Breast cancer is the most common type of cancer in the world and also in Arab countries. Despite the fact that its incidence and mortality rates in the Arab world are on the rise, preventive care is not practiced by Arab women. Breast cancer screening is highly recommended to detect the disease early, promote health, and reduce mortality rates. Several barriers were found to influence views, beliefs, attitudes, and behaviors of Arab women toward breast cancer screening. Addressing barriers related to the Arab culture, religion, and spirituality, in addition to social and personal barriers, is a critical element that must be wellunderstood to reinforce the importance of breast cancer screening and improve related practices. This chapter discusses the incidence and current status of breast cancer screening in the Arab world. It also examines and analyzes sociocultural, religious, and spiritual barriers to breast cancer screening that must be integrated into