Health status in COPD cannot be measured by the St George's Respiratory Questionnaire alone: an evaluation of the underlying concepts of this questionnaire

Daudey, Leonie; Peters, Jeannette B.; Molema, Johan; Dekhuijzen, PN Richard; Prins, Judith B.; Heijdra, Yvonne F.; Vercoulen, Jan H.

doi:10.1186/1465-9921-11-98

Cited by 37 publications

(25 citation statements)

References 32 publications

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“…The CCQ was chosen for this study because it has proven reliability, validity, responsiveness, and high reproducibility 25. In addition, the CCQ is very concise and easily understood by patients,27 while providing information on symptoms and damage that better reflected their HRQoL 28. Permission was obtained prior to this study.…”

Section: Methodsmentioning

confidence: 99%

Does the duration of smoking cessation have an impact on hospital admission and health-related quality of life amongst COPD patients?

Hassan¹,

Aziz²,

Hassan³

et al. 2014

COPD

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BackgroundLack of awareness among ex-smokers on the benefits of sustaining smoking cessation may be the main cause of their smoking relapse. This study explored health-related quality of life (HRQoL) and hospital admission amongst chronic obstructive pulmonary disease (COPD) patients according to the duration of smoking cessation.Materials and methodsThis study recruited COPD patients from a chest clinic who agreed to participate in a medication therapy-adherence program from January to June 2013. They were interviewed during their visits to obtain information regarding their smoking history and HRQoL. They were divided into three groups according to smoking status (sustained quitters, quit ≥5 years; quitters, quit <5 years; and smokers, smoking at least one cigarette/day). The effects of the duration of cessation on HRQoL and hospital admission were analyzed using a multinomial logistic model.ResultsA total of 117 participants with moderate COPD met the inclusion criteria, who were comprised of 41 sustained quitters, 40 quitters, and 36 smokers. Several features were similar across the groups. Most of them were married elderly men (aged >64 years) with low-to-middle level of education, who smoked more than 33 cigarettes per day and had high levels of adherence to the medication regimen. The results showed that sustained quitters were less likely to have respiratory symptoms (cough, phlegm and dyspnea) than smokers (odds ratio 0.02, confidence interval 0–0.12; P<0.001). The hospital admission rate per year was increased in quitters compared to smokers (odds ratio 4.5, confidence interval 1.91–10.59; P<0.005).ConclusionA longer duration of quitting smoking will increase the benefits to COPD patients, even if they experience increased episodic respiratory symptoms in the early period of the cessation. Thus, the findings of this study show the benefits of early smoking cessation.

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Section: Methodsmentioning

confidence: 99%

Does the duration of smoking cessation have an impact on hospital admission and health-related quality of life amongst COPD patients?

Hassan¹,

Aziz²,

Hassan³

et al. 2014

COPD

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“…Previous studies reported that IL-10 production in response to lipopolysaccharide was impaired in monocyte/macrophage lineage of asthmatics compared with normal subjects [29, 30]. On the contrary, other studies reported an increase in IL-10-producing T cells and macrophages in asthmatic airways compared with normal subjects, and that those cells were further increased after allergen challenge [20,31,32,33].…”

Section: Discussionmentioning

confidence: 82%

Different Profiles of IL-10+IFN-γ–IL-4–CD4+ T Cells in the Peripheral Blood in Atopic and Non-Atopic Asthmatics

