Health Status of Elderly People Living Near E-Waste Recycling Sites: Association of E-Waste Dismantling Activities with Legacy Perfluoroalkyl Substances (PFASs)

Zhang, Tao; Zhang, Bo; Bai, Xueyuan; Yao, Yiming; Wang, Lei; Shu, Yingying; Huang, Xiongfei; Sun, Hongwen

doi:10.1021/acs.estlett.9b00085

Cited by 43 publications

(15 citation statements)

References 52 publications

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“…Perfluoroalkyl substances (PFASs) are a major class of organic pollutants of increasing global concern that have become widespread as a result of their extensive use in common products and industrial applications, including firefighting foams and coatings, surfactants, lubricants, and as additives and byproducts of polymer production. , The total global amount of PFASs that have been produced to date is hundreds of thousands of tons. , PFASs are resistant to degradation, readily bioaccumulate, and thus persist in the environment. PFASs, including perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), can be detected globally in air, water, soil, house dust, and many different marine and terrestrial organisms, including humans .…”

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confidence: 99%

“…1,2 The total global amount of PFASs that have been produced to date is hundreds of thousands of tons. 3,4 PFASs are resistant to degradation, readily bioaccumulate, and thus persist in the environment. PFASs, including perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), can be detected globally in air, water, soil, house dust, and many different marine and terrestrial organisms, including humans.…”

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confidence: 99%

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Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

et al. 2020

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Perfluoroalkyl substances (PFASs) persist and are ubiquitous in the environment. The origins of PFAS toxicity and how they specifically affect the functions of proteins remain unclear. Herein, we report that PFASs can strongly inhibit the activity of human carbonic anhydrases (hCAs), which are ubiquitous enzymes that catalyze the hydration of CO2, are abundant in the blood and organs of mammals, and involved in pH regulation, ion homeostasis, and biosynthesis. The interactions between PFASs and hCAs were investigated using stopped-flow kinetic enzyme-inhibition measurements, native mass spectrometry (MS), and ligand-docking simulations. Narrow-bore emitters in native MS with inner diameters of ∼300 nm were used to directly and simultaneously measure the dissociation constants of 11 PFASs to an enzyme, which was not possible using conventional emitters. The data from native MS and stopped-flow measurements were in excellent agreement. Of 15 PFASs investigated, eight can inhibit at least one of four hCA isozymes (I, II, IX, and XII) with submicromolar inhibition constants, including perfluorooctanoic acid, perfluorooctanesulfonamide, and perfluorooctanesulfonic acid. Some PFASs, including those with both short and long perfluoromethylene chains, can effectively inhibit at least one hCA isozyme with low nanomolar inhibition constants.

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confidence: 99%

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Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

et al. 2020

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“…Poly- and perfluoroalkyl substances (PFASs), such as perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), have been widely detected in the environment and human bodies. − Because of their extreme persistence and toxicity, − PFOS and PFOA have been strictly regulated over the past several decades − and have been replaced with short-chain PFASs in a number of industrial and commercial products. , In recent years, the ammonium salt of hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX and used as a main substitute chemical for PFOA, has been under public scrutiny and has been the subject of several major lawsuits related to drinking water contamination. − …”

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confidence: 99%

High-Efficiency Capture and Recovery of Anionic Perfluoroalkyl Substances from Water Using PVA/PDDA Nanofibrous Membranes with Near-Zero Energy Consumption

Guo

Zhang

Peng

et al. 2021

Environ. Sci. Technol. Lett.

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Poly- and perfluoroalkyl substances (PFASs) have caused severe public concerns due to their toxicity and extensive occurrence in the aquatic environment. This study reports a highly porous amine-functionalized membrane for the rapid capture of GenX and other anionic PFASs [e.g., perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA)] from contaminated water with near-zero energy consumption. The optimized membrane, prepared by electrospinning of polydiallyldimethylammonium chloride using cross-linked poly(vinyl alcohol) as a binder, had a high water permeability of ∼2700 L m–2 h–1 kPa–1. This high permeability enabled rapid gravity-driven filtration of contaminated water with a merely 5 cm water head, corresponding to an estimated energy consumption of as little as 2.7 × 10–4 kWh/m3. Meanwhile, the membrane showed highly efficient capture of GenX (>97%), PFOS (>99%), and PFOA (>99%). A large capture capacity of 1.2 × 106 μg/m2 was demonstrated for GenX. The captured GenX was recovered and concentrated with a small-volume NaCl/methanol solution, which simultaneously regenerated the membrane for its reuse. Over a 12-cycle capture–recovery test, the membrane demonstrated a high GenX recovery ratio of 94% and a volumetric concentration factor of 40. Our study provides a promising strategy for effective capture and recovery of GenX to enable its sustainable control and remediation.

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“…As the number of cycles increases, the amount of TOC and COD reduced gradually, and after the fifth cycle, they are 0.13 and 15.08 mg/L, respectively. In this case, the discarded PSCs may cause an increase in oxygen consumption and may release CO 2 into the environment …”

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confidence: 99%

“…In this case, the discarded PSCs may cause an increase in oxygen consumption and may release CO 2 into the environment. 19 Overall, almost all the chemicals used in the fabrication of PSCs can readily leach out when subjected to water, rain, and landfill leachate. Results confirmed that Pb, the most concerning heavy metal in PSCs, can easily leach out even in DI water extraction.…”

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confidence: 99%

Pb-Based Perovskite Solar Cells and the Underlying Pollution behind Clean Energy: Dynamic Leaching of Toxic Substances from Discarded Perovskite Solar Cells

Liu

Zhang

et al. 2020

J. Phys. Chem. Lett.

117

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Toxicants like Pb in lead-based perovskite solar cells (PSCs) may become available to humans through leaching and transport through water, air, and soil. Here, we summarize the potential toxicity of different substances in PSCs and determine the leaching concentration of typical heavy metals used in PSCs through dynamic leaching tests (DLTs). Extraction fluids for the standard toxicity characteristic leaching procedure, synthetic precipitation leaching procedure, and deionized water were used as the DLT leaching solutions. Results indicated that the leaching concentration of Pb exceeded the hazardous waste limit of 5 mg/L. In addition, Pb was found to continuously leach out in the leaching cycles of water extraction. The findings confirmed that discarded PSCs may release Pb when subjected to water, rain, and landfill leachate. Total organic carbon and chemical oxygen demand analyses indicated that discarded PSCs could increase the oxygen consumption and may release CO 2 into the environment.

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Health Status of Elderly People Living Near E-Waste Recycling Sites: Association of E-Waste Dismantling Activities with Legacy Perfluoroalkyl Substances (PFASs)

Cited by 43 publications

References 52 publications

Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

High-Efficiency Capture and Recovery of Anionic Perfluoroalkyl Substances from Water Using PVA/PDDA Nanofibrous Membranes with Near-Zero Energy Consumption

Pb-Based Perovskite Solar Cells and the Underlying Pollution behind Clean Energy: Dynamic Leaching of Toxic Substances from Discarded Perovskite Solar Cells

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