQISC), the National Sanitation Foundation Water Quality Index (NSFWQI), and human risk assessment. This cross-sectional descriptive work was accomplished in 4 seasons in 2020. The samples were gathered from 5 various points of Chahnimeh reservoirs. This study led to the results that the NSFWQI index was between 29.4 to 49.32, which showed “bad” quality, and the IRWQI index was between 19.27 and 39.23, which indicated “bad” and “relatively bad” quality. The best water quality based on both indexes was observed in the spring, and the worst was in the fall and summer. The highest value of HQ related to nitrate in drinking water was 1.60 in the group of children. However, according to the Monte Carlo simulation, HQ95% was estimated as 1.29. The Sobol sensitivity analysis of the first-order effect showed that daily water’s daily ingestion rate (IR) was the most sensitive input. In addition, the value of the second-order effect indicated that the interaction effect of concentration—ingestion rate was the most sensitive input parameter for HQ. Therefore, regular monitoring is necessary to ensure water safety for human consumption.

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Section: Resultsmentioning

confidence: 99%

Evaluation of water quality of Chahnimeh as natural reservoirs from Sistan region in southwestern Iran: a Monte Carlo simulation and Sobol sensitivity assessment

Kamani

Hosseini

Mohebi

et al. 2023

Environ Sci Pollut Res

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“…In the risk assessment methods uncertainty analysis is necessary to consider the fact that there are some differences between humans and animals (some risk assessment parameters obtain from animal experiments), there are some differences between human which lives in the same community, also certainty analysis can cover the gape of the researches and help to researchers. In this study, as shown in Figure 2 the THI of PTEs in wheat and different flours for bread types by considering appropriate confidence intervals (95%) were evaluated by Oracle Crystal Ball software (version 11.1.2.4.850) with 10000 iterations [ 73 ]. In the assessment of health risk, all actions should be considered the conservative situation, so in the present study, 95th percentile is considered as an action cut point.…”

Section: Resultsmentioning

confidence: 99%

Potential toxic elements (PTEs) concentration in wheat and flour products in Iran: A probabilistic risk assessment

Pirhadi

Alikord

Tajdar-Oranj

et al. 2022

Heliyon

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“…Sensitivity analysis can characterize the factors that influence risk assessment most (Mohammadpour et al 2022a , b ). In this approach, the final output's uncertainty is influenced by input factors’ variability (Bazeli et al 2022 ).…”

Section: Resultsmentioning

confidence: 99%

The concentration of potentially toxic elements (PTEs) in drinking water from Shiraz, Iran: a health risk assessment of samples

Mohammadpour

Emadi

Samaei

et al. 2022

Environ Sci Pollut Res

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The existence of potentially toxic elements (PTEs) in water bodies has posed a menace to human health. Thus, water resources should be protected from PTEs, and their effect on the exposed population should be investigated. In the present investigation, the concentrations of PTEs such as lead (Pb), mercury (Hg), manganese (Mn), and iron(Fe) in the drinking water of Shiraz, Iran, were determined for the first time. In addition, hazard quotient, hazard index, cancer risk, and sensitivity analysis were applied to estimate the noncarcinogenic and carcinogenic impacts of Pb, Hg, Mn, and Fe on exposed children and adults through ingestion. The mean concentrations (µg/L) of Pb, Hg, Mn, and Fe were 0.36, 0.32, 2.28, and 8.72, respectively, in winter and 0.50, 0.20, 0.55, and 10.36, respectively, in summer. The results displayed that Fe concentration was more than the other PTEs. PTE concentrations were lower than the standard values of the Environment Protection Agency and World Health Organization. Values of the degree of contamination and heavy metal pollution index for lead, mercury, manganese, and iron were significantly low (< 1) and excellent (< 50), respectively. Based on the Spearman rank correlation analysis, positive and negative relationships were observed in the present study. The observations of the health risk assessment demonstrated that mercury, lead, iron, and manganese had an acceptable level of noncarcinogenic harmful health risk in exposed children and adults (hazard quotients < 1 and hazard index < 1). The carcinogenic risk of lead was low (< E − 06), which can be neglected. Monte Carlo simulation showed that water intake rate and mercury concentration were the most critical parameters in the hazard index for children and adults. Lead concentration was also the most crucial factor in the cancer risk analysis. The results of the present study proved that the drinking water of Shiraz is safe and healthy and can be confidently consumed by people.

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Health risk assessment techniques to evaluate non-carcinogenic human health risk due to fluoride, nitrite and nitrate using Monte Carlo simulation and sensitivity analysis in Groundwater of Khaf County, Iran

Cited by 60 publications

References 55 publications

Evaluation of water quality of Chahnimeh as natural reservoirs from Sistan region in southwestern Iran: a Monte Carlo simulation and Sobol sensitivity assessment

Evaluation of water quality of Chahnimeh as natural reservoirs from Sistan region in southwestern Iran: a Monte Carlo simulation and Sobol sensitivity assessment

Potential toxic elements (PTEs) concentration in wheat and flour products in Iran: A probabilistic risk assessment

The concentration of potentially toxic elements (PTEs) in drinking water from Shiraz, Iran: a health risk assessment of samples

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