et al. 2007

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Background: The impaired production of interleukin (IL) 10 from regulatory T cells has been proposed as a causal mechanism of asthma. Although IL-10-producing (IL-10+) T cells are detectable in the peripheral blood, their significance in the pathophysiology of asthma remains uncertain. Objectives: This study aimed to investigate the profile of circulating IL-10+CD4+ T cells in atopic and non-atopic asthma. Methods: Atopic and non-atopic asthmatics were divided into a mild and severe group. Their peripheral blood mononuclear cells (PBMCs) were stimulated with anti-CD3 and anti-CD28 antibodies and then processed for triple cytokine flow cytometry directed to IL-10, interferon (IFN) γ and IL-4. Results: IL-10+CD4+ cells were exclusively detected in the IFN-γ–IL-4– population. In atopic asthma, the frequency of IL-10+IFN-γ–IL-4–CD4+ cells in the severe group was significantly lower than that in the mild group. The frequency of IL-10+IFN-γ–IL-4–CD4+ cells in the severe group was not significantly different from that in the mild group of those with non-atopic asthma. The frequency of IL-4+IFN-γ–IL-10–CD4+ cells (Th2) was significantly higher in the group with mild atopic asthma than in that with mild non-atopic asthma. IFN-γ+IL-4–IL-10–CD4+ cells (Th1) did not differ between groups, irrespective whether the subjects suffered from atopic or non-atopic asthma. Conclusions: IL-10+CD4+ cells in PBMCs may be distinct from Th1 or Th2 and likely have the profile of regulatory T cells. The differential association of IL-10+IFN-γ–IL-4–CD4+ cells with clinical severity between atopic and non-atopic asthma implies that its pathophysiological significance may differ among asthma phenotypes.

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“…Lung Disease (GOLD (24)(25)(26). Embora não necessariamente causalmente associada com a doença, à existência de DPOC podem realmente aumentar o risco de outra doença.…”

Section: Global Initiative For Chronic Obstructiveunclassified

Perfil Demográfico E Clínico De Portadores De Doença Pulmonar Obstrutiva Crónica No Sul Do Brasil

et al. 2017

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RESUMOObjetivo: Caracterizar uma população de pacientes portadores de Doença Pulmonar Obstrutiva Crônica (DPOC) acompanhados em um Programa de Reabilitação Pulmonar (PRP). Método: O estudo foi observacional descritivo, com 83 pacientes com diagnóstico de DPOC. Todos os pacientes realizaram espirometria e exames laboratoriais bioquímicos. Resultados: Foram incluídos 47 homens (56,6%) e 36 mulheres (43,4%). A comorbidades Hipertensão Arterial (HAS) foi mais relevante em 21 (44,6%) dos homens e 14 (38,8%) das mulheres, seguido de cardiopatias 8 homens (17 %) e 2 mulheres (5,5 %) e Diabetes Mellitus (DM), sendo esta uma comorbidade encontrada quase que exclusivamente em homens, 7 (14,8%) e apenas 1 mulher (2,7%). Conclusão: O acampamento dos parâmetros clínicos e laboratoriais de forma sistemática pode auxiliar na promoção e prevenção das comorbidades associadas a doenças.Palavras chave: Doença pulmonar obstrutiva crônica, epidemiologia, centro de reabilitação pulmonar. ABSTRACTObjective: To characterize a population of Chronic Obstructive Pulmonary Disease (COPD) patients followed through a Pulmonary Rehabilitation Program (PRP). Methods: the study was observational, descriptive, with 83 patients with a diagnosis of COPD. All patients underwent spirometry and biochemical laboratory tests. Results: 47 men (56.6%) and 36 women (43.4%) were included. The most relevant comorbidity was Hyperten-* Fisioterapeuta, Doutora em Ciências Pneumológicas. Professora do curso de fisioterapia da Universidade Feevale. Novo Hamburgo, Brasil.

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Health status in COPD cannot be measured by the St George's Respiratory Questionnaire alone: an evaluation of the underlying concepts of this questionnaire

Cited by 37 publications

References 32 publications

Does the duration of smoking cessation have an impact on hospital admission and health-related quality of life amongst COPD patients?

Does the duration of smoking cessation have an impact on hospital admission and health-related quality of life amongst COPD patients?

Different Profiles of IL-10+IFN-γ–IL-4–CD4+ T Cells in the Peripheral Blood in Atopic and Non-Atopic Asthmatics

Perfil Demográfico E Clínico De Portadores De Doença Pulmonar Obstrutiva Crónica No Sul Do Brasil

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