Health symptoms and inflammatory blood biomarkers from exposure of recyclable waste workers to particulate matter and bioaerosols

Wikuats, Caroline Fernanda Hei; Silva, Iara da; Prates, Kátia Valéria Marques Cardoso; Silva, Janaina Casado Rodrigues da; Duarte, Eduardo Henrique; Silva, Dulcilena de Matos Castro e; Ribeiro, Marcelo Leite; Simão, Andréa Name Colado; Martins, Leila Droprinchinski

doi:10.1016/j.apr.2022.101323

Cited by 12 publications

(13 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, in a meta-analysis, the diagnosis of upper respiratory disorders appeared to increase as the exposure of the subjects to waste combustion pits increased [15]. Other authors found that short-term air pollution from traffic or organic carbon led to an increase in respiratory infection symptoms and emergency room visits by children [24,25]. It is known that particles contained in air pollutants or incinerator discharges are harmful to health because they can obstruct and inflame the nasal and bronchial passages [26][27][28][29].…”

Section: Discussionmentioning

confidence: 89%

Hematological, cholesterolemic and clinical profile in exposed to outdoor air pollution linked to the incineration of biomedical waste in Benin

DAVOU¹,

Zohoun²,

GBEGNIDE³

et al. 2022

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

Introduction: Incineration is one of the treatment methods for biomedical waste (BMW). It is a source of toxic air pollutant emission. The study aimed to compare the haematological, cholesterolemic and clinical profile of subjects exposed to this pollution to controls. Methods: This was a comparative cross-sectional study on 154 exposed subjects selected within 500 meters of the incineration sites of solid biomedical waste and controls, among new blood donors, matched on age, sex, level of education, cooking mode. The hematological parameters and cholesterolemia were obtained by standardized procedure on automata. The proportions of subjects were compared with a chi-square test. The dispersion analysis of the biological parameters was made by the non-parametric Wilcoxon test at the 5% threshold. Results: The two groups were comparable for matching. The frequency of respiratory symptoms ranged from 20.1 - 79.2% in exposed versus 4.5 - 54.5% in controls. The frequency of neurological symptoms ranged from 26.6 - 76.6% in exposed versus 1.9 - 51.9% in controls. Hemoglobin (p=0.001), hematocrit (p=0.051) were low in the exposed and white blood cells (p=0.003) and platelets (p<0.001) high. Total cholesterol (p<0.001) was twice as high and HDL six times lower in the exposed (p<0.001). Conclusion: The exposed presented a more altered hematological and cholesterolemic profile with more frequent symptoms. It is essential to improve the management practice of BMW in our hospitals through the use of innovative, less polluting technologies

show abstract

Section: Discussionmentioning

confidence: 89%

Hematological, cholesterolemic and clinical profile in exposed to outdoor air pollution linked to the incineration of biomedical waste in Benin

DAVOU¹,

Zohoun²,

GBEGNIDE³

et al. 2022

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

show abstract

“…These levels are comparable to exposure ranges previously reported in the waste sector (0-2×10 6 spores m −3 ) in Norway (2) in Canada, (0.038-1.03×10 6 spores m −3 ) (58) and in Poland (0.143-1.65×10 6 spores m −3 ) (17). On the other hand, much lower exposure levels have been measured in samples from Danish waste transporters (about 33 times the median level) (30) and in Brazilian waste sorting plants (3.2×10 4 spores m −3 ) (5). Higher personal exposure ranges of 0.02-110×10 6 ; 93-1140×10 6 and 0.39-5.01×10 6 spores m −3 have been measured in waste treatment plants in Germany (59), in Denmark (13) and in Norway (27), respectively.…”

Section: Discussionmentioning

confidence: 99%

“…These were instead loaded onto trucks, after inspection, and transported to other sites for incineration. The following work tasks, which are probably most exposed, were selected for the measurements: (1) waste reception and inspection, (2) material sorting line, (3) material shredding and pressing, (4) machine operator/driving and (5) storage. All employees in reception and control, sorting, shredding, and pressing as well as machine operators took part in the sampling campaign.…”

Section: Methodsmentioning

confidence: 99%

“…Relatively high exposure levels of fungi have been measured in waste management (5,17,27,(30)(31)(32). Exposure characterization focusing on how fungal spores and species diversity together with other common bioaerosol components activate TLR2 and TLR4 may provide new insights into important biological effects associated with waste treatment exposure.…”

