One of the goals of the National Health System is to provide access to health services for vulnerable groups such as street children, as they have a higher probability of experiencing health-related problems. Whereas studies on street children vary, very few studies address social factors associated with the health-seeking behaviour of street children. This study, therefore, examined the social determinants and implications of health-seeking behaviour among street children in Yenagoa Bayelsa State. The Health Belief Model and Andersen Healthcare Utilisation Model were the framework, while a mixed research design was employed. Yenagoa City was purposely selected for the study because it is the state capital, hence it is home to a great number of street children. 384 respondents were selected using Abrahamson and Gahlinger’s sample size determination formula. Accidental sampling technique was used to administer a structured questionnaire to respondents. Five Key Informant Interviews were conducted with staff from the Ministry of Women Affairs and Synergy-Care Development Initiative (SDI). Quantitative data were analysed using descriptive statistics and correlation at p≤0.05, while the qualitative data were content-analysed. The average age of the respondents was 14 years. Findings revealed that headaches, malaria, fever/common colds, cough/chest pain, chicken pox, head worms/lice, and STDs are the main diseases commonly associated with street children. Most street children preferred traditional medicine and self-medication as their treatment pathways. The study concluded that age, area of residence, relationship status, father’s current occupation and level of education all significantly influenced street children's health-seeking behaviours. Tailored intervention programs and financial support were some of the recommendations made.