Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China

Wang, Yongxiang; Han, Xiaolei; Zhang, Xian-Da; Zhang, Zhonglin; Liu, Cong; Tang, Shi; Hou, Tingting; Liu, Cuicui; Han, Xiaobin; Zhang, Qinghua; Feng, Jianli; Yin, Ling; Song, Lin; Dong, Yi; Li, Rui; Li, Yuanjing; Ngandu, Tiia; Kivipelto, Miia; Snyder, Heather M.; Carrillo, María C.; Persson, Jonas; Fratiglioni, Laura; Launer, Lenore J.; Jia, Jianping; Du, Yifeng; Qiu, Chengxuan

doi:10.1002/trc2.12254

Cited by 47 publications

(89 citation statements)

References 44 publications

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“…The study sample was derived from participants in the baseline examinations of the cluster‐randomized controlled Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND‐China), as previously reported [14]. In brief, MIND‐China, as part of the World‐Wide FINGERS Network [15], targeted people who were aged ≥60 years and living in rural communities (52 villages) of Yanlou Town, Yanggu County, Western Shandong Province.…”

Section: Methodsmentioning

confidence: 99%

Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural‐dwelling older adults in China: A population‐based study

Wang

Liu

et al. 2022

Euro J of Neurology

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Background and purpose Little is known about whether nonalcoholic fatty liver disease (NAFLD) is associated with dementia or the role of serum proinflammatory cytokines in the association. We aimed to investigate the interrelationships of NAFLD, serum cytokines, and dementia among rural‐dwelling older adults. Methods This population‐based cross‐sectional study included 5129 participants (aged ≥60 years; 61.79% women) who were living in rural communities and examined in March 2018–September 2018. NAFLD was defined through transabdominal ultrasound examination in the absence of hepatitis B or excessive alcohol consumption. Serum cytokines were measured in a subsample (n = 1686). Dementia, Alzheimer disease (AD), and vascular dementia (VaD) were diagnosed following international criteria. Data were analyzed with logistic regression and mediation models. Results Of the 5129 participants, 455 (8.87%) were detected with moderate‐to‐severe NAFLD, and 292 (5.69%) were diagnosed with dementia (188 with AD and 96 with VaD). The multivariable adjusted odds ratios associated with moderate‐to‐severe (vs. no‐to‐mild) NAFLD were 2.22 (95% confidence interval [CI] = 1.41–3.49) for all‐cause dementia, 1.88 (95% CI = 1.01–3.50) for AD, and 2.62 (95% CI = 1.33–5.17) for VaD. In the cytokine subsample, controlling for multiple potential confounders, moderate‐to‐severe NAFLD was significantly associated with higher levels of serum monocyte chemotactic protein‐1, interleukin‐17A, interleukin‐6 (IL‐6), interleukin‐8, and tumor necrosis factor‐α (P < 0.05). The mediation analysis showed that IL‐6 mediated 12.56% of the association between NAFLD and VaD. Conclusions Moderate‐to‐severe nonalcoholic fatty liver disease is associated with dementia and AD, especially with VaD, among rural‐dwelling Chinese older adults, in which the association with VaD is partly mediated by serum inflammatory cytokines.

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Section: Methodsmentioning

confidence: 99%

Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural‐dwelling older adults in China: A population‐based study

Wang

Liu

et al. 2022

Euro J of Neurology

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“…This community-based cross-sectional study used data from the baseline survey of the ongoing Multimodal Interventions to delay Dementia and disability in rural China (MIND-China), which is part of the World-Wide FINGERS Network. 19 , 20 Baseline assessments of MIND-China targeted people who were aged ≥65 years by the end of 2017 and living in the 52 villages of Yanlou Town, Yanggu County, western Shandong Province, as previously reported. 19 , 21 Briefly, in March–September 2018, 5246 participants (80.3% of all eligible people) were examined as the baseline survey for MIND-China.…”

Section: Methodsmentioning

confidence: 95%

Association of Cardiovascular Health Metrics with Dementia in Rural Chinese Older Adults: A Population-Based Study

Han¹,

Wang²,

Jiang³

et al. 2022

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Purpose We explore the associations of individual and composite cardiovascular health metrics with all-cause dementia, Alzheimer’s disease, and vascular dementia among rural-dwelling older adults and the potential age variations in their associations. Patients and Methods This community-based cross-sectional study included 4980 older adults (age ≥65 years; 57.23% women) from the baseline examination of MIND-China. In March–September 2018, data were collected via face-to-face interviews, clinical examinations, and laboratory test. We defined six cardiovascular health metrics according to the modified American Heart Association’s recommendations. We diagnosed dementia and its subtypes following the international criteria. Data were analyzed using logistic regression models. Results Of all the participants, 250 were diagnosed with dementia, including 165 with Alzheimer’s disease and 75 with vascular dementia. Ideal composite global cardiovascular health metrics (vs poor composite metrics) were associated with a multi-adjusted odds ratio (95% confidence interval) of 0.62 (0.42–0.93) for dementia, 0.88 (0.52–1.48) for Alzheimer’s disease, and 0.31 (0.16–0.60) for vascular dementia. Moreover, ideal biological cardiovascular health metrics were associated with multi-adjusted odds ratio of 0.52 (0.28–0.95) for dementia and 0.21 (0.06–0.77) for vascular dementia in young–old adults (65–74 years), whereas ideal behavioral cardiovascular health metrics were associated with multi-adjusted odds ratio of 0.48 (0.26–0.89) for dementia and 0.16 (0.06–0.43) for vascular dementia in old–old adults (≥75 years). Conclusion Our results suggest that ideal cardiovascular health metrics are cross-sectionally associated with a low likelihood of dementia and vascular dementia among rural-dwelling older Chinese adults. The associations vary with age, components of cardiovascular health metrics, and dementia subtypes.

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“…The automated biochemical analyzer and instruments (eg, electronic blood pressure monitor, 12-lead resting ECG, ultrasonic machine, and automated blood cell analyzer) are regularly calibrated and standardized following the manufacturer’s instructions. 13 …”

Section: Methodsmentioning

confidence: 99%

Self-Reported Sleep Characteristics Associated with Cardiovascular Disease Among Older Adults Living in Rural Eastern China: A Population-Based Study

Qin¹,

Liu²,

Wang³

et al. 2022

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Purpose To investigate the cross-sectional associations of self-reported sleep characteristics with cardiovascular diseases (CVDs) and cardiovascular multimorbidity in older adults living in rural Eastern China. Patients and Methods This population-based study included 4618 participants (age ≥65 years; 56.5% women) living in rural Eastern China. In March–September 2018, data were collected through interviews, clinical examinations, neuropsychological testing, and laboratory tests. Sleep parameters were assessed using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Score, and Berlin questionnaire. Coronary heart disease (CHD), heart failure (HF), and stroke were defined according to in-person interviews, clinical and neurological examinations, and electrocardiogram examination. Data were analyzed using logistic regression and restricted cubic spline regression. Results CHD was diagnosed in 991 participants, HF in 135 participants, and stroke in 696 participants. The multivariable-adjusted odds ratio (OR) of CHD was 1.27 (95% CI, 1.09–1.49) for sleep duration ≤6 hours/night (vs >6–8 hours/night), 1.40 (1.20–1.62) for poor sleep quality, and 1.22 (1.04–1.43) for high risk for obstructive sleep apnea (OSA). The OR of HF was 2.16 (1.38–3.39) for sleep duration >8 hours/night, and 1.76 (1.22–2.54) for high risk for OSA. In addition, the OR of stroke was 1.23 (1.04–1.46) for poor sleep quality, 1.32 (1.01–1.72) for excessive daytime sleepiness, and 1.42 (1.19–1.70) for high risk for OSA. The associations of poor sleep with cardiovascular multimorbidity (≥2 CVDs) were stronger than that of sleep problems with a single CVD. Conclusion Extreme sleep duration, high risk for OSA, and other sleep problems were associated with CVDs, especially cardiovascular multimorbidity.

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Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China

Cited by 47 publications

References 44 publications

Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural‐dwelling older adults in China: A population‐based study

Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural‐dwelling older adults in China: A population‐based study

Association of Cardiovascular Health Metrics with Dementia in Rural Chinese Older Adults: A Population-Based Study

Self-Reported Sleep Characteristics Associated with Cardiovascular Disease Among Older Adults Living in Rural Eastern China: A Population-Based Study

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