Health Service Use, Costs, and Adverse Events Associated with Potentially Inappropriate Medication in Old Age in Germany: Retrospective Matched Cohort Study

Abstract

Increased healthcare utilization and costs as well as an increased probability for adverse events in individuals exposed to PIM demonstrate the health economic relevance of PIM prescriptions. Whether avoiding PIM listed on the PRISCUS list may potentially improve the quality and efficiency of healthcare is currently unknown.

The effectiveness of integrative healthcare for chronic disease: A systematic review

“…However, downstream cost savings attributed to reductions in the use of other conventional healthcare resources (such as analgesics) appeared to offset these IHC service delivery costs. This suggests that while an IHC approach may not be cost saving in some instances (at least for the management of back and neck pain), the cost to avert analgesic use (and potential adverse events) could represent good value for money …”

“…This suggests that while an IHC approach may not be cost saving in some instances (at least for the management of back and neck pain), the cost to avert analgesic use (and potential adverse events) could represent good value for money. 45 The types of therapies included in an integrative healthcare model are likely to influence the extent to which the model will be The findings of this review indicate that employing an integrated approach for chronic disease management may be of some benefit, although, the low volume of studies, and the considerable heterogeneity of study populations/conditions and outcome measures prevents any definitive conclusions. Consequently, there is a clear need for further research in this area.…”

Healthcare resource utilization in patients with metastatic melanoma receiving first-line therapy with dabrafenib + trametinib versus nivolumab or pembrolizumab monotherapy

“…mean only, mean and standard deviation) for the covariate distribution will be the same in the weighted cohort (here N/P) as in the reference cohort (here D þ T). Although recently developed, e-balance is increasingly used in observational studies [18][19][20][21] . To ensure that the weighting approach achieved its purpose, balancing of the two cohorts before and after e-balance was assessed using standardized differences.…”

Impact of medication review via tele-expertise on unplanned hospitalizations at 3 months of nursing homes patients (TEM-EHPAD): study protocol for a randomized controlled trial

“…The challenge for the prescriber when treating older multimorbid patients is to strike a balance between optimizing chronic disease control and minimizing the risks of polypharmacy. In the elderly population, potentially inappropriate medication use, drug-drug interaction or drug-disease interaction are associated with negative health outcomes and contribute significantly to 6-17% of hospital admissions in older adults [2][3][4][5]. In France, medication-induced iatrogenic disease is believed to account for over 10% of hospital admissions in patients over 65 years of age, 20% of admissions in patients over 75 years of age and 25% of admissions in those over the age of 85 [6].…”