Background: China is facing big pressure due to its high aging rate. Compared to other age groups, the elderly are characterized by a high number of multiple chronic diseases and need to frequently visit hospitals. However, most seniors are unable to independently complete medical treatments in smart hospitals with complex self-help integrated machines, scattered departments, popular appointment registration, and convenient mobile payment, and need to be accompanied by their adult children. Medical escorts might replace the offspring’s role, but their willingness to utilize elderly medical escort service (EMES) is associated with different factors.Methods: This sequential mixed-methods research was performed in communities across three cities in Jiangsu Province, China. It included a cross-sectional survey with a convenient sample size of 1936 participants having medical experiences with the elderly, and face-to-face interviews with 21 individuals. The quantitative survey was used to determine the participants’ expectations and acceptability of EMES. The semi-structured interview was performed to explore the barriers and facilitators of utilizing EMES.Results: Among 1936 individuals that responded to the questionnaire, 68.2% were willing to use the EMES. The willingness to utilize EMES was associated with long-distance separation from seniors [OR=0.79, 95% CI (0.63-0.98), p=0.033], difficulties in taking leaves to accompany the elderly to medical appointments [OR=1.39, 95% CI (1.11-1.73), p=0.003], outpatient satisfaction [OR=1.24, 95% CI (1.13-1.36), p<0.001], payment for EMES [OR=2.56, 95% CI (2.07-3.18), p<0.001], escorts being trained [OR=2.35, 95% CI (1.80-3.07), p<0.001] and licensed [OR=1.31, 95%CI (1.01-1.72), p=0.044], and EMES being graded [OR=1.93, 95% CI (1.48-2.51), p<0.001]. Both data suggested that regarding training, participants paid more attention to professional ethics. Additionally, the traditional Chinese culture of filial piety can not be ignored while using EMES.Conclusions: This survey indicated that the demands of the children’s willingness to utilize EMES are high and urgent. The results might guide EMES providers to improve their professional skills especially ethics and combine the need for children to do their filial duty that would be welcomed by users.