Section: Introductionmentioning

confidence: 99%

“…A variety of operations in waste processing can generate significant levels of complex microbial-rich dust with relatively high fractions of fungal particles. Although fungal exposure has been described for such occupational settings as a potent inflammatory stimulus, the relationships with inflammatory markers in workers are often inconsistent (1– 5) except for specific cases with Aspergillus sp . (6).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

“Divergent TLR2 and TLR4 activation by fungal spores and species diversity in dust from waste-sorting plants”

Afanou

Mundra²,

Estensmo

et al. 2022

Preprint

View full text Add to dashboard Cite

This manuscript presents the results of an exploratory study on the relationships between NFkB (Nuclear Factor Kappa Chain Enhancer of B-cells) response through TLRs activation by dust characterized by fungal spore concentrations and species diversity. Personal total dust samples were collected from Norwegian waste sorting plants and then characterized for fungal spores and fungal species diversity, as well as for other bioaerosol components, including endotoxins and actinobacteria. The ability of the dust to induce an NFkB response by activating Toll-like receptors 2 (TLR2) and 4 (TLR4) in vitro was evaluated as well as the relationship between such responses and quantifiable bioaerosol components. The average concentrations of bioaerosols were 7.23 mg total dust m-3, 4.49×105fungal spores m-3, 814 endotoxin units m-3, and 0.6×105actinobacteria m-3. The mean diversity measurements were 326; 0.59 and 3.39 for fungal richness, evenness, and Shannon Index, respectively. Overall, fungal OTUs belonging to the Ascomycotina phylum were most abundant (55%), followed by Basidiomycota (33%) and Mucormycota (3%). All samples induced significant NFkB responses through TLR2 and TLR4 activation. While fungal spore levels were positively associated with TLR2 and TLR4 activation, there was a trend that fungal species richness was negatively associated with the activation of these receptors. This observation supports the existence of divergent immunological responses relationship between fungal spore levels and fungal species diversity. Such relationships seem to be described for the first time for dust from waste facilities.

show abstract

Bioaerosol-induced in vitro activation of toll-like receptors and inflammatory biomarker expression in waste workers

Eriksen

Afanou

Straumfors

et al. 2023

Int Arch Occup Environ Health

View full text Add to dashboard Cite

Purpose Occupational exposure to bioaerosols during waste handling remains a health concern for exposed workers. However, exposure-related health effects and underlying immunological mechanisms are still poorly described. Methods The present study assessed the inflammatory potential of work-air samples (n = 56) in vitro and investigated biomarker expression in exposed workers (n = 69) compared to unexposed controls (n = 25). These quantitative results were compared to self-reported health conditions. Results Personal air samples provoked an activation of TLR2 and TLR4 HEK reporter cells in one-third of all samples, indicating that the work environment contained ligands capable of inducing an immune response in vitro. Monocyte levels, as well as plasma biomarker levels, such as IL-1Ra, IL-18 and TNFα were significantly higher in exposed workers, compared to the control group when confounding factors such as BMI, sex, age and smoking habits were accounted for. Furthermore, a significant exposure-related increase in midweek IL-8 levels was measured among exposed workers. Tendencies of increased prevalence of health effects of the respiratory tract were identified in exposed workers. Conclusion Inhalable dust provoked TLR activation in vitro, indicating that an exposure-related immune response may be expected in susceptible workers. However, despite significant differences in inflammatory plasma biomarker levels between exposed and unexposed workers, prevalence of self-reported health effects did not differ between the groups. This may be due to the healthy worker effect, or other factors such as adequate use of personal protective respiratory devices or adaptation to the work environment with reduced activation of the immune system.

show abstract

Health symptoms and inflammatory blood biomarkers from exposure of recyclable waste workers to particulate matter and bioaerosols

Cited by 12 publications

References 114 publications

Hematological, cholesterolemic and clinical profile in exposed to outdoor air pollution linked to the incineration of biomedical waste in Benin

Hematological, cholesterolemic and clinical profile in exposed to outdoor air pollution linked to the incineration of biomedical waste in Benin

“Divergent TLR2 and TLR4 activation by fungal spores and species diversity in dust from waste-sorting plants”

Bioaerosol-induced in vitro activation of toll-like receptors and inflammatory biomarker expression in waste workers

Contact Info

Product

Resources